Abstract：
BACKGROUND:The development of efficacious alternatives to antimicrobial growth promoters (AGP) in livestock production is an urgent issue, but is hampered by a lack of knowledge regarding the mode of action of AGP. The belief that AGP modulate the intestinal microbiota has become prominent in the literature; however, there is a lack of experimental evidence to support this hypothesis. Using a chlortetracycline-murine-Citrobacter rodentium model, the ability of AGP to modulate the intestinal immune system in mammals was investigated. RESULTS:C. rodentium was transformed with the tetracycline resistance gene, tetO, and continuous oral administration of a non-therapeutic dose of chlortetracycline to mice did not affect densities of C. rodentium CFU in feces throughout the experiment or associated with mucosal surfaces in the colon (i.e. at peak and late infection). However, chlortetracycline regulated transcription levels of Th1 and Th17 inflammatory cytokines in a temporal manner in C. rodentium-inoculated mice, and ameliorated weight loss associated with infection. In mice inoculated with C. rodentium, those that received chlortetracycline had less pathologic changes in the distal colon than mice not administered CTC (i.e. relative to untreated mice). Furthermore, chlortetracycline administration at a non-therapeutic dose did not impart either prominent or consistent effects on the colonic microbiota. CONCLUSION:Data support the hypothesis that AGP function by modulating the intestinal immune system in mammals. This finding may facilitate the development of biorationale-based and efficacious alternatives to AGP.
journal_name
Gut Pathogjournal_title
Gut pathogensauthors
Costa E,Uwiera RR,Kastelic JP,Selinger LB,Inglis GDdoi
10.1186/1757-4749-3-14subject
Has Abstractpub_date
2011-09-25 00:00:00pages
14issue
1issn
1757-4749pii
1757-4749-3-14journal_volume
3pub_type
杂志文章相关文献
Gut Pathogens文献大全abstract：BACKGROUND:The putative H. pylori pathogenicity-associated factor dupA has been associated with IL-8 induction in vitro, and duodenal ulcer (DU) and gastric cancer (GC) development in certain populations, but this association is inconsistent between studies. We aimed to investigate dupA prevalence in clinical isolates ...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/1757-4749-1-5
更新日期：2009-03-11 00:00:00
abstract：BACKGROUND:Campylobacter jejuni, a gram-negative bacterium, is a frequent cause of gastrointestinal food-borne illness in humans throughout the world. There are several reports that the virulence of C. jejuni might be modulated by non-flagellar proteins that are secreted through the filament. Recently, FspA (Flagella s...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/1757-4749-3-11
更新日期：2011-07-12 00:00:00
abstract：BACKGROUND:Acid treatment is commonly used for controlling or killing pathogenic microorganisms on medical devices and environments; however, inadequate acid treatment may cause acid tolerance response (ATR) and offer cross-protection against environmental stresses, including antimicrobials. This study aimed to charact...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/s13099-020-00390-5
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Enterotoxigenic Escherichia coli (ETEC) is an important pathogen that causes childhood and travelers' diarrhea. Here, we present the draft genomes of four ETEC isolates recovered from stool specimens of patients with diarrhea in Beijing, China and Dhaka, Bangladesh, respectively. RESULTS:We obtained the dra...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/s13099-015-0059-z
更新日期：2015-04-08 00:00:00
abstract：BACKGROUND:Typhoid fever has caused severe epidemics in many Asian and African countries. The early detection of outbreaks and their sources may promote the prevention and control of typhoid fever, for which effective and timely molecular subtyping techniques are required. Pulsed field gel electrophoresis (PFGE) is rou...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/s13099-016-0094-4
更新日期：2016-04-04 00:00:00
abstract：:[This corrects the article DOI: 10.1186/1757-4749-6-28.]. ...
journal_title：Gut pathogens
pub_type： 已发布勘误
doi：10.1186/s13099-016-0120-6
更新日期：2016-08-10 00:00:00
abstract：Background:After an environmental disaster, the affected community is at increased risk for persistent abdominal pain but mechanisms are unclear. Therefore, our study aimed to determine association between abdominal pain and poor water, sanitation and hygiene (WaSH) practices, and if small intestinal bacterial overgrow...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/s13099-017-0224-7
更新日期：2017-12-14 00:00:00
abstract：BACKGROUND:Inflammatory bowel disease (comprising ulcerative colitis and Crohn's disease) is a multifactorial disease that is extensively associated with stool microbiome changes (dysbiosis). Appendicitis and appendectomy limits subsequent colitis, clinically, and in animal models. We wanted to examine how the appendic...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/1757-4749-6-25
更新日期：2014-06-21 00:00:00
abstract：BACKGROUND:Intestinal microorganisms affect host physiology, including ageing. Given the difficulty in controlling for human studies of the gut microbiome, mouse models provide an alternative avenue to study such relationships. In this study, we report on the complete genome of "Faecalibaculum rodentium" ALO17, a bacte...
journal_title：Gut pathogens
pub_type：
doi：10.1186/s13099-016-0087-3
更新日期：2016-02-12 00:00:00
abstract：BACKGROUND:Campylobacter enteritis represents a risk factor for the development of inflammatory bowel disease (IBD) via unknown mechanisms. As IBD patients exhibit inflammatory responses to their commensal intestinal microflora, factors that induce translocation of commensal bacteria across the intestinal epithelium ma...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/1757-4749-1-2
更新日期：2009-02-03 00:00:00
abstract：BACKGROUND:One mechanism utilized by bacterial pathogens for host adaptation and immune evasion is the generation of phenotypic diversity by the phasevarion that results from the differential expression of a suite of genes regulated by the activity of a phase-variable methyltransferase within a restriction modification...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/s13099-014-0035-z
更新日期：2014-09-05 00:00:00
abstract：BACKGROUND:Serratia marcescens is an opportunistic bacterial pathogen with broad range of host ranging from vertebrates, invertebrates and plants. S. marcescens strain W2.3 was isolated from a diseased tilapia fish and it was suspected to be the causal agent for the fish disease as virulence genes were found within its...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/1757-4749-5-29
更新日期：2013-10-22 00:00:00
abstract：BACKGROUND:Widely considered probiotic organisms, Bifidobacteria are common inhabitants of the alimentary tract of animals including insects. Bifidobacteria identified from the honey bee are found in larval guts and throughout the alimentary tract, but attain their greatest abundance in the adult hind gut. To further u...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/1757-4749-5-42
更新日期：2013-12-18 00:00:00
abstract：BACKGROUND:In 2007, a nationwide Salmonella Tennessee outbreak occurred via contaminated peanut butter. Here, we developed a single-nucleotide polymorphism (SNP)-typing method for S. Tennessee to determine the clonal subtypes of S. Tennessee that were associated with the peanut butter outbreak. METHODS AND RESULTS:One...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/s13099-017-0176-y
更新日期：2017-05-01 00:00:00
abstract：:Rapid scientific and technological advances have allowed for a more detailed understanding of the relevance of intestinal microbiota, and the entire body-wide microbiome, to human health and well-being. Rodent studies have provided suggestive evidence that probiotics (e.g. lactobacillus and bifidobacteria) can influen...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/1757-4749-5-4
更新日期：2013-03-16 00:00:00
abstract：BACKGROUND:The human and animal intestinal tract harbors a complex community of microbes which enables bacteria to inherit antibiotic resistance genes. The aims of this study were to investigate clonality, antimicrobial resistance, prevalence and gene cassette arrays of class I and II integrons among commensal Escheric...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/s13099-016-0123-3
更新日期：2016-08-30 00:00:00
abstract：BACKGROUND:Helicobacter pylori infection is associated with risk for chronic gastritis (CG), gastric ulcer (GU), duodenal ulcer (DU), and gastric cancer (GC). The H. pylori Cag type IV secretion system (TFSS) translocates the virulence factor cytotoxin-associated gene A protein into host cells and plays an important ro...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/s13099-017-0165-1
更新日期：2017-04-21 00:00:00
abstract：BACKGROUND:Coeliac disease is an autoimmune disorder resulting from an interaction between diet, genome and immunity. The treatment of CoeD is lifelong adherence to a gluten free diet, which is associated with clinical and histological improvements. However, a substantive number of individuals report only partial sympt...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/s13099-017-0173-1
更新日期：2017-05-05 00:00:00
abstract：BACKGROUND:In 2005, the first disease-specific Helicobacter pylori virulence factor that induced duodenal ulcer and had a suppressive action on gastric cancer has been identified, and was named duodenal ulcer promoting gene (dupA). However, the importance of the dupA gene on clinical outcomes is conflicting in subseque...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/1757-4749-2-13
更新日期：2010-10-31 00:00:00
abstract：Background:Recent advances in next-generation sequencing technologies have enabled comprehensive analysis of the gut microbiota, which is closely linked to the health of the host. Consequently, several studies have explored the factors affecting gut microbiota composition. In recent years, increasing number of dog owne...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/s13099-017-0218-5
更新日期：2017-11-21 00:00:00
abstract：BACKGROUND:There are multiple etiologies responsible for infectious gastroenteritis causing acute diarrhea which are often under diagnosed. Also acute diarrhea is one of the major causes of morbidity and mortality among children less than 5 years of age. METHODS:In our study, fecal samples (n = 130) were collected fro...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/s13099-017-0166-0
更新日期：2017-04-11 00:00:00
abstract：UNLABELLED: BACKGROUND:Following Helicobacter pylori eradication in idiopathic parkinsonism (IP), hypokinesia improved but flexor-rigidity increased. Small intestinal bacterial-overgrowth (SIBO) is a candidate driver of the rigidity: hydrogen-breath-test-positivity is common in IP and case histories suggest that Helic...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/1757-4749-4-12
更新日期：2012-10-19 00:00:00
abstract：BACKGROUND:Thermotolerant Campylobacter jejuni, coli and lari are recognized as leading food-borne pathogens causing an acute bacterial enteritis worldwide. Due to narrow spectrum of their biochemical activity, it is very complicated to distinguish between individual species. For reliable risk assessment, proper incide...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/1757-4749-6-12
更新日期：2014-05-09 00:00:00
abstract：UNLABELLED: BACKGROUND:Helicobacter pylori are successful colonizers of the human gastric mucosa. Colonization increases the risk of peptic ulcer disease and adenocarcinoma. However, potential benefits of H. pylori colonization include protection against early-onset asthma and against gastrointestinal infections. Camp...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/1757-4749-4-9
更新日期：2012-08-24 00:00:00
abstract：BACKGROUND:Cronobacter sakazakii is an emerging opportunistic pathogen that is associated with rare but life-threatening cases of severe diseases: meningitis, necrotizing enterocolitis, and sepsis in premature and full-term infants. However, the pathogenesis mechanism of this pathogen remains largely unknown. To determ...
journal_title：Gut pathogens
pub_type：
doi：10.1186/s13099-016-0150-0
更新日期：2017-01-04 00:00:00
abstract：BACKGROUND:Recent epidemiological analyses have implicated acute Campylobacter enteritis as a factor that may incite or exacerbate inflammatory bowel disease (IBD) in susceptible individuals. We have demonstrated previously that C. jejuni disrupts the intestinal barrier function by rapidly inducing epithelial transloca...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/1757-4749-2-14
更新日期：2010-11-01 00:00:00
abstract：Background:The human gut microbiome has an important role in health and disease. There is extensive geographical variation in the composition of the gut microbiome, however, little is known about the gut microbiome composition of people from the Arabian Peninsula. In this study, we describe the gut microbiome of Arab K...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/s13099-020-00351-y
更新日期：2020-02-26 00:00:00
abstract：BACKGROUND:Ruminants serve as one of the most important reservoirs for pathogenic Escherichia coli. Infection with E. coli, a foodborne enteropathogen, can lead to asymptomatic infections that can cause life-threatening complications in humans. Therefore, from a clinical and human health perspective, it is important to...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/s13099-017-0174-0
更新日期：2017-04-28 00:00:00
abstract：BACKGROUND:Clostridium difficile is an anaerobic Gram-positive spore-forming gut pathogen that causes antibiotic-associated diarrhea worldwide. A small number of C. difficile strains express the binary toxin (CDT), which is generally found in C. difficile 027 (ST1) and/or 078 (ST11) in clinic. However, we isolated a bi...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/s13099-017-0191-z
更新日期：2017-08-07 00:00:00
abstract：:The two-stage neuroinflammatory process, containment and progression, proposed to underlie neurodegeneration may predicate on systemic inflammation arising from the gastrointestinal tract. Helicobacter infection has been described as one switch in the pathogenic-circuitry of idiopathic parkinsonism (IP): eradication m...
journal_title：Gut pathogens
pub_type： 杂志文章
doi：10.1186/1757-4749-1-20
更新日期：2009-11-26 00:00:00
