Abstract:
INTRODUCTION:The treatment of immature necrotic permanent teeth presents several clinical challenges in endodontics. Regenerative endodontic procedures (REPs) permit root development, increased canal wall thickness, and apical closure. This longitudinal cohort study aimed to evaluate the long-term clinical and radiographic outcomes of REPs of immature necrotic permanent teeth over a 30-month period. METHODS:This study was performed at the Division of Dentistry of the Montreal Children's Hospital, Montreal, Quebec, Canada. Twenty-eight immature necrotic permanent teeth from 22 patients were included in this study. All teeth were treated with a standardized REP protocol. Patients had follow-up appointments at 1, 2, 3, 6, 12, 18, 24, and 30 months. At each appointment, signs and symptoms were evaluated. Radiographic evaluation was also performed by a calibrated endodontist in order to analyze different parameters. RESULTS:Our results show a high survival rate (96.4%), clinical success (92.8%), and resolution of apical pathology (100%). Significant increases in the average root length (8.1%, P < .0001) and root thickness area (11.6%, P = .03) were observed after 30 months. In the study period, a significant decrease in the apical diameter was also noted, with 30.8% of the cases showing complete apical closure. Teeth with more immature stages of root development had a higher percentage of change in root thickness, length, and apical diameter; however, these results were not statistically significant. CONCLUSIONS:Teeth treated with REPs presented resolution of symptoms. Although clinical meaningful change was not achieved in all cases, increased root thickness, root length, and apical closure were observed at 30 months.
journal_name
J Endodjournal_title
Journal of endodonticsauthors
Chan EK,Desmeules M,Cielecki M,Dabbagh B,Ferraz Dos Santos Bdoi
10.1016/j.joen.2016.10.035subject
Has Abstractpub_date
2017-03-01 00:00:00pages
395-400issue
3eissn
0099-2399issn
1878-3554pii
S0099-2399(16)30798-1journal_volume
43pub_type
杂志文章abstract:INTRODUCTION:A major complication after endodontic treatment is persistent pain on biting or chewing. Although unsuccessful endodontic treatment can account for such pain, pain to chewing and biting can also be a result of an unsupported or propagated crown fracture. Crown fractures that extend apically result in deter...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2014.06.021
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:During apicoectomy and retrograde cavity preparation, a smear layer, which contains microorganisms and necrotic pulpal tissues, is formed on the dentinal surfaces cut by the instruments. Bacteria can survive and proliferate inside or below the smear layer. The purpose of this study was to evaluate in vitro...
journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2011.03.001
更新日期:2011-06-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to evaluate the fracture strength of roots instrumented with the Self-Adjusting File (SAF; ReDent-Nova, Ra'anana, Israel) and the ProTaper system (Dentsply Maillefer, Ballaigues, Switzerland) and filled with the cold lateral compaction technique. METHODS:In total, 50 mandibul...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.08.030
更新日期:2014-04-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to evaluate the effect of a range of alkaline pH values on the push-out strength of white mineral trioxide aggregate (WMTA). METHODS:The standardized lumens of root slices prepared from extracted single-rooted human teeth were filled with white ProRoot MTA. The specimens were the...
journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2010.08.022
更新日期:2010-11-01 00:00:00
abstract::Studies of endodontic outcomes suggest that fracture of the tooth after endodontic therapy may be a greater problem than endodontic reinfection. Immediate full coverage with or without a post and core is the best way to prevent fracture. Unfortunately, in many population areas, due predominantly to cost, this restorat...
journal_title:Journal of endodontics
pub_type: 杂志文章,评审
doi:10.1016/j.joen.2019.12.012
更新日期:2020-04-01 00:00:00
abstract::The occurrence of Enterococcus faecalis in root canals of previously root filled teeth with apical periodontitis requiring retreatment was studied in Lithuanian patients. Twenty-five asymptomatic teeth were included in the study. Avoiding contamination microbiological samples were taken from the canals before and afte...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200010000-00004
更新日期:2000-10-01 00:00:00
abstract::The cross-sectional configuration of seven files at coronal and apical levels were compared with diagrams presented by manufacturers. The presence of cutting edges was also examined. Ground-twisted (K-file, K-Reamer, and K-flex) and machined files (Flex-R, Unifile, S-file, and Hedstrom) were included in #10, #25, and ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)81111-8
更新日期:1995-12-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to compare the fracture resistance of cast posts versus the fracture resistance of fiber posts by means of meta-analysis when they were used in the restoration of endodontically treated teeth. METHODS:MEDLINE, Cochrane Controlled Trials Register, China National Knowledge Infrastr...
journal_title:Journal of endodontics
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.joen.2012.09.026
更新日期:2013-01-01 00:00:00
abstract::The aim of this study was to investigate the extent of calcium ion (Ca(2+)) removal on root dentin after treatment with 1.25% NaOCl, 2.5% NaOCl, 5.25% NaOCl, 2% chlorhexidine (CHX), 2% iodine potassium iodide (IKI), and MTAD in 3 immersion time periods. Extracted human mandibular premolars were bisected longitudinally...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2008.11.016
更新日期:2009-02-01 00:00:00
abstract:INTRODUCTION:The purpose of this retrospective study was to determine the success of the inferior alveolar nerve (IAN) block using either 3.6 mL or 1.8 mL 2% lidocaine with 1:100,000 epinephrine in patients presenting with symptomatic irreversible pulpitis. METHODS:As part of 7 previously published studies, 319 emerge...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.04.007
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION:Hydrogen peroxide tooth bleaching is claimed to cause alterations in dental tissue structures. This study investigated the influence of the number of bleaching sessions on pulp tissue in rats. METHODS:Male Wistar rats were studied in 5 groups (groups 1S-5S) of 10 each, which differed by the number (1-5) o...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.08.007
更新日期:2013-12-01 00:00:00
abstract::Infection control guidelines recommend disinfection of extracted teeth in 10% formalin for 2 weeks before use. Although extracted teeth are routinely used for in vitro endodontic research, the potential influence of formalin has not been evaluated. The purpose of this study was to investigate the effect of formalin st...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2006.04.009
更新日期:2006-09-01 00:00:00
abstract:INTRODUCTION:In recent years, the inflammasome has been determined to play an important role in inflammatory diseases. However, the role of the inflammasome in pulpitis remains unclear. Absent in melanoma 2 (AIM2) is a type of inflammasome that recognizes cytosolic double stranded DNA and forms a caspase-1-activating i...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.07.003
更新日期:2013-11-01 00:00:00
abstract:INTRODUCTION:Calcium hydroxide (Ca[OH]2) is a widely used interappointment dressing, but its antibacterial property is compromised by dentin. Hence, the addition of chlorhexidine (CHX) with Ca(OH)2 has been proposed. However, the antimicrobial efficacy of this mixture compared with Ca(OH)2 alone is currently still deba...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2016.01.020
更新日期:2016-05-01 00:00:00
abstract::The aim of this review was to consider laboratory experiments and clinical studies of calcium hydroxide-based root canal sealers. An extensive search of the endodontic literature was made to identify publications related to calcium hydroxide-based root canal sealers. The articles were assessed for the outcome of labor...
journal_title:Journal of endodontics
pub_type: 杂志文章,评审
doi:10.1016/j.joen.2008.11.026
更新日期:2009-04-01 00:00:00
abstract:INTRODUCTION:This study compared the accuracy of cone beam computed tomography (CBCT) scans made by five different systems in detecting vertical root fractures (VRFs). It also assessed the influence of the presence of root canal filling (RCF), CBCT slice orientation selection, and the type of tooth (premolar/molar) on ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2009.09.013
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:The alterations in dentin tissue depending on increasing age might cause different adhesion capability of bacteria, yielding differences in clinical approaches regarding root canal irrigation. This study, therefore, aimed to evaluate the effects of ethylenediaminetetraacetic acid (EDTA) and sodium hypochlo...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2010.01.008
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to evaluate and compare, clinically and radiographically, the effects of platelet-rich fibrin (PRF) and mineral trioxide aggregate (MTA) as pulpotomy agents in permanent teeth with incomplete root development. METHODS:A total number of 70 children requiring pulpotomy in 70 pe...
journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2014.01.009
更新日期:2014-05-01 00:00:00
abstract::Coconut water is biologically pure and sterile, with a rich presence of amino acids, proteins, vitamins, and minerals. The purpose of this study was to use a collagenase-dispase assay to investigate the potential of a new storage medium, coconut water, in comparison with propolis, Hank's balanced salt solution (HBSS),...
journal_title:Journal of endodontics
pub_type: 杂志文章,收录出版
doi:10.1016/j.joen.2008.01.018
更新日期:2008-05-01 00:00:00
abstract:INTRODUCTION:The present study quantitatively assessed tissue regeneration after regenerative endodontic procedures (REPs) with 2 different apical preparation sizes in mature teeth using magnetic resonance imaging (MRI). METHODS:Eighteen maxillary anterior mature necrotic teeth with periapical lesions were selected fo...
journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2020.01.026
更新日期:2020-05-01 00:00:00
abstract::Interleukin-10 receptor (IL-10R) expression in human, dental pulp, fibroblast cultures was investigated by using the reverse transcriptase-polymerase chain reaction (RT-PCR) technique. After exposure to lipopolysaccharide (LPS) from Prevotella intermedia, the IL-10R mRNA levels increased after 4 h, peaked at 7 h, and ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200301000-00013
更新日期:2003-01-01 00:00:00
abstract:INTRODUCTION:The objective of this study was to investigate the association between chronic apical periodontitis (CAP) and low-birth-weight preterm births (LBWPB). METHODS:Sixty-three women in postpartum period were included in this case-control study. The case group consisted of mothers of LBWPB infants (n = 33), and...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2014.11.018
更新日期:2015-03-01 00:00:00
abstract::To date there has been very little data on the cytotoxic response of different cell lines to root canal sealers. The objective of this study was to determine the cytocompatibility of three different extracts of root canal sealers and to compare the cytotoxic response of these materials on two different primary human o...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200109000-00004
更新日期:2001-09-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to compare the efficacy of the cutting ability of two different instruments, concerning changes in the dentin thickness removed and root canal volume, by using multislice computed tomography scanning. METHODS:Thirty single-rooted mandibular premolars were divided into two equ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.03.036
更新日期:2011-08-01 00:00:00
abstract::Apical periodontitis and its concomitant periapical osteolysis is caused by pulpal infection, and bacterial lipopolysaccharide (LPS) is known to play a major role in the bone resorption process. Little is known concerning the effect of root canal intervisit dressings on residual LPS in root canals after bacterial cell...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)81199-4
更新日期:1993-02-01 00:00:00
abstract::A lack of agreement exists in the literature regarding the anatomical relationship of the mandibular canal to its surrounding structures such as the root apices. The purpose of this investigation was to study the spatial relationship of the mandibular canal to the posterior teeth in dried human mandibles. Twenty-two m...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)81411-1
更新日期:1992-04-01 00:00:00
abstract:INTRODUCTION:The objective of this study was to evaluate the pH and calcium ion release of calcium hydroxide pastes associated with different substances. METHODS:Forty acrylic teeth with simulated root canals were divided into 4 groups according to the substance associated to the calcium hydroxide paste: chlorhexidine...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2009.05.009
更新日期:2009-09-01 00:00:00
abstract:INTRODUCTION:This study compared the efficacy of a reciprocating single-instrument system and a rotary multi-instrument system followed by a supplementary approach with a finishing instrument in removing the filling material from curved canals during retreatment. METHODS:Forty mesial canals from extracted mandibular m...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2016.04.007
更新日期:2016-07-01 00:00:00
abstract::The aim of this study was to investigate the cytotoxic and nitric oxide (NO)-inducing effects of bismuth oxide (Bi(2)O(3))-containing Portland cement (BPC) on human dental pulp cells. We also assessed whether heme oxygenase-1 (HO-1) is involved in BPC-induced cytotoxicity in dental pulp cells. Cytotoxicity and NO prod...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2007.07.012
更新日期:2007-11-01 00:00:00
abstract::Stem cell therapy is a potential strategy to regenerate the dentin-pulp complex, enabling the conservation and restoration of functional teeth. We assessed the efficacy and safety of pulp stem cell transplantation as a prelude before the initiation of clinical trials. Granulocyte-colony stimulating factor (G-CSF) indu...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2014.01.020
更新日期:2014-04-01 00:00:00