Abstract:
OBJECTIVES:To describe the MRI features of gout tophi in the soft-tissues or joints of the limbs by low-field extremity-dedicated MRI. METHODS:Nine consecutive patients, 8M/1W, affected by chronic tophaceous gout were studied. Mean patients' age was 71.3±11.5 years, mean disease duration 98.1±44.9 months, and mean serum uric acid concentration 9.2±2.8 mg/L. Diagnosis was based on the ACR classification criteria for gout, and by identification of MSU crystals in the tophi and synovial fluid. Conventional radiograms and MRI with an extremity-dedicated system were obtained of the joint areas involved by tophi. RESULTS:At T1 weighted MRI images, all tophi showed a homogeneous intermediate signal intensity, similar to that of muscle. Conversely, in T2 weighted images, a wide spectrum of signal intensity patterns was observed. The pattern of contrast enhancement was variable from intense homogeneous to peripheral and heterogeneous. Capsulo-ligamentous structures were often thickened and degenerated and, on occasion, could be recognised as inhomogeneous, hypointense ribbon-shaped elements in the context of the tophus. In only two cases, tendons were infiltrated by tophaceous matter. Bone marrow oedema (BME) and erosions were seen in 8 out of 10 bones adjacent to tophi. CONCLUSIONS:The MRI appearance of gout tophi using an extremity-dedicated machine is similar to that described in the literature using whole body machines. BME adjacent to the tophus was a frequent finding. This technique may occasionally help in the differential diagnosis of nodules and in the follow-up of the disease. It also represents a useful tool to investigate the pathogenesis of gout and to better understand its clinical progression.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Paparo F,Zampogna G,Fabbro E,Parodi M,Andracco R,Ferrero G,Garlaschi G,Cimmino MAsubject
Has Abstractpub_date
2011-05-01 00:00:00pages
519-26issue
3eissn
0392-856Xissn
1593-098Xpii
4300journal_volume
29pub_type
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,多中心研究,随机对照试验
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doi:
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journal_title:Clinical and experimental rheumatology
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doi:
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pub_type: 临床试验,杂志文章
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Clinical and experimental rheumatology
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doi:
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:2003-09-01 00:00:00
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journal_title:Clinical and experimental rheumatology
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更新日期:1989-05-01 00:00:00
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更新日期:2010-03-01 00:00:00
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更新日期:2019-01-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
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journal_title:Clinical and experimental rheumatology
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doi:
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doi:
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更新日期:2017-05-01 00:00:00
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更新日期:2017-03-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2016-09-01 00:00:00
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