Abstract:
PURPOSE:To compare the rates of retinal nerve fiber layer (RNFL) thickness loss using optical coherence tomography (OCT) in progressing versus nonprogressing eyes using 4 methods to define functional progression. METHODS:Normal and glaucomatous eyes with ≥3 years of follow up were prospectively enrolled. Standard automated perimetry (Swedish Interactive Threshold Algorithm Standard 24-2) and OCT (Stratus OCT, Carl Zeiss Meditec, Dublin, CA) imaging were performed every 6 months in glaucomatous eyes. OCT imaging was performed annually in normal eyes. Functional progression was determined using early manifest glaucoma trial criterion, visual field index (VFI), Progressor software, and the 3-omitting method. RESULTS:Seventy-six eyes (46 glaucoma and 30 normal) of 38 patients were enrolled with a mean follow-up of 43.9 ± 5.02 months (range: 36 to 48 mo). Eleven eyes progressed using Progressor criterion, 5 eyes using VFI, 2 eyes using the 3-omitting method, and 2 eyes using Early Manifest Glaucoma Trial criterion. The annual rate of average RNFL loss (μm/y) was significantly greater (P<0.05) in progressing versus nonprogressing eyes using Progressor (-1.0 ± 1.3 vs. 0.02 ± 1.6), VFI (-2.1 ± 1.1 vs. -0.002 ± 1.4), and the 3-omitting method (-2.2 ± 0.2 vs. -0.1 ± 1.5). Mean rate (μm/y) of average and superior RNFL thickness change was similar (P>0.05) in nonprogressing glaucomatous eyes compared with normal eyes. Using linear mixed-effect models, mean (P<0.001) and peak (P=0.01) intraocular pressure were significantly associated with rate of average RNFL atrophy in glaucomatous eyes. CONCLUSIONS:Despite differences in criteria used to judge functional progression, eyes with standard automated perimetry progression have significantly greater rates of RNFL loss measured using OCT compared with nonprogressing eyes.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Grewal DS,Sehi M,Paauw JD,Greenfield DS,Advanced Imaging in Glaucoma Study Group.doi
10.1097/IJG.0b013e3182071cc7subject
Has Abstractpub_date
2012-04-01 00:00:00pages
214-20issue
4eissn
1057-0829issn
1536-481Xjournal_volume
21pub_type
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journal_title:Journal of glaucoma
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journal_title:Journal of glaucoma
pub_type: 杂志文章
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更新日期:1997-10-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2006-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章
doi:10.1097/00061198-200010000-00007
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journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1995-08-01 00:00:00
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更新日期:2003-10-01 00:00:00
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更新日期:2021-01-01 00:00:00
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更新日期:2007-03-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2020-07-01 00:00:00
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更新日期:2013-02-01 00:00:00
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更新日期:2018-06-01 00:00:00
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