Abstract：
:Due to the disadvantages of human and equine rabies immunoglobulin, it is necessary to develop a substitute for HRIG and ERIG, especially for those people living in the developing countries. Because of higher affinity and lower immunogenicity of rabbit's immunoglobulins, anti-rabies immunoglobulins specific to rabies virus were produced in rabbits as a bioreactor, and had been characterized by ELISA, affinity assay, immunofluorescence assay (IFA), immunocytochemistry, rapid fluorescent focus inhibition test (RFFIT). ELISA, affinity assay and IFA showed that rabbit RIG (RRIG) bound specifically to rabies virions. RFFIT result showed that RRIG has neutralization activity. This result was confirmed in vivo in a Kunming mouse challenge model and the protection rate of the treatment with RRIG was higher (25%) than that offered by HRIG when mice were challenged with a lethal RV dose. Our results demonstrate that RRIG is safe and efficacious as a candidate drug to replace rabies immunoglobulin in post-exposure prophylaxis.
journal_name
Trop Biomedjournal_title
Tropical biomedicineauthors
Liu X,Liu Q,Feng X,Tang Q,Wang Z,Li S,Feng Z,Zhu J,Guan Xsubject
Has Abstractpub_date
2011-04-01 00:00:00pages
138-48issue
1eissn
0127-5720issn
2521-9855journal_volume
28pub_type
杂志文章abstract：:We report a patient presenting with chronic diarrhoea of unidentified etiology. Laboratory results showed microcytic anemia, peripheral eosinophilia with negative results of stool sample smears and stool concentration technique. Ancylostoma duodenale was found in the caecum and terminal ileum during colonoscopy. The p...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2014-03-01 00:00:00
abstract：:Understanding the genetic diversity, extent and distribution of variant forms of Plasmodium vivax parasites is crucial in the development of effective control measures and in Orissa, a hyperendemic state in the eastern part of India, the polymorphic nature of P. vivax isolates is largely lacking. The result of the stu...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2010-12-01 00:00:00
abstract：:Dengue virus (DV) infections are a serious public health problem and there is currently no vaccine or drug treatment. NS2B/NS3 protease, an essential enzyme for viral replication, is one of the promising targets in the search for drugs against DV. In this research work, virtual screening (VS) was carried out on four m...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2013-09-01 00:00:00
abstract：:This study was conducted to determine the prevalence of intestinal parasites among children and adult Orang Aslis (Aborigines) from different locations in Perak. Faecal samples were collected and analyzed using the direct smear and formal ether sedimentation technique. Some of the faecal samples were stained usi...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2012-06-01 00:00:00
abstract：:Plasmodim vivax malaria accounts for more than 90% of malaria cases in Sri Lanka. There is limited information on the genetic heterogeneity of P. vivax in endemic areas of the country. Here we have assessed the potential of two P. vivax genes as genetic markers for their use in genotyping parasites collected from the ...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2008-08-01 00:00:00
abstract：:A total of 29 female black flies were captured by a hand net as they swarmed around humans in Tam Dao National Park, Vinh Phuc Province, Vietnam. They included one species of the subgenus Gomphostilbia (Simulium (Gomphostilbia) asakoae Takaoka & Davies) and five species of the subgenus Simulium, of which one species i...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2014-12-01 00:00:00
abstract：:The majority of amoeba infection are asymptomatic, but clinically intestinal amoebiasis or extra intestinal amoebiasis may result. Genital amoebiasis is very rare manifestation of extra intestial amoebiasis, but a case of amoebic scrotal abscess, seen in Surabaya. The invasive form of Entamoeba histolytica trophozoite...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2015-09-01 00:00:00
abstract：:This paper reports an outbreak of trypanosomiasis due to Trypanosoma evansi in Java deer (Cervus timorensis) on a government deer farm in Lenggong, Perak. Seventeen adult female Java deer were found dead within a week. Symptoms of dullness, inappetence, anaemia, anorexia, respiratory distress and recumbency were seen ...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2007-12-01 00:00:00
abstract：:This study explored the efficacy of Toxorhynchites splendens, predator of Aedes albopictus as a biocontrol agent. There was a negative correlation between Ae. albopictus larval population and Tx. splendens larval population in ovitraps (r=-0.287, R²=0.0821). The correlation is higher between the mean number of Ae. alb...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2011-08-01 00:00:00
abstract：:Analysis on fly artifacts produced by forensically important blowfly, Chrysomya megacephala (Fabricius) (Diptera:Calliphoridae), revealed several unique patterns. They can be divided into fecal spots, regurgitation spots and swiping stains. The characteristics of fecal spots are round with three distinct levels of pig...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2008-04-01 00:00:00
abstract：:This paper discusses the colonization of the stratiomyid species Ptecticus melanurus (Walker) (Diptera: Stratiomyidae) in monkey carrion and its potential for the determination of the minimum time since death (PMI). A study was conducted in a tropical forest at Bangi, Malaysia from 13 November 2009 to 8 June 201...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：:Dengue serotype surveillance is important as any changes in serotype distribution may result in an outbreak or increase in severe dengue cases. This study aimed to determine circulating dengue serotypes in two hospitals in Selangor. Serum samples were collected from patients admitted for dengue at these two major publ...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2015-03-01 00:00:00
abstract：:Entamoeba histolytica causes amoebic diarrhoea, colitis and liver abscess (ALA). Diagnosis of ALA is difficult, as most patients do not have simultaneous intestinal amoebic infection. At Hospital Universiti Sains Malaysia (HUSM), diagnosis of ALA relies on a combination of clinical findings, ultrasound examination of ...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2013-06-01 00:00:00
abstract：:In this case series report we aim to report a Disseminated Intravascular Coagulation (DIC)-like syndrome associated with Hemiscorpius lepturus sting in 4 individuals and a novel management protocol for this life-threatening condition that comprised partial exchange transfusion in severe scorpionism. ...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：:In this study, 13 weeks (October to December 2012) of ovitrap surveillance was conducted in two suburban residential areas in Kampar town, Perak. A total of 17,310 Aedes mosquitoes were found in Taman Kampar Jaya, whereas Taman Juloong recorded a higher number at 19,042. Less than 1% of these were identified as Aedes ...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2014-09-01 00:00:00
abstract：:One hundred and sixty eight rats were trapped from the National Service Training Centres (NSTC) in Kelantan and Terengganu from October 2008 to May 2009. Microscopic agglutination test (MAT) was performed to detect the presence of agglutinating antibodies to Leptospira among the rats caught. All the MAT positive rats ...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2010-04-01 00:00:00
abstract：:A cohort study was performed to evaluate the incidence and risk factors of Giardia duodenalis infection in an orphanage in suburban area outside Bangkok, central Thailand. Stool specimens were examined for the presence of G. duodenalis in January 2007, May 2007 and January 2008. Of 892 stool specimens from 481 individ...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2014-09-01 00:00:00
abstract：:Scanning electron microscope (SEM) images of two dust mites, Sturnophagoides brasiliensis and Sturnophagoides halterophilus, are presented to provide an improved visualization of the taxonomic characters of these mites. Sturnophagoides halterophilus can be differentiated from S. brasiliensis by their expanded genu and...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2008-12-01 00:00:00
abstract：:Sugarcane bagasse is a renewable resource that can be used to produce biopesticide for the control of mosquito vectors. In the present study, we demonstrated that cane processed bagasse could be used to produce Bacillus thuringiensis serovar israelensis (Bti) for control of mosquito vectors viz: Culex quinquefasciatus...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2013-09-01 00:00:00
abstract：:Japanese encephalitis (JE) virus activity is an important cause of viral encephalitis in Southeast Asia. In Malaysia, JEV activity has been first detected in Culex gelidus in 1976. Since then, no study has fully addressed the seasonal dynamics of this mosquito. As irrigated rice production expands, the incidence of JE...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2010-12-01 00:00:00
abstract：:Changes in the abundance of the house fly, Musca domestica, was studied for a period of one year in two poultry farms in Penang, Malaysia: one in Balik Pulau, located in Penang island, and the other in Juru, located on mainland Penang. The sampling of house flies were carried out from March 2007 to April 2008 using th...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2009-08-01 00:00:00
abstract：:Toxoplasmosis can cause serious disease in immunocompromised patients and to congenitally infected foetuses. Appropriate laboratory investigations in potential cases of acute Toxoplasma infection are important. Excretory secretory antigen (ESA) is immunogenic during both human and experimental infections, theref...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：:Field bioefficacy of residual-sprayed deltamethrin against Aedes vectors was evaluated in an urban residential area in Kuala Lumpur. The trial area consisted of single storey wood-brick houses and a block of flat. The houses were treated with outdoor residual spraying while the flat was used as an untreated control. I...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2005-12-01 00:00:00
abstract：:Crab is an important source of food allergen. Tropomyosin represents the main crab allergen and is responsible for IgE cross-reactivity between various species of crustaceans. Recently, other new crab allergens including arginine kinase have been identified. However, information on allergens of the local Portuni...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
abstract：:Signal fly, Scholastes sp. (Diptera: Platystomatidae) was observed associated with animal carcasses in Malaysia. The first observation was on a monkey carcass, which was killed by using a handgun and immediately placed in a forested area in Gombak, Selangor while the second observation was on a pig that died of natura...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2008-12-01 00:00:00
abstract：:Haematophagous dipterans belonging to 10 genera - Aedes (12), Anopheles (14), Armigeres (01), Culex (09), Toxorhynchites (01), Uranotaenia (01), Sergentomyia (02), Phlebotomus (01), Atylotus (01) and Tabanus (03) were encountered from 12 localities under 6 blocks of Dehradun district (Uttarakhand) during January 2011 ...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2013-12-01 00:00:00
abstract：:A focal outbreak of malaria at Sialimal sub-centre of Balasore district of Orissa was reported during the month of March, 2010. Three villages of the above block were affected. Regional Medical Research Centre, Bhubaneswar has conducted an entomological survey and a central clinic simultaneously, with door to do...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2012-06-01 00:00:00
abstract：:A survey of cockroach fauna was carried out on the 3 inhabited islands of the Ogasawara chain island of Japan, namely, Chichijima island, Hahajima island and Iwo island. Seven species, namely, Periplaneta americana (Linnaeus, 1758), Periplaneta australasiae (Fabricius, 1775), Blattella lituricollis (Walker, 1868), Ony...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:The adulticidal activity of methanol extracts from three Malaysian plants namely Acorus calamus Linn., Litsea elliptica Blume and Piper aduncum Linn. against adult of Aedes aegypti (L.) were studied. Standard WHO bioassay tests were used to evaluate the effectiveness of these plant extracts. The hexane fraction from m...
journal_title：Tropical biomedicine
pub_type： 杂志文章
doi：
更新日期：2004-12-01 00:00:00
abstract：:Entamoeba histolytica, the causative agent of human amoebiasis remains a significant cause of morbidity and mortality in developing countries and is responsible for up to 100,000 deaths worldwide each year. Entamoeba dispar, morphologically indistinguishable from E. histolytica is more common in humans in many parts o...
journal_title：Tropical biomedicine
pub_type： 杂志文章,评审
doi：
更新日期：2011-08-01 00:00:00
