Abstract:
UNLABELLED: BACKGROUND:Helicobacter pylori are successful colonizers of the human gastric mucosa. Colonization increases the risk of peptic ulcer disease and adenocarcinoma. However, potential benefits of H. pylori colonization include protection against early-onset asthma and against gastrointestinal infections. Campylobacter jejuni are a leading cause of bacterial diarrhea and complications include Guillain-Barré syndrome. Here, we describe the development of reliable serological assays to detect antibodies against those two bacteria in Rhesus macaques and investigated their distribution within a social group of monkeys. METHODS:Two cohorts of monkeys were analyzed. The first cohort consisted of 30 monkeys and was used to establish an enzyme-linked immunosorbent assay (ELISA) for H. pylori antibodies detection. To evaluate colonization of those macaques, stomach biopsies were collected and analyzed for the presence of H. pylori by histology and culture. C. jejuni ELISAs were established using human serum with known C. jejuni antibody status. Next, plasma samples of the 89 macaques (Cohort 2) were assayed for antibodies and then statistically analyzed. RESULTS:An H. pylori IgG ELISA, which was 100% specific and 93% sensitive, was established. In contrast, the IgA ELISA was only 82% specific and 61% sensitive. The CagA IgG assay was 100% sensitive and 61% of the macaques were positive. In cohort 2, 62% macaques were H. pylori sero-positive and 52% were CagA positive. The prevalence of H. pylori IgG and CagA IgG increased with monkey age as described for humans. Of the 89 macaques 52% showed IgG against C. jejuni but in contrast to H. pylori, the sero-prevalence was not associated with increasing age. However, there was a drop in the IgG (but not in IgA) mean values between infant and juvenile macaques, similar to trends described in humans. CONCLUSIONS:Rhesus macaques have widespread exposure to H. pylori and C. jejuni, reflecting their social conditions and implying that Rhesus macaques might provide a model to study effects of these two important human mucosal bacteria on a population.
journal_name
Gut Pathogjournal_title
Gut pathogensauthors
Kienesberger S,Perez-Perez GI,Rivera-Correa JL,Tosado-Acevedo R,Li H,Dubois A,Gonzalez-Martinez JA,Dominguez-Bello MG,Blaser MJdoi
10.1186/1757-4749-4-9subject
Has Abstractpub_date
2012-08-24 00:00:00pages
9issue
1issn
1757-4749pii
1757-4749-4-9journal_volume
4pub_type
杂志文章相关文献
Gut Pathogens文献大全abstract::As the associations between the gut microbiota and numerous health outcomes become more evident, it is important to conduct longitudinal microbiome research to advance the field beyond the identification of associations. It is also necessary to include individuals who have historically been underrepresented in biomedi...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-019-0324-7
更新日期:2019-08-26 00:00:00
abstract:Background:Extended spectrum beta lactamase (ESBL)-producing extraintestinal pathogenic Escherichia coli infections are of global interest because of their clinical and economic impact. The ESBL resistance genes disseminate through plasmids, and are found in successful global lineages such as ST131 and ST648. The carri...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-018-0243-z
更新日期:2018-06-15 00:00:00
abstract:BACKGROUND:In 2005, the first disease-specific Helicobacter pylori virulence factor that induced duodenal ulcer and had a suppressive action on gastric cancer has been identified, and was named duodenal ulcer promoting gene (dupA). However, the importance of the dupA gene on clinical outcomes is conflicting in subseque...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-2-13
更新日期:2010-10-31 00:00:00
abstract:BACKGROUND:Salmonella enterica serovar Typhi (S. Typhi) exhibits unique characteristics as an intracellular human pathogen. It causes both acute and chronic infection with various disease manifestations in the human host only. The principal factors underlying the unique lifestyle of motility and biofilm forming ability...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-6-2
更新日期:2014-02-05 00:00:00
abstract:BACKGROUND:Although antimicrobial resistance and persistence of resistant bacteria in humans and animals are major health concerns worldwide, the impact of antimicrobial resistance on bacterial intestinal colonization in healthy domestic animals has only been rarely studied. We carried out a retrospective analysis of t...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-1-18
更新日期:2009-10-08 00:00:00
abstract:BACKGROUND:Multidrug resistance and, in particular, carbapenem resistance is spreading worldwide at an alarming rate, comprehending a variety of bacterial species and causing both nosocomial and community acquired outbursts. Early and efficient detection of infected patients or colonized carriers are mandatory steps in...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-6-13
更新日期:2014-05-19 00:00:00
abstract:BACKGROUND:Thermotolerant Campylobacter jejuni, coli and lari are recognized as leading food-borne pathogens causing an acute bacterial enteritis worldwide. Due to narrow spectrum of their biochemical activity, it is very complicated to distinguish between individual species. For reliable risk assessment, proper incide...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-6-12
更新日期:2014-05-09 00:00:00
abstract:Background:The root extract of Rhodiola rosea has historically been used in Europe and Asia as an adaptogen, and similar to ginseng and Shisandra, shown to display numerous health benefits in humans, such as decreasing fatigue and anxiety while improving mood, memory, and stamina. A similar extract in the Rhodiola fami...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-018-0239-8
更新日期:2018-03-20 00:00:00
abstract:BACKGROUND:Typhoid fever has caused severe epidemics in many Asian and African countries. The early detection of outbreaks and their sources may promote the prevention and control of typhoid fever, for which effective and timely molecular subtyping techniques are required. Pulsed field gel electrophoresis (PFGE) is rou...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-016-0094-4
更新日期:2016-04-04 00:00:00
abstract:BACKGROUND:Inflammatory bowel disease (comprising ulcerative colitis and Crohn's disease) is a multifactorial disease that is extensively associated with stool microbiome changes (dysbiosis). Appendicitis and appendectomy limits subsequent colitis, clinically, and in animal models. We wanted to examine how the appendic...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-6-25
更新日期:2014-06-21 00:00:00
abstract:BACKGROUND:Human parechovirus (HPeV) is a genus of virus in the family Picornaviridae, having two species A and B. HPeVs are common infectious agents, usually causing mild diarrhea and respiratory disease in young children. RESULTS:Here, we collected and sequenced the near complete genome sequences of 17 novel HPeVs f...
journal_title:Gut pathogens
pub_type:
doi:10.1186/s13099-016-0135-z
更新日期:2016-11-08 00:00:00
abstract::We evaluated the effects of the probiotic Escherichia coli Nissle 1917 (EcN) and the antibiotic Ciprofloxacin (Cipro) on mRNA expression of intestinal epithelial cells (IEC) in gnotobiotic (Gn) piglets colonized with a defined commensal microflora (DMF) and inoculated with human rotavirus (HRV) that infects IECs. We a...
journal_title:Gut pathogens
pub_type:
doi:10.1186/s13099-016-0148-7
更新日期:2016-12-13 00:00:00
abstract:Background:After an environmental disaster, the affected community is at increased risk for persistent abdominal pain but mechanisms are unclear. Therefore, our study aimed to determine association between abdominal pain and poor water, sanitation and hygiene (WaSH) practices, and if small intestinal bacterial overgrow...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-017-0224-7
更新日期:2017-12-14 00:00:00
abstract:BACKGROUND:Bacillus cereus is well known as a gastrointestinal pathogen that causes food-borne illness. In the present study, we sequenced the complete genome of B. cereus FORC_013 isolated from fried eel in South Korea. To extend our understanding of the genomic characteristics of FORC_013, we conducted a comparative ...
journal_title:Gut pathogens
pub_type:
doi:10.1186/s13099-017-0175-z
更新日期:2017-05-15 00:00:00
abstract::Potential biological roles of the Campylobacter jejuni genes cj0641, cj0774c and cj1663 were investigated. The proteins encoded by these genes showed sequence similarities to the phosphonate utilisation PhnH, K and L gene products of Escherichia coli. The genes cj0641, cj0774c and cj1663 were amplified from the pathog...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-1-13
更新日期:2009-06-25 00:00:00
abstract:BACKGROUND:Contamination from fecal bacteria in recreational waters is a major health concern since bacteria capable of causing human disease can be found in animal feces. The Dog Beach area of Ocean Beach in San Diego, California is a beach prone to closures due to high levels of fecal indicator bacteria (FIB). A pote...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-3-10
更新日期:2011-07-07 00:00:00
abstract:BACKGROUND:The human and animal intestinal tract harbors a complex community of microbes which enables bacteria to inherit antibiotic resistance genes. The aims of this study were to investigate clonality, antimicrobial resistance, prevalence and gene cassette arrays of class I and II integrons among commensal Escheric...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-016-0123-3
更新日期:2016-08-30 00:00:00
abstract:BACKGROUND:One mechanism utilized by bacterial pathogens for host adaptation and immune evasion is the generation of phenotypic diversity by the phasevarion that results from the differential expression of a suite of genes regulated by the activity of a phase-variable methyltransferase within a restriction modification...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-014-0035-z
更新日期:2014-09-05 00:00:00
abstract:BACKGROUND:We investigated the interaction of Mycobacterium avium subspecies paratuberculosis, M. bovis and M. tuberculosis and different glial cells (enteric glial and microglial cells) in order to evaluate the infecting ability of these microorganisms and the effects produced on these cells, such as the evaluation of...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-3-19
更新日期:2011-12-09 00:00:00
abstract::Of 19 environmental Escherichia coli (n = 12) and Klebsiella pneumoniae (n = 7) tested for quinolone resistance-related genes qnrA, qnrB, qnrC, qnrS and qepA, four each of E. coli and K. pneumoniae possessed qnrS, and another E. coli isolate possessed a new variant of qepA. This is the first detection of qepA in envir...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-017-0207-8
更新日期:2017-10-23 00:00:00
abstract:BACKGROUND:The development of efficacious alternatives to antimicrobial growth promoters (AGP) in livestock production is an urgent issue, but is hampered by a lack of knowledge regarding the mode of action of AGP. The belief that AGP modulate the intestinal microbiota has become prominent in the literature; however, t...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-3-14
更新日期:2011-09-25 00:00:00
abstract:BACKGROUND:One of the working mechanisms of probiotic bacteria is their ability to compete with pathogens. To define the probiotic properties of seven Lactic Acid Bacteria (LAB) strains, we tested them for survival in simulated gastro-intestinal conditions, antimicrobial activities, co-aggregative abilities, and interf...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-017-0162-4
更新日期:2017-03-06 00:00:00
abstract:Introduction:Quinolone prophylaxis is recommended for patients with advanced cirrhosis at high risk of spontaneous bacterial peritonitis (SBP) or with prior SBP. Yet, the impact of long-term antibiotic prophylaxis on the microbiome of these patients is poorly characterized. Methods:Patients with liver cirrhosis receiv...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-020-00389-y
更新日期:2020-10-30 00:00:00
abstract:BACKGROUND:Acid treatment is commonly used for controlling or killing pathogenic microorganisms on medical devices and environments; however, inadequate acid treatment may cause acid tolerance response (ATR) and offer cross-protection against environmental stresses, including antimicrobials. This study aimed to charact...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-020-00390-5
更新日期:2020-12-01 00:00:00
abstract:UNLABELLED: BACKGROUND:Following Helicobacter pylori eradication in idiopathic parkinsonism (IP), hypokinesia improved but flexor-rigidity increased. Small intestinal bacterial-overgrowth (SIBO) is a candidate driver of the rigidity: hydrogen-breath-test-positivity is common in IP and case histories suggest that Helic...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-4-12
更新日期:2012-10-19 00:00:00
abstract:BACKGROUND:Widely considered probiotic organisms, Bifidobacteria are common inhabitants of the alimentary tract of animals including insects. Bifidobacteria identified from the honey bee are found in larval guts and throughout the alimentary tract, but attain their greatest abundance in the adult hind gut. To further u...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-5-42
更新日期:2013-12-18 00:00:00
abstract:BACKGROUND:Cronobacter sakazakii is an emerging opportunistic pathogen that is associated with rare but life-threatening cases of severe diseases: meningitis, necrotizing enterocolitis, and sepsis in premature and full-term infants. However, the pathogenesis mechanism of this pathogen remains largely unknown. To determ...
journal_title:Gut pathogens
pub_type:
doi:10.1186/s13099-016-0150-0
更新日期:2017-01-04 00:00:00
abstract:BACKGROUND:How host cell glycosylation affects EPEC or EHEC O157:H7 invasion is unclear. This study investigated whether and how O-glycans were involved in EPEC or EHEC O157:H7 invasion into HT-29 cells. RESULTS:Lectin histochemical staining confirmed stronger staining with PNA, which labeled Galβ1, 3 GalNAc (core 1 s...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-015-0078-9
更新日期:2015-12-15 00:00:00
abstract:Background:Acute gastroenteritis (AGE) is diagnosed with a presentation of > 1 episode of vomiting and > 3 episodes of diarrhea in a 24-h period. Treatment is supportive, however, in severe cases antibacterial treatment may be indicated. Stool cultures can detect the responsible pathogenic bacteria and can guide antibi...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-020-00369-2
更新日期:2020-06-22 00:00:00
abstract::[This corrects the article DOI: 10.1186/1757-4749-6-28.]. ...
journal_title:Gut pathogens
pub_type: 已发布勘误
doi:10.1186/s13099-016-0120-6
更新日期:2016-08-10 00:00:00