Molecular X-ray computed tomography of myelin in a rat brain.

Abstract:

:In this work we demonstrate the feasibility of applying small-angle X-ray scattering computed tomography (SAXS-CT) for non-invasive molecular imaging of myelin sheaths in a rat brain. Our results show that the approach yields information on several quantities, including the relative myelin concentration, its periodicity, the total thickness of the myelin sheaths, and the relative concentration of cytoskeletal neurofilaments. For example the periodicity of the myelin sheaths varied in the range from 17.0 to 18.2 nm around an average of 17.6 (±0.3) nm. We believe that imaging, i.e., spatially resolved measuring these quantities could provide general means for understanding the relation to a number of neurodegenerative diseases.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Jensen TH,Bech M,Bunk O,Menzel A,Bouchet A,Le Duc G,Feidenhans'l R,Pfeiffer F

doi

10.1016/j.neuroimage.2011.04.013

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

124-129

issue

1

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(11)00391-0

journal_volume

57

pub_type

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