Abstract:
:The expression of mucinous ovarian cancer (OVC) antigen by hybrid cell lines derived by fusing a malignantly transformed Bloom syndrome (BS) cell line (BS-SHI-4M OVC-MU) and mouse L cells has been studied. Cell surfaces of 16 hybrids which grew 12-40 days post-fusion have been analysed by using a number of sera from mucinous OVC patients and indirect membrane immunofluorescence (IF). Three hybrids which appeared at a late stage (30-40 days in 24-well culture plates) were clearly positive in almost 100% of the hybrid cell population, while all of those which appeared earlier (in 12 days) were completely negative. Cytogenetic analysis showed that these three hybrids with positive mucinous OVC antigen contained human chromosome 22 or 22q-, though no metaphases from antigen negative population had 22 or 22q-. Therefore, we assign the gene for mucinous OVC antigen to the chromosome 22. Identification of chromosome 22 in hybrid cells was confirmed by the fluorescence in situ hybridization (FISH) analysis using chromosome 22 painting probe.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Shiraishi Y,Taguchi T,Seguchi Hdoi
10.3892/ijo.7.6.1275subject
Has Abstractpub_date
1995-12-01 00:00:00pages
1275-8issue
6eissn
1019-6439issn
1791-2423journal_volume
7pub_type
杂志文章abstract::Overexpression of inducible nitric oxide synthase (iNOS) and the resultant overproduction of NO has been implicated in neuronal inflammatory diseases. Leptomycin B (LMB), a metabolite of Streptomyces, has been identified as a specific inhibitor of CRM1 nuclear export receptor. In this study, we evaluated the effect of...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2006-12-01 00:00:00
abstract::Release of DNA fragments into the culture supernatant of human promyelocytic cell line HL-60 was investigated. The released DNA has previously been shown to have a strong immunosuppressive effect on the proliferation of mitogen-stimulated human peripheral lymphocytes and some cancer cell lines. In this study, HL-60 ce...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.2.417
更新日期:1994-02-01 00:00:00
abstract::The mutation of isocitrate dehydrogenase (IDH)1 (R132H) and IDH2 (R172K) and the induction of hypoxia in various solid tumors results in alterations in metabolic profiles, including the production of the d‑ or l‑forms of 2‑hydroxyglutarate (2HG) from α‑ketoglutarate in aerobic metabolism in the tricarboxylic acid (TCA...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4649
更新日期:2019-02-01 00:00:00
abstract::Lung cancer is one of the most common types of cancer worldwide. Understanding the molecular mechanisms underlying the development and progression of lung cancer may improve early diagnosis, treatment and prognosis. The aim of the present study was to examine the pathogenesis of lung cancer and to identify potentially...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4926
更新日期:2020-01-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
abstract::Secondary metabolites from actinomycetes especially the genus Streptomyces may be one of the most important sources for novel anticancer agents. A purified fraction from a novel actinomycete strain, Streptomyces sp. H7372, was elucidated in breast cancer cells. We have isolated three purified fractions from a novel st...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000774
更新日期:2010-11-01 00:00:00
abstract::Following the publication of this article, the authors noted that there was an error in the affiliations. Specifically, the affiliation of the first author JUAN XU should be: Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang 321000, P.R. China. [the original article was publis...
journal_title:International journal of oncology
pub_type: 杂志文章,已发布勘误
doi:10.3892/ijo.2017.3977
更新日期:2017-06-01 00:00:00
abstract::The overall goal of the present study was to evaluate the chemotherapeutic and cancer‑protective properties of D‑erythro‑sphingosine (sphingosine) and C2‑ceramide using a human breast epithelial cell (HBEC) culture system, which represents multiple‑stages of breast carcinogenesis. The HBEC model includes Type I HBECs ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4641
更新日期:2019-02-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2015.3306
更新日期:2016-03-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3536
更新日期:2016-08-01 00:00:00
abstract::The molecular basis of host-tumor interaction in HLA-A31+ cancer patients has not been well understood. This lack of clarification is hampering the development of specific immunotherapies for these patients. This study aimed to identify a set of CTL-epitope peptides applicable for the specific immunotherapy of cancer ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-02-01 00:00:00
abstract::Myofibroblasts in the stroma of pancreatic cancers promote tumor proliferation, invasion and metastasis by increasing extracellular matrix and secretion of several growth factors. In contrast, the role of myofibroblasts at peritoneally disseminated sites of pancreatic cancer has not yet been determined. This study was...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2391
更新日期:2014-07-01 00:00:00
abstract::Peripheral blood mononulear cells (PBMC) derived from 10 asymptomatic human T lymphotropic virus type I (HTLV-I) carriers were cultured for a short term (10-14 days) in the absence of exogenous antigens. In 5 carriers, when compared with 5 HTLV-I non-carriers an apparent increase in the proportion of CD8+ DR+ cells wa...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.5.2.159
更新日期:1994-08-01 00:00:00
abstract::We have isolated a new -ene, named BAC, which is the human equivalent of the murine H19 gene and is highly expressed in most fetal tissues and in a variety of fresh tumors. BAC was analyzed in 130 untreated invasive carcinomas of different types. The frequency of BAC-expressing cancers as well as the level of expressi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2.5.753
更新日期:1993-05-01 00:00:00
abstract::In a previous study, it was demonstrated that Rhein lysinate (RHL) inhibited HeLa cell proliferation via a specific mechanism. The aim of the present study was to clarify the mechanism of RHL by investigating its effect on mitochondrial damage and cell apoptosis. The results indicated that RHL inhibited cell growth an...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4554
更新日期:2018-11-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3796
更新日期:2017-02-01 00:00:00
abstract::NGFI-B, Nurr1 and NOR-1 have structural features of ligand-activated transcriptional regulators and constitute the NGFI-B subfamily within the nuclear receptor superfamily. Since specific ligands for these molecules have not yet been identified, they are often called orphan nuclear receptors. Genes of the NGFI-B subfa...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.12.6.1237
更新日期:1998-06-01 00:00:00
abstract::To clarify the relationship between angiogenesis and the early development of colon cancer, expression of platelet-derived endothelial cell growth factor (PD-ECGF), a known angiogenic and endothelial cell chemotactic factor, was examined in 119 human colon premalignant adenomas and colon carcinomas. Localization of PD...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.8.6.1105
更新日期:1996-06-01 00:00:00
abstract::Chronic administration of 17 beta-estradiol to male Syrian hamsters for at least six months induces estrogen-dependent kidney tumors, which express high levels of c-fos mRNA compared to surrounding renal or control tissues. We have investigated the cellular localization of c-Fos oncoprotein in these tissues and studie...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.7.3.527
更新日期:1995-09-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.3.567
更新日期:1994-03-01 00:00:00
abstract::We investigated the effect of stabilized Fab oligomerization by disuccinimidyl suberate on tumor uptake in a pancreatic carcinoma xenograft model in nude mice. Recombinant mouse/human chimeric Fab of the anti-carcinoembryonic antigen (CEA) monoclonal antibody A10, which was previously shown to react specifically with ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.14.1.139
更新日期:1999-01-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.4998
更新日期:2020-05-01 00:00:00
abstract::The aim of the present study was to evaluate the effects of programmed cell death 4 (PDCD4) on cell proliferation and apoptosis, and to elucidate the potential role of the Jun N-terminal kinase (JNK)/c-Jun pathway in human bladder cancer (BCa) cells. Mixed BCa cells were transfected with plasmids containing PDCD4 (PDC...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4303
更新日期:2018-05-01 00:00:00
abstract::Glycodelin [gene name, progesterone associated endometrial protein (PAEP)] was initially described as an immune system modulator in reproduction. Today, it is also known to be expressed in several types of cancer, including non‑small cell lung cancer (NSCLC). In this cancer type, the feasibility of its usage as a foll...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4654
更新日期:2019-02-01 00:00:00
abstract::The RON receptor tyrosine kinase and its ligand macrophage stimulating protein (MSP) play a role in epithelial tumorigenesis. We report here a novel RON variant that antagonizes the RON-MSP pathway in various cancer cells. The variant is an 85 kDa soluble protein from an mRNA transcript with an insertion of 49 nucleot...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000642
更新日期:2010-06-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.17.4.841
更新日期:2000-10-01 00:00:00
abstract::One of the genes that the authors have isolated by a differential display of hepatocellular carcinoma compared to adjacent liver is the alpha6 integrin. alpha6 integrin is the major adhesion receptor for laminin and is suggested to be involved in tumor cell invasion and metastasis. To our knowledge, however, there are...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.16.4.725
更新日期:2000-04-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2002-04-01 00:00:00
abstract::Developing simple and effective approaches to detect tumor markers will be critical for early diagnosis or prognostic evaluation of prostate cancer treatment. Prostate‑specific membrane antigen (PSMA) has been validated as an important tumor marker for prostate cancer progression including angiogenesis and metastasis....
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
abstract::Cholangiocarcinoma (CCA) is a lethal malignancy which occurs with relatively high incidence in Thailand. This cancer is often difficult to diagnose and associated with high mortality. The secretome, containing the secreted proteins from cells, are potentially useful as biomarkers of cancers. Since three-dimensional (3...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2636
更新日期:2014-11-01 00:00:00