A vast genomic deletion in the C56BL/6 genome affects different genes within the Ifi200 cluster on chromosome 1 and mediates obesity and insulin resistance.

abstract：BACKGROUND:Chlamydomonas reinhardtii is the model organism that serves as a reference for studies in algal genomics and physiology. It is of special interest in the study of the evolution of regulatory pathways from algae to higher plants. Additionally, it has recently gained attention as a potential source for bio-fue...

journal_title：BMC genomics

authors： Romero-Campero FJ,Perez-Hurtado I,Lucas-Reina E,Romero JM,Valverde F

更新日期：2016-03-12 00:00:00

abstract：BACKGROUND:Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identified in the public available small RNA sequencing data sets. RESULTS:In this study, we identified a...

journal_title：BMC genomics

authors： Liu YC,Chen WL,Kung WH,Huang HD

更新日期：2017-03-14 00:00:00

abstract：BACKGROUND:Alternative splicing (AS) regulation is extensive and shapes the functional complexity of higher organisms. However, the contribution of alternative splicing to fungal biology is not well studied. RESULTS:This study provides sequences of the transcriptomes of the plant wilt pathogen Verticillium dahliae, us...

journal_title：BMC genomics

authors： Jin L,Li G,Yu D,Huang W,Cheng C,Liao S,Wu Q,Zhang Y

更新日期：2017-02-06 00:00:00

abstract：BACKGROUND:Antimicrobial resistance is one of our most serious health threats. Antimicrobial peptides (AMPs), effecter molecules of innate immune system, can defend host organisms against microbes and most have shown a lowered likelihood for bacteria to form resistance compared to many conventional drugs. Thus, AMPs ar...

journal_title：BMC genomics

authors： Fu H,Cao Z,Li M,Wang S

更新日期：2020-08-28 00:00:00

abstract：BACKGROUND:The variability in gene organization and architecture of green algal mitochondrial genomes is only recently being studied on a finer taxonomic scale. Sequenced mt genomes from the chlorophycean orders Volvocales and Sphaeropleales exhibit considerable variation in size, content, and structure, even among clo...

journal_title：BMC genomics

authors： Farwagi AA,Fučíková K,McManus HA

更新日期：2015-10-21 00:00:00

abstract：BACKGROUND:Using a combination of pyrosequencing and conventional Sanger sequencing, the complete genome sequence of the recently described novel Brucella species, Brucella microti, was determined. B. microti is a member of the genus Brucella within the Alphaproteobacteria, which consists of medically important highly ...

journal_title：BMC genomics

authors： Audic S,Lescot M,Claverie JM,Scholz HC

更新日期：2009-08-04 00:00:00

abstract：BACKGROUND:Cryptocaryon irritans is an obligate parasitic ciliate protozoan that can infect various commercially important mariculture fish species and cause high lethality and economic loss. Current methods of controlling this parasite with chemicals or antibiotics are widely considered to be environmentally harmful. ...

journal_title：BMC genomics

authors： Chen R,Mao Y,Wang J,Liu M,Qiao Y,Zheng L,Su Y,Ke Q,Zheng W

更新日期：2018-03-12 00:00:00

abstract：BACKGROUND:Microarray-based Comparative Genomic Hybridisation (CGH) has been used to assess genetic variability between bacterial strains. Crucial for interpretation of microarray data is the availability of a reference to compare signal intensities to reliably determine presence or divergence each DNA fragment. Howeve...

journal_title：BMC genomics

authors： Carpaij N,Fluit AC,Lindsay JA,Bonten MJ,Willems RJ

更新日期：2009-11-13 00:00:00

abstract：BACKGROUND:Gene expression analysis by reverse transcription quantitative PCR (qPCR) is the most widely used method for analyzing the expression of a moderate number of genes and also for the validation of microarray results. Several issues are crucial for a successful qPCR study, particularly the selection of internal...

journal_title：BMC genomics

authors： Robledo D,Hernández-Urcera J,Cal RM,Pardo BG,Sánchez L,Martínez P,Viñas A

更新日期：2014-08-04 00:00:00

abstract：BACKGROUND:Bovine papillomavirus (BPV) belongs to the Papillomaviridae family and infects epithelial cells of bovines and closely related animals, causing hyperproliferative lesions known as warts or papillomas, which may regress or progress to form benign or malignant tumors. The virus enters the host cell and interac...

journal_title：BMC genomics

authors： Barreto DM,Barros GS,Santos LABO,Soares RC,Batista MVA

更新日期：2018-12-19 00:00:00

abstract：BACKGROUND:The Ion Torrent PGM is a popular benchtop sequencer that shows promise in replacing conventional Sanger sequencing as the gold standard for mutation detection. Despite the PGM's reported high accuracy in calling single nucleotide variations, it tends to generate many false positive calls in detecting inserti...

journal_title：BMC genomics

authors： Yeo ZX,Wong JC,Rozen SG,Lee AS

更新日期：2014-06-24 00:00:00

abstract：BACKGROUND:Foraminiferan protists, which are significant players in most marine ecosystems, are also genetic innovators, harboring unique modifications to proteins that make up the basic eukaryotic cell machinery. Despite their ecological and evolutionary importance, foraminiferan genomes are poorly understood due to t...

journal_title：BMC genomics

authors： Habura A,Hou Y,Reilly AA,Bowser SS

更新日期：2011-03-31 00:00:00

abstract：BACKGROUND:Sugarcane is a major sugar and biofuel crop, but genomic research and molecular breeding have lagged behind other major crops due to the complexity of auto-allopolyploid genomes. Sugarcane cultivars are frequently aneuploid with chromosome number ranging from 100 to 130, consisting of 70-80 % S. officinarum,...

journal_title：BMC genomics

authors： Zhang J,Sharma A,Yu Q,Wang J,Li L,Zhu L,Zhang X,Chen Y,Ming R

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:Whilst adaptive facultative sex allocation has been widely studied at the phenotypic level across a broad range of organisms, we still know remarkably little about its genetic architecture. Here, we explore the genome-wide basis of sex ratio variation in the parasitoid wasp Nasonia vitripennis, perhaps the b...

journal_title：BMC genomics

authors： Pannebakker BA,Cook N,van den Heuvel J,van de Zande L,Shuker DM

更新日期：2020-07-20 00:00:00

abstract：BACKGROUND:Various cancer cells, including those of colorectal cancer (CRC), release microvesicles (exosomes) into surrounding tissues and peripheral circulation. These microvesicles can mediate communication between cells and affect various tumor-related processes in their target cells. RESULTS:We present potential r...

journal_title：BMC genomics

authors： Hong BS,Cho JH,Kim H,Choi EJ,Rho S,Kim J,Kim JH,Choi DS,Kim YK,Hwang D,Gho YS

更新日期：2009-11-25 00:00:00

abstract：BACKGROUND:Low iron bioavailability is a common feature of ocean surface water and therefore micro-algae developed original strategies to optimize iron uptake and metabolism. The marine picoeukaryotic green alga Ostreococcus tauri is a very good model for studying physiological and genetic aspects of the adaptation of ...

journal_title：BMC genomics

authors： Lelandais G,Scheiber I,Paz-Yepes J,Lozano JC,Botebol H,Pilátová J,Žárský V,Léger T,Blaiseau PL,Bowler C,Bouget FY,Camadro JM,Sutak R,Lesuisse E

更新日期：2016-05-03 00:00:00

abstract：BACKGROUND:Sclerotinia Stem Rot (SSR), caused by the fungal pathogen Sclerotinia sclerotiorum, is ubiquitous in cooler climates where soybean crops are grown. Breeding for resistance to SSR remains challenging in crops like soybean, where no single gene provides strong resistance, but instead, multiple genes work toget...

journal_title：BMC genomics

authors： Wei W,Mesquita ACO,Figueiró AA,Wu X,Manjunatha S,Wickland DP,Hudson ME,Juliatti FC,Clough SJ

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:Subtilisin/kexin-like proprotein convertase (PCSK) enzymes have important regulatory function in a wide variety of biological processes. PCSKs proteolytically process at a target sequence that contains basic amino acids arginine and lysine, which results in functional maturation of the target protein. In vit...

journal_title：BMC genomics

authors： Turpeinen H,Kukkurainen S,Pulkkinen K,Kauppila T,Ojala K,Hytönen VP,Pesu M

更新日期：2011-12-20 00:00:00

abstract：BACKGROUND:Tandemly arranged nuclear ribosomal DNA (rDNA), encoding 18S, 5.8S and 26S ribosomal RNA (rRNA), exhibit concerted evolution, a pattern thought to result from the homogenisation of rDNA arrays. However rDNA homogeneity at the single nucleotide polymorphism (SNP) level has not been detailed in organisms with ...

journal_title：BMC genomics

authors： Matyášek R,Renny-Byfield S,Fulneček J,Macas J,Grandbastien MA,Nichols R,Leitch A,Kovařík A

更新日期：2012-12-23 00:00:00

abstract：BACKGROUND:There are no commercially available vaccines against human protozoan parasitic diseases, despite the success of vaccination-induced long-term protection against infectious diseases. East Coast fever, caused by the protist Theileria parva, kills one million cattle each year in sub-Saharan Africa, and contribu...

journal_title：BMC genomics

authors： Norling M,Bishop RP,Pelle R,Qi W,Henson S,Drábek EF,Tretina K,Odongo D,Mwaura S,Njoroge T,Bongcam-Rudloff E,Daubenberger CA,Silva JC

更新日期：2015-09-24 00:00:00

abstract：BACKGROUND:Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is lethal. In contrast, dystrophin-deficient mdx mice recover due to effective regeneration of affected muscle tissue. To characterize the molecular processes associated with regeneration, we compared gene expression levels in hin...

journal_title：BMC genomics

authors： Turk R,Sterrenburg E,de Meijer EJ,van Ommen GJ,den Dunnen JT,'t Hoen PA

更新日期：2005-07-13 00:00:00

abstract：BACKGROUND:Lysophosphatidic acid acyltransferase (LPAAT) encoded by a multigene family is a rate-limiting enzyme in the Kennedy pathway in higher plants. Cotton is the most important natural fiber crop and one of the most important oilseed crops. However, little is known on genes coding for LPAATs involved in oil biosy...

journal_title：BMC genomics

authors： Wang N,Ma J,Pei W,Wu M,Li H,Li X,Yu S,Zhang J,Yu J

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The tuberous root of sweet potato is an important agricultural and biological organ. There are not sufficient transcriptomic and genomic data in public databases for understanding of the molecular mechanism underlying the tuberous root formation and development. Thus, high throughput transcriptome sequencing...

journal_title：BMC genomics

authors： Wang Z,Fang B,Chen J,Zhang X,Luo Z,Huang L,Chen X,Li Y

更新日期：2010-12-24 00:00:00

abstract：BACKGROUND:Limited nutrient availability during development is associated with metabolic diseases in adulthood. The molecular cause for these defects is unclear. Here, we investigate if transcriptional changes caused by developmental malnutrition reveal an early response that can be linked to metabolism and metabolic d...

journal_title：BMC genomics

authors： Huang Y,Linsen SE

更新日期：2015-06-04 00:00:00

abstract：BACKGROUND:Efforts towards utilisation of diets without fish meal (FM) or fish oil (FO) in finfish aquaculture have been being made for more than two decades. Metabolic responses to substitution of fishery products have been shown to impact growth performance and immune system of fish as well as their subsequent nutrit...

journal_title：BMC genomics

authors： Geay F,Ferraresso S,Zambonino-Infante JL,Bargelloni L,Quentel C,Vandeputte M,Kaushik S,Cahu CL,Mazurais D

更新日期：2011-10-23 00:00:00

abstract：BACKGROUND:Pectobacterium spp. are necrotrophic bacterial plant pathogens of the family Pectobacteriaceae, responsible for a wide spectrum of diseases of important crops and ornamental plants including soft rot, blackleg, and stem wilt. P. carotovorum is a genetically heterogeneous species consisting of three valid sub...

journal_title：BMC genomics

authors： Li X,Ma Y,Liang S,Tian Y,Yin S,Xie S,Xie H

更新日期：2018-12-07 00:00:00

abstract：BACKGROUND:Belonging to lineage I of Brassicaceae, Camelina sativa is formed by two hybridizations of three species (three sub-genomes). The three sub-genomes were diverged from a common ancestor, likely derived from lineage I (Ancestral Crucifer karyotype, ACK). The karyotype evolutionary trajectories of the C. sativa...

journal_title：BMC genomics

authors： Zhang Z,Meng F,Sun P,Yuan J,Gong K,Liu C,Wang W,Wang X

更新日期：2020-10-12 00:00:00

abstract：BACKGROUND:Venomous animals incapacitate their prey using complex venoms that can contain hundreds of unique protein toxins. The realisation that many of these toxins may have pharmaceutical and insecticidal potential due to their remarkable potency and selectivity against target receptors has led to an explosion in th...

journal_title：BMC genomics

authors： Wood DL,Miljenović T,Cai S,Raven RJ,Kaas Q,Escoubas P,Herzig V,Wilson D,King GF

更新日期：2009-08-13 00:00:00

abstract：BACKGROUND:Wheat is the most important staple crop in Afghanistan and accounts for the main part of cereal production. However, wheat production has been unstable during the last decades and the country depends on seed imports. Wheat research in Afghanistan has emphasized releases of new, high-yielding and disease resi...

journal_title：BMC genomics

authors： Dreisigacker S,Sharma RK,Huttner E,Karimov A,Obaidi MQ,Singh PK,Sansaloni C,Shrestha R,Sonder K,Braun HJ

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:Spiders (Order Araneae) are essential predators in every terrestrial ecosystem largely because they have evolved potent arsenals of silk and venom. Spider silks are high performance materials made almost entirely of proteins, and thus represent an ideal system for investigating genome level evolution of nove...

journal_title：BMC genomics

authors： Clarke TH,Garb JE,Hayashi CY,Haney RA,Lancaster AK,Corbett S,Ayoub NA

更新日期：2014-05-23 00:00:00