Abstract:
BACKGROUND:There is a large amount of inconsistency in gene structure annotations of bacterial strains. This inconsistency is a frustrating impedance to effective comparative genomic analysis of bacterial strains in promising applications such as gaining insights into bacterial drug resistance. RESULTS:Here, we propose CAMBer as an approach to support comparative analysis of multiple bacterial strains. CAMBer produces what we called multigene families. Each multigene family reveals genes that are in one-to-one correspondence in the bacterial strains, thereby permitting their annotations to be integrated. We present results of our method applied to three human pathogens: Escherichia coli, Mycobacterium tuberculosis and Staphylococcus aureus. CONCLUSIONS:As a result, more accurate and more comprehensive annotations of the bacterial strains can be produced.
journal_name
BMC Genomicsjournal_title
BMC genomicsauthors
Wozniak M,Wong L,Tiuryn Jdoi
10.1186/1471-2164-12-S2-S6subject
Has Abstractpub_date
2011-01-01 00:00:00pages
S6issn
1471-2164pii
1471-2164-12-S2-S6journal_volume
12 Suppl 2pub_type
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