Hepatocyte RXRalpha deficiency in matured and aged mice: impact on the expression of cancer-related hepatic genes in a gender-specific manner.

abstract：BACKGROUND:Sugarcane is a major sugar and biofuel crop, but genomic research and molecular breeding have lagged behind other major crops due to the complexity of auto-allopolyploid genomes. Sugarcane cultivars are frequently aneuploid with chromosome number ranging from 100 to 130, consisting of 70-80 % S. officinarum,...

journal_title：BMC genomics

authors： Zhang J,Sharma A,Yu Q,Wang J,Li L,Zhu L,Zhang X,Chen Y,Ming R

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:The study and analysis of gene expression measurements is the primary focus of functional genomics. Once expression data is available, biologists are faced with the task of extracting (new) knowledge associated to the underlying biological phenomenon. Most often, in order to perform this task, biologists exe...

journal_title：BMC genomics

authors： Miyazaki FA,Guardia GD,Vêncio RZ,de Farias CR

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:Codon usage analysis has been a classical topic for decades and has significances for studies of evolution, mRNA translation, and new gene discovery, etc. While the codon usage varies among different members of the plant kingdom, indicating the necessity for species-specific study, this work has mostly been ...

journal_title：BMC genomics

authors： Feng C,Xu CJ,Wang Y,Liu WL,Yin XR,Li X,Chen M,Chen KS

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are short, non-coding RNAs that regulate gene expression mainly through translational repression of target mRNA molecules. More than 2700 human miRNAs have been identified and some are known to be associated with disease phenotypes and to display tissue-specific patterns of expression. ME...

journal_title：BMC genomics

authors： Wake C,Labadorf A,Dumitriu A,Hoss AG,Bregu J,Albrecht KH,DeStefano AL,Myers RH

更新日期：2016-10-04 00:00:00

abstract：BACKGROUND:Leishmania (L) are intracellular protozoan parasites that are able to survive and replicate within the harsh and potentially hostile phagolysosomal environment of mammalian mononuclear phagocytes. A complex interplay then takes place between the macrophage (MPhi) striving to eliminate the pathogen and the pa...

journal_title：BMC genomics

authors： Guerfali FZ,Laouini D,Guizani-Tabbane L,Ottones F,Ben-Aissa K,Benkahla A,Manchon L,Piquemal D,Smandi S,Mghirbi O,Commes T,Marti J,Dellagi K

更新日期：2008-05-21 00:00:00

abstract：BACKGROUND:The tropical green-lipped mussel Perna viridis is a common biomonitor throughout the Indo-Pacific region that is used for environmental monitoring and ecotoxicological investigations. However, there is limited molecular data available regarding this species. We sought to establish a global transcriptome data...

journal_title：BMC genomics

authors： Leung PT,Ip JC,Mak SS,Qiu JW,Lam PK,Wong CK,Chan LL,Leung KM

更新日期：2014-09-19 00:00:00

abstract：BACKGROUND:Despite the importance of wheat as a major staple crop and the negative impact of diseases on its production worldwide, the genetic mechanisms and gene interactions involved in the resistance response in wheat are still poorly understood. The complete sequence of the rice genome has provided an extremely use...

journal_title：BMC genomics

authors： Cantu D,Yang B,Ruan R,Li K,Menzo V,Fu D,Chern M,Ronald PC,Dubcovsky J

更新日期：2013-03-12 00:00:00

abstract：BACKGROUND:About 10% of cases of male infertility are due to the presence of microdeletions within the long arm of the Y chromosome (Yq). Despite the large literature covering this critical issue, very little is known about the pathogenic mechanism leading to spermatogenesis disruption in patients carrying these microd...

journal_title：BMC genomics

authors： Gatta V,Raicu F,Ferlin A,Antonucci I,Scioletti AP,Garolla A,Palka G,Foresta C,Stuppia L

更新日期：2010-06-24 00:00:00

abstract：BACKGROUND:The σ(54) subunit controls a unique class of promoters in bacteria. Such promoters, without exception, require enhancer binding proteins (EBPs) for transcription initiation. Desulfovibrio vulgaris Hildenborough, a model bacterium for sulfate reduction studies, has a high number of EBPs, more than most sequen...

journal_title：BMC genomics

authors： Kazakov AE,Rajeev L,Chen A,Luning EG,Dubchak I,Mukhopadhyay A,Novichkov PS

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:Simple Sequence Repeats (SSRs) are widely used in population genetic studies but their classical development is costly and time-consuming. The ever-increasing available DNA datasets generated by high-throughput techniques offer an inexpensive alternative for SSRs discovery. Expressed Sequence Tags (ESTs) hav...

journal_title：BMC genomics

authors： Lopez L,Barreiro R,Fischer M,Koch MA

更新日期：2015-10-13 00:00:00

abstract：BACKGROUND:The gut of phloem feeding insects is critical for nutrition uptake and xenobiotics degradation. However, partly due to its tiny size, genomic information for the gut of phloem feeding insects is limited. RESULTS:In this study, the gut transcriptomes of two species of invasive whiteflies in the Bemisia tabac...

journal_title：BMC genomics

authors： Ye XD,Su YL,Zhao QY,Xia WQ,Liu SS,Wang XW

更新日期：2014-05-15 00:00:00

abstract：BACKGROUND:Laboratory evolution is an important tool for developing robust yeast strains for bioethanol production since the biological basis behind combined tolerance requires complex alterations whose proper regulation is difficult to achieve by rational metabolic engineering. Previously, we reported on the evolved i...

journal_title：BMC genomics

authors： Wallace-Salinas V,Brink DP,Ahrén D,Gorwa-Grauslund MF

更新日期：2015-07-09 00:00:00

abstract：BACKGROUND:Toxigenic Vibrio cholerae serogroup O1 is the causative pathogen in the sixth and seventh cholera pandemics. Cholera toxin is the major virulent factor but other virulence and virulence-related factors play certain roles in the pathogenesis and survival in the host. Along with the evolution of the epidemic s...

journal_title：BMC genomics

authors： Li Z,Pang B,Wang D,Li J,Xu J,Fang Y,Lu X,Kan B

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:Bacterial phenotype may be profoundly affected by the physical arrangement of their genes in the genome. The Gram-negative species Aggregatibacter actinomycetemcomitans is a major etiologic agent of human periodontitis. Individual clonal types of A. actinomycetemcomitans may exhibit variable virulence and di...

journal_title：BMC genomics

authors： Kittichotirat W,Bumgarner R,Chen C

更新日期：2010-09-08 00:00:00

abstract：BACKGROUND:It is well understood that distinct communities of bacteria are present at different sites of the body, and that changes in the structure of these communities have strong implications for human health. Yet, challenges remain in understanding the complex interconnections between the bacterial taxa within thes...

journal_title：BMC genomics

authors： Fernandez M,Riveros JD,Campos M,Mathee K,Narasimhan G

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Cryptocaryon irritans is an obligate parasitic ciliate protozoan that can infect various commercially important mariculture fish species and cause high lethality and economic loss. Current methods of controlling this parasite with chemicals or antibiotics are widely considered to be environmentally harmful. ...

journal_title：BMC genomics

authors： Chen R,Mao Y,Wang J,Liu M,Qiao Y,Zheng L,Su Y,Ke Q,Zheng W

更新日期：2018-03-12 00:00:00

abstract：BACKGROUND:Sand fly saliva plays an important role in blood feeding and Leishmania transmission as it was shown to increase parasite virulence. On the other hand, immunity to salivary components impedes the establishment of infection. Therefore, it is most desirable to gain a deeper insight into the composition of sali...

journal_title：BMC genomics

authors： Hostomská J,Volfová V,Mu J,Garfield M,Rohousová I,Volf P,Valenzuela JG,Jochim RC

更新日期：2009-06-25 00:00:00

abstract：BACKGROUND:Obesity, the excessive accumulation of body fat, is a highly heritable and genetically heterogeneous disorder. The complex, polygenic basis for the disease consisting of a network of different gene variants is still not completely known. RESULTS:In the current study we generated a BAC library of the obese-p...

journal_title：BMC genomics

authors： Vogel H,Jähnert M,Stadion M,Matzke D,Scherneck S,Schürmann A

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:RNA-seq and small RNA-seq are powerful, quantitative tools to study gene regulation and function. Common high-throughput sequencing methods rely on polymerase chain reaction (PCR) to expand the starting material, but not every molecule amplifies equally, causing some to be overrepresented. Unique molecular i...

journal_title：BMC genomics

authors： Fu Y,Wu PH,Beane T,Zamore PD,Weng Z

更新日期：2018-07-13 00:00:00

abstract：BACKGROUND:Interactions between fish and pathogens, that may be harmless under natural conditions, often result in serious diseases in aquaculture systems. This is especially important due to the fact that the strains used in aquaculture are derived from wild strains that may not have had enough time to adapt to new di...

journal_title：BMC genomics

authors： Rodríguez-Ramilo ST,Toro MA,Bouza C,Hermida M,Pardo BG,Cabaleiro S,Martínez P,Fernández J

更新日期：2011-11-02 00:00:00

abstract：BACKGROUND:Sclerotinia sclerotiorum is a broad-host range necrotrophic pathogen which is the causative agent of Sclerotinia stem rot (SSR), and a major disease of soybean (Glycine max). A time course transcriptomic analysis was performed in both compatible and incompatible soybean lines to identify pathogenicity and de...

journal_title：BMC genomics

authors： Westrick NM,Ranjan A,Jain S,Grau CR,Smith DL,Kabbage M

更新日期：2019-02-26 00:00:00

abstract：BACKGROUND:Yarrowia lipolytica is an oleaginous ascomycete yeast that stores lipids in response to limitation of nitrogen. While the enzymatic pathways responsible for neutral lipid accumulation in Y. lipolytica are well characterized, regulation of these pathways has received little attention. We therefore sought to c...

journal_title：BMC genomics

authors： Pomraning KR,Kim YM,Nicora CD,Chu RK,Bredeweg EL,Purvine SO,Hu D,Metz TO,Baker SE

更新日期：2016-02-25 00:00:00

abstract：BACKGROUND:Human leucocyte antigen (HLA) genes play an important role in determining the outcome of organ transplantation and are linked to many human diseases. Because of the diversity and polymorphisms of HLA loci, HLA typing at high resolution is challenging even with whole-genome sequencing data. RESULTS:We have d...

journal_title：BMC genomics

authors： Nariai N,Kojima K,Saito S,Mimori T,Sato Y,Kawai Y,Yamaguchi-Kabata Y,Yasuda J,Nagasaki M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Belonging to lineage I of Brassicaceae, Camelina sativa is formed by two hybridizations of three species (three sub-genomes). The three sub-genomes were diverged from a common ancestor, likely derived from lineage I (Ancestral Crucifer karyotype, ACK). The karyotype evolutionary trajectories of the C. sativa...

journal_title：BMC genomics

authors： Zhang Z,Meng F,Sun P,Yuan J,Gong K,Liu C,Wang W,Wang X

更新日期：2020-10-12 00:00:00

abstract：BACKGROUND:Improvements in poultry production within the past 50 years have led to increased muscle yield and growth rate, which may be contributing to an increased rate and development of new muscle disorders in chickens. Previously reported muscle disorders and conditions are generally associated with poor meat quali...

journal_title：BMC genomics

authors： Mutryn MF,Brannick EM,Fu W,Lee WR,Abasht B

更新日期：2015-05-21 00:00:00

abstract：BACKGROUND:The genomic architecture of adaptive traits remains poorly understood in non-model plants. Various approaches can be used to bridge this gap, including the mapping of quantitative trait loci (QTL) in pedigrees, and genetic association studies in non-structured populations. Here we present results on the geno...

journal_title：BMC genomics

authors： Prunier J,Pelgas B,Gagnon F,Desponts M,Isabel N,Beaulieu J,Bousquet J

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Aluminium (Al) toxicity is the main factor limiting the crop production in acid soils and barley (Hordeum vulgare L.) is one of the most Al-sensitive of the small-grained cereals. The major gene for Al tolerance in barley is HvAACT1 (HvMATE) on chromosome 4H which encodes a multidrug and toxic compound extru...

journal_title：BMC genomics

authors： Ma Y,Li C,Ryan PR,Shabala S,You J,Liu J,Liu C,Zhou M

更新日期：2016-03-05 00:00:00

abstract：BACKGROUND:Transposable elements constitute a significant fraction of plant genomes. The PIF/Harbinger superfamily includes DNA transposons (class II elements) carrying terminal inverted repeats and producing a 3 bp target site duplication upon insertion. The presence of an ORF coding for the DDE/DDD transposase, requi...

journal_title：BMC genomics

authors： Grzebelus D,Lasota S,Gambin T,Kucherov G,Gambin A

更新日期：2007-11-09 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：BMC genomics

authors： Levin M,Scheibe M,Butter F

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:Galileo is one of three members of the P superfamily of DNA transposons. It was originally discovered in Drosophila buzzatii, in which three segregating chromosomal inversions were shown to have been generated by ectopic recombination between Galileo copies. Subsequently, Galileo was identified in six of 12 ...

journal_title：BMC genomics

authors： Gonçalves JW,Valiati VH,Delprat A,Valente VL,Ruiz A

更新日期：2014-09-13 00:00:00