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The FALC-Loop web server for protein loop modeling.

Abstract：

:The FALC-Loop web server provides an online interface for protein loop modeling by employing an ab initio loop modeling method called FALC (fragment assembly and analytical loop closure). The server may be used to construct loop regions in homology modeling, to refine unreliable loop regions in experimental structures or to model segments of designed sequences. The FALC method is computationally less expensive than typical ab initio methods because the conformational search space is effectively reduced by the use of fragments derived from a structure database. The analytical loop closure algorithm allows efficient search for loop conformations that fit into the protein framework starting from the fragment-assembled structures. The FALC method shows prediction accuracy comparable to other state-of-the-art loop modeling methods. Top-ranked model structures can be visualized on the web server, and an ensemble of loop structures can be downloaded for further analysis. The web server can be freely accessed at http://falc-loop.seoklab.org/.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Ko J,Lee D,Park H,Coutsias EA,Lee J,Seok C

doi

10.1093/nar/gkr352

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

W210-4

issue

Web Server issue

eissn

0305-1048

issn

1362-4962

pii

gkr352

journal_volume

39

pub_type

杂志文章

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