Abstract:
:In this work we demonstrate the feasibility of applying small-angle X-ray scattering computed tomography (SAXS-CT) for non-invasive molecular imaging of myelin sheaths in a rat brain. Our results show that the approach yields information on several quantities, including the relative myelin concentration, its periodicity, the total thickness of the myelin sheaths, and the relative concentration of cytoskeletal neurofilaments. For example the periodicity of the myelin sheaths varied in the range from 17.0 to 18.2 nm around an average of 17.6 (±0.3) nm. We believe that imaging, i.e., spatially resolved measuring these quantities could provide general means for understanding the relation to a number of neurodegenerative diseases.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Jensen TH,Bech M,Bunk O,Menzel A,Bouchet A,Le Duc G,Feidenhans'l R,Pfeiffer Fdoi
10.1016/j.neuroimage.2011.04.013subject
Has Abstractpub_date
2011-07-01 00:00:00pages
124-129issue
1eissn
1053-8119issn
1095-9572pii
S1053-8119(11)00391-0journal_volume
57pub_type
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