Abstract:
:Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary time, TE insertions can supply new promoter, enhancer, and insulator elements to protein-coding genes and establish novel, species-specific gene regulatory networks. Conversely, ongoing TE-driven insertional mutagenesis, nonhomologous recombination, and other potentially deleterious processes can cause sporadic disease by disrupting genome integrity or inducing abrupt gene expression changes. Here, we discuss recent evidence suggesting that TEs may contribute regulatory innovation to mammalian embryonic and pluripotent states as a means to ward off complete repression by their host genome.
journal_name
Genome Bioljournal_title
Genome biologyauthors
Gerdes P,Richardson SR,Mager DL,Faulkner GJdoi
10.1186/s13059-016-0965-5subject
Has Abstractpub_date
2016-05-09 00:00:00pages
100eissn
1474-7596issn
1474-760Xpii
10.1186/s13059-016-0965-5journal_volume
17pub_type
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