Abstract:
:The insulin-like growth factor-1 (IGF-1) plays an important role in the regulation of reproductive function. In the present study, we examined the effects of caloric restriction (CR) on the reproductive lifespan in rats and investigated the potential role of IGF-1. After 10 weeks of treatment, we determined the distribution of the ovarian follicles at various stages and measured the plasma level of IGF-1, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estrogen (ESG). Our results show that IGF-1 level was decreased after CR and correlated with the decrease in the levels of LH, FSH and ESG. Moreover, a higher percentage of primordial follicles and surviving follicles was observed in CR rats than in control rats (P<0.05). Immunohistochemical analysis showed that IGF-1 was extensively expressed in the cytoplasm of granulosa cells in the surviving follicles at different stages but not in the atretic follicles. Taken together, these results suggest that caloric restriction promotes the reproductive capacity of female rats via modulating the level of IGF-1, which then regulate pituitary gonadotrope cells to reduce the release of LH, FSH and ESG, and modulate follicular development.
journal_name
Gen Comp Endocrinoljournal_title
General and comparative endocrinologyauthors
Li L,Fu YC,Xu JJ,Chen XC,Lin XH,Luo LLdoi
10.1016/j.ygcen.2011.09.005subject
Has Abstractpub_date
2011-11-01 00:00:00pages
232-7issue
2eissn
0016-6480issn
1095-6840pii
S0016-6480(11)00361-3journal_volume
174pub_type
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