当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Cytotoxicity and genotoxicity of chitooligosaccharides upon lymphocytes.

Cytotoxicity and genotoxicity of chitooligosaccharides upon lymphocytes.

Abstract：

:Two COS mixtures and a low molecular weight chitosan (LMWC) were tested for potential cytotoxicity and genotoxicity upon human lymphocytes. Genotoxicity was evaluated in vitro by cytokinesis-blocked micronucleus and alkaline comet assays, while cytotoxicity was assessed by flow cytometry analysis. Our results suggest that COS do not exhibit any genotoxicity upon human lymphocytes, independently of MW or concentration. However, above 0.07mg/mL COS induced strong cytotoxic effects. According to the concentration used, such cytotoxicity will induce cell death, essentially by necrosis (>0.10mg/mL) and/or apoptosis (<0.10mg/mL). The level of necrosis/apoptosis induced by high COS concentrations, suggests a promising use as apoptosis inducers in specific cancer situations.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Fernandes JC,Borges M,Nascimento H,Bronze-da-Rocha E,Ramos OS,Pintado ME,Malcata FX,Santos-Silva A

doi

10.1016/j.ijbiomac.2011.05.032

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

433-8

issue

3

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(11)00227-3

journal_volume

49

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Evaluation of BP-M-CPF4 polyhydroxyalkanoate (PHA) synthase on the production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from plant oil using Cupriavidus necator transformants.

    abstract：:Among the various types of polyhydroxyalkanoate (PHA), poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] [P(3HB-co-3HHx)] has a high potential to serve as commercial bioplastic due to its striking resemblance to petroleum-based plastics. In this study, five different genotypes of Cupriavidusnecator transformants h...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.05.064

    authors： Tan HT,Chek MF,Lakshmanan M,Foong CP,Hakoshima T,Sudesh K

    更新日期：2020-09-15 00:00:00

  • Phospholipase D from Allium sativum bulbs: A highly active and thermal stable enzyme.

    abstract：:This is the first report on the identification and partial characterization of phospholipase D (EC 3.1.4.4) from Allium sativum (garlic) bulbs (PLD(GB)). The enzyme shares the phenomenon of interfacial activation with other lipolytic enzymes, i.e. the hydrolytic rate increases when the substrate changes to a more aggr...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2008.01.007

    authors： Khatoon H,Talat S,Younus H

    更新日期：2008-05-01 00:00:00

  • Characterization of a d-tagatose 3-epimerase from Caballeronia fortuita and its application in rare sugar production.

    abstract：:Recently, rare sugars have caused extensively attention due to their beneficial physiological functions and potential applications in food systems and medical fields. Ketose 3-epimerase (KEase) can catalyze reversibly the epimerization between ketoses which is the pivotal enzyme in Izumoring strategy and an effective ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.07.112

    authors： Li S,Chen Z,Zhang W,Guang C,Mu W

    更新日期：2019-10-01 00:00:00

  • Preparation of semi-interpenetrating polymer networks composed of chitosan and poloxamer.

    abstract：:Through semi-interpenetration of polymer networks with poloxamer, mechanical properties of chitosan (CS) sponge were increased for wound dressing application. Synthesis of poloxamer macromer was confirmed by proton nuclear magnetic resonance (1H NMR) spectra. Possible interactions between CS and poloxamer in semi-inte...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2005.12.020

    authors： Kim IY,Yoo MK,Kim BC,Kim SK,Lee HC,Cho CS

    更新日期：2006-02-28 00:00:00

  • Cellulose extraction from methyltrioctylammonium chloride pretreated sugarcane bagasse and its application.

    abstract：:Cellulose, the most abundant feedstock of chemicals and energy is extracted from various agro-industrial wastes, such as sugarcane bagasse (SB). Pretreatment of SB with ionic liquids improves extraction of cellulose, yet the use of ionic liquid is hindered by its high cost. In this study, cellulose was extracted from ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.09.151

    authors： Ejaz U,Muhammad S,Ali FI,Hashmi IA,Sohail M

    更新日期：2020-12-15 00:00:00

  • Chemical modification of cellulosic biopolymer and its use in removal of heavy metal ions from wastewater.

    abstract：:Use of biological macromolecules for wastewater remediation process has become the topic of intense research mostly driven by growing concerns about the depletion of petroleum oil reserves and environmental problems. So in view of technological significance of cellulosic biopolymers in various fields, the present stud...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.03.046

    authors： Singha AS,Guleria A

    更新日期：2014-06-01 00:00:00

  • Machaerium acutifolium lectin alters membrane structure and induces ROS production in Candida parapsilosis.

    abstract：:Lectins are a group of widely distributed and structurally heterogeneous proteins of nonimmune origin. These proteins have the ability to interact with glycans present on cell surfaces and elicit diverse biological activities. Machaerium acutifolium lectin (MaL) is an N-acetyl-D-glucosamine-binding lectin that exhibit...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.06.236

    authors： Dias LP,Santos ALE,Araújo NMS,Silva RRS,Santos MHC,Roma RR,Rocha BAM,Oliveira JTA,Teixeira CS

    更新日期：2020-11-15 00:00:00

  • Insecticidal fungal metabolites fabricated chitosan nanocomposite (IM-CNC) preparation for the enhanced larvicidal activity - An effective strategy for green pesticide against economic important insect pests.

    abstract：:In the present study, enhanced pesticidal activity and biocompatibility of chitosan nanocomposite prepared with biocompatible polymer chitosan - insecticidal metabolites derived from potential fungal biopesticidal agent Nomuraea rileyi were studied. Insecticidal metabolites were isolated from the culture filtrate of f...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.08.130

    authors： Karthick Raja Namasivayam S,Arvind Bharani RS,Karunamoorthy K

    更新日期：2018-12-01 00:00:00

  • Probing the structure-function relationship of Mycobacterium leprae HSP18 under different UV radiations.

    abstract：:Ultraviolet radiation, an effective sterilizing source, rapidly kills the causative organism (Mycobacterium leprae) of leprosy. But, the reasons behind this quick death are not clearly understood. Also, the impact of UV radiation on the antigen(s) which is/are responsible for the survival of this pathogen is still unk...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.07.151

    authors： Chakraborty A,Nandi SK,Panda AK,Mahapatra PP,Giri S,Biswas A

    更新日期：2018-11-01 00:00:00

  • Bacterial cellulose in biomedical applications: A review.

    abstract：:Bacterial cellulose (BC) derived materials represents major advances to the current regenerative and diagnostic medicine. BC is a highly pure, biocompatible and versatile material that can be utilized in several applications - individually or in the combination with different components (e.g. biopolymers and nanoparti...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2017.05.171

    authors： Picheth GF,Pirich CL,Sierakowski MR,Woehl MA,Sakakibara CN,de Souza CF,Martin AA,da Silva R,de Freitas RA

    更新日期：2017-11-01 00:00:00

  • Synthesis, optimization and characterization of acetylated corn starch with the high degree of substitution.

    abstract：:Acetylated corn starch (ACS) was synthesized by the reaction of native corn starch (NCS) with acetic anhydride (AA) and acetic acid in an aqueous medium in the presence of p-toluenesulfonic acid (PTSA) as a catalyst. The factors that could affect the degree of substitution (DS) of corn starch were investigated which i...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.04.080

    authors： Han F,Gao C,Liu M,Huang F,Zhang B

    更新日期：2013-08-01 00:00:00

  • Anti-tumor and macrophage activation induced by alkali-extracted polysaccharide from Pleurotus ostreatus.

    abstract：:Pleurotus ostreatus is popularly consumed as traditional medicine and health food for enhancing immune function in China. Polysaccharides from mushroom have been demonstrated to possess a wide range of health beneficial properties. This study was carried out to elucidate the immunomodulating effects and molecular mech...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.05.045

    authors： Kong F,Li FE,He Z,Jiang Y,Hao R,Sun X,Tong H

    更新日期：2014-08-01 00:00:00

  • Extraction, characterization and in vitro antioxidant activity of polysaccharides from Carex meyeriana Kunth using different methods.

    abstract：:Response surface methodology (RSM) combined with a Box-Behnken design (BBD) was used to optimize the hot-water extraction (HWE) conditions which were determined to be: liquid-solid ratio 29.25:1 mL/g, extraction time 1.66 h, extraction temperature 95 °C, the optimized yield of polysaccharides 0.47 ± 0.01% (n = 3). Hot...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.09.125

    authors： Hu Z,Wang P,Zhou H,Li Y

    更新日期：2018-12-01 00:00:00

  • Chitosan-alginate immobilized lipase based catalytic constructs: Development, characterization and potential applications.

    abstract：:In this study, lipase (LIP) was isolated from Aspergillus crevinus, statistically optimized and purified via ammonium sulfate fractionation (ASF), and Sephadex G-100 gel permeation chromatography. LIP was 2.26-folds purified with a specific activity of 223.60 U/mg. The molecular mass was estimated to be 60 kDa on sodi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.07.192

    authors： Rashid R,Anwar Z,Zafar M,Rashid T,Butt I

    更新日期：2018-11-01 00:00:00

  • Development and characterization of a novel GHR antibody antagonist, GF185.

    abstract：:Here, we describe the development of a panel of monoclonal antibodies targeting the growth hormone receptor (GHR). Of these monoclonal antibodies (Mabs), GF185 was selected for further characterization due to its activities. Competitive receptor-binding assays and Western blotting analyses were used to demonstrate tha...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.05.039

    authors： Sun F,Liu Y,Sun H,Tian B

    更新日期：2015-08-01 00:00:00

  • Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides.

    abstract：:Hericium erinaceus polysaccharide (HEP) is a traditional Chinese medicine. In the present study, chemical composition and antioxidant activity of HEP was investigated. HPLC analysis showed that the HEP was composed of xylose (7.8%), ribose (2.7%), glucose (68.4%), arabinose (11.3%), galactose (2.5%) and mannose (5.2%)...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.09.009

    authors： Han ZH,Ye JM,Wang GF

    更新日期：2013-01-01 00:00:00

  • Poly(vinyl chloride) blend with biodegradable cellulose acetate in presence of N-(phenyl amino) maleimides.

    abstract：:Wider plastic applications of poly(vinyl chloride) (PVC) has raised serious problem to the environment. Since (PVC) waste products resist biodegradation and persist in the environment for longer time. The object of this study is to blend (PVC) with biodegradable cellulose acetate to thermally support the polymer durin...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.06.033

    authors： Abdel-Naby AS,Al-Ghamdi AA

    更新日期：2014-09-01 00:00:00

  • Biosynthesis and characterization of polyhydroxyalkanoates by Pseudomonas guezennei from alkanoates and glucose.

    abstract：:The biosynthesis of medium chain length poly(3-hydroxyalkanoates) mcl PHAs by Pseudomonas guezennei using glucose, sodium octanoate, and 10-undecenoic acid as sole or mixed carbon sources was investigated. Chemical composition of polyesters was analyzed by GCMS and NMR. The copolyester produced by P. guezennei from gl...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.08.018

    authors： Simon-Colin C,Gouin C,Lemechko P,Schmitt S,Senant A,Kervarec N,Guezennec J

    更新日期：2012-12-01 00:00:00

  • Synthesis and characterization of carboxymethyl starch-g-polyacrylic acids and their properties as adsorbents for ammonia and phenol.

    abstract：:Cigarette smoke contains a lot of harmful chemicals which cause different diseases like cancer, heart disease, bronchitis and ulcer etc. Ammonia and phenol are among those chemicals which cause cancer, fibrosis, respiratory disorder and pneumonia. So, to remove ammonia and phenol from cigarette smoke, five different t...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.07.046

    authors： Haroon M,Yu H,Wang L,Ullah RS,Haq F,Teng L

    更新日期：2019-10-01 00:00:00

  • Doxorubicin-loaded fucoidan capped gold nanoparticles for drug delivery and photoacoustic imaging.

    abstract：:Polymer nanoparticles are emerging as a useful tool for a wide variety of biomedical and therapeutic applications. The present study demonstrates the multifunctional doxorubicin-loaded fucoidan capped gold nanoparticles (DOX-Fu AuNPs) for drug delivery and photoacoustic imaging (PAI). Biocompatible AuNPs were synthesi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.06.007

    authors： Manivasagan P,Bharathiraja S,Bui NQ,Jang B,Oh YO,Lim IG,Oh J

    更新日期：2016-10-01 00:00:00

  • Synthesis of anionic chitosan surfactant and application in silver nanoparticles preparation and corrosion inhibition of steel.

    abstract：:Three anionic chitosan surfactant with different hydrophobic tails labeled Chitosan-R8, Chitosan-R12 and Chitosan-R16 were prepared and their surface behavior in aqueous solution was determined by surface tension measurements at three different temperatures 20, 40 and 60 °C. The affinity of the synthesized anionic chi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.184

    authors： Badr EA,Hefni HHH,Shafek SH,Shaban SM

    更新日期：2020-08-15 00:00:00

  • Antitumor and antimetastatic activities of rhamnogalacturonan-II-type polysaccharide isolated from mature leaves of green tea via activation of macrophages and natural killer cells.

    abstract：:To investigate the antitumor and antimetastatic polysaccharide from the mature leaves of green tea, GTE-II was purified using size exclusion chromatography. GTE-II consisted of 15 different sugars including rarely observed sugars such as 2-O-methyl-fucose, 2-O-methyl-xylose, apiose, aceric acid, 3-deoxy-d-manno-2-octu...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.02.043

    authors： Park HR,Hwang D,Suh HJ,Yu KW,Kim TY,Shin KS

    更新日期：2017-06-01 00:00:00

  • Molecular masses and sedimentation coefficients of extracellular hemoglobin of Glossoscolex paulistus: alkaline oligomeric dissociation.

    abstract：:The giant extracellular hemoglobin of Glossoscolex paulistus (HbGp) has a molecular mass (M) of 3600±100 kDa and a standard sedimentation coefficient (s20,w0) of 58 S, estimated by analytical ultracentrifugation (AUC). In the present work, further AUC studies were developed for HbGp, at pH 10.0, which favors oligomeri...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2010.11.002

    authors： Carvalho FA,Santiago PS,Borges JC,Tabak M

    更新日期：2011-01-01 00:00:00

  • Deep eutectic solvents as simultaneous plasticizing and crosslinking agents for starch.

    abstract：:The aim of this work was to prepare deep eutectic solvents (DES) made with choline salts with α-hydroxylate anions and glycerol and apply them as starch plasticizers. Additionally, crosslinking potential of polyfunctional anions from the salts was investigated. Starch/DES premixtures were rheologically and thermally (...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.02.103

    authors： Zdanowicz M,Jędrzejewski R,Pilawka R

    更新日期：2019-05-15 00:00:00

  • Conformational features of galacturonans. II. Configurational statistics of pectic polymers.

    abstract：:The unperturbed dimensions of poly-alpha-D-galacturonic acid (PGA) as a function of the degree of polymerization (n) and degree of ionization (%GalA-) have been determined by molecular mechanics and Monte Carlo methods. Chain extensions appear to depend substantially on contributions arising from local redistributions...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/0141-8130(95)92688-m

    authors： Ruggiero JR,Urbani R,Cesàro A

    更新日期：1995-06-01 00:00:00

  • Preparation of low digestible and viscoelastic tigernut (Cyperus esculentus) starch by Bacillus acidopullulyticus pullulanase.

    abstract：:Tigernut starch is an underutilized food resource. In this study, pullulanase (PUL) hydrolysis was used to change its physiochemical properties for different food applications. The content of low digestible fractions, resistant starch and slow digestible starch, in PUL modified tigernut starch significantly increased ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.04.068

    authors： Li X,Fu J,Wang Y,Ma F,Li D

    更新日期：2017-09-01 00:00:00

  • Dual responsive aerogel made from thermo/pH sensitive graft copolymer alginate-g-P(NIPAM-co-NHMAM) for drug controlled release.

    abstract：:Alginate was grafted with NIPAM and NHMAM successfully, and a new responsive copolymer, alginate-g-P(NIPAM-co-NHMAM), was obtained. A novel dual responsive polysaccharide-based aerogel with thermo/pH sensitive properties was designed from the copolymer as drug controlled release system. The chemical structure of the c...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.03.166

    authors： Shao L,Cao Y,Li Z,Hu W,Li S,Lu L

    更新日期：2018-07-15 00:00:00

  • Knockdown of long non-coding RNA XIST inhibits cell viability and invasion by regulating miR-137/PXN axis in non-small cell lung cancer.

    abstract：:Long non-coding RNAs (lncRNAs) may serve as miRNA sponges to modulate the expressions of miRNA target genes. LncRNA X-inactive specific transcript (XIST) has been demonstrated to be upregulated and act as an oncogene in non-small cell lung cancer (NSCLC). However, the sponge role of XIST in NSCLC progression remains l...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.01.022

    authors： Jiang H,Zhang H,Hu X,Li W

    更新日期：2018-05-01 00:00:00

  • Novel transglycosylation activity of β-N-acetylglucosaminidase of Lecanicillium lecanii produced by submerged culture.

    abstract：:N-acetylglucosaminidase produced from Lecanicillium lecanii on submerged culture displayed hydrolytic and transglycosylation activities. The highest specific activity for the enzyme was 1.87 U/mg after 120 h of culture. The chromatographic purification for a single protein fraction showed a molecular weight of 50.4 kD...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.12.237

    authors： Rojas-Osnaya J,Rocha-Pino Z,Nájera H,González-Márquez H,Shirai K

    更新日期：2020-02-15 00:00:00

  • Comparative study of performances of lipase immobilized asymmetric polysulfone and polyether sulfone membranes in olive oil hydrolysis.

    abstract：:In the present study, lipase was immobilized via glutaraldehyde crosslinking on the polysulfone and polyether sulfone asymmetric membranes. The results indicated that the overall immobilization of lipase is related to the hydrophobicity of the membrane material and thus higher immobilization is achieved for polysulfon...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2007.10.018

    authors： Gupta S,Yogesh,Javiya S,Bhambi M,Pundir CS,Singh K,Bhattacharya A

    更新日期：2008-03-01 00:00:00