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Vasodilatory effect of hydroxyethyl methacrylate and triethylene glycol dimethacrylate in rat aorta through calcium antagonistic action.

Abstract：

INTRODUCTION:Resin-based dental materials contain various diluent monomers that can interfere with vascular function by causing vasodilation. In this study, we evaluated the vasoactive potential of hydroxyethyl methacrylate (HEMA) and triethylene glycol dimethacrylate (TEGDMA) and the possible mechanism of their vascular action on isolated rat aorta. METHODS:Responses of thoracic aorta rings were recorded isometrically by using force displacement transducers. After precontracting aorta rings with phenylephrine, relaxations to HEMA and TEGDMA were recorded in the absence and presence of nitric oxide synthase inhibitor N(ω)-nitro-L-arginine methyl ester, cyclooxygenase inhibitor indomethacin, and K(+) channel inhibitors tetraethylammonium, glibenclamide, and 4-aminopyridine. To investigate the Ca(2+)-channel antagonistic effect of HEMA and TEGDMA in different aorta rings, concentration-response curves to CaCl(2) were obtained in the absence and presence of the test monomers. RESULTS:Both HEMA and TEGDMA elicited concentration-dependent relaxations. The vasorelaxant effect of HEMA and TEGDMA was not mediated via endothelium-dependent nitric oxide and prostanoid-dependent mechanisms or by K(+) efflux through K(+) channels. Both monomers significantly inhibited the contractions induced by CaCl(2). CONCLUSIONS:Our results showed that HEMA and TEGDMA induce vasodilation via Ca(2+)-antagonistic action, whereas nitric oxide and cyclooxgenase pathway and K(+) channels were not responsible for this vasoactive effect.

journal_name

J Endod

journal_title

Journal of endodontics

authors

Guven G,Seyrek M,Vural IM,Cehreli ZC,Yildiz O

doi

10.1016/j.joen.2010.11.038

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

353-7

issue

3

eissn

0099-2399

issn

1878-3554

pii

S0099-2399(10)00981-7

journal_volume

37

pub_type

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