Genetic diversity of O-antigen biosynthesis regions in Vibrio cholerae.

Abstract:

:O-antigen biosynthetic (wbf) regions for Vibrio cholerae serogroups O5, O8, and O108 were isolated and sequenced. Sequences were compared to those of other published V. cholerae O-antigen regions. These wbf regions showed a high degree of heterogeneity both in gene content and in gene order. Genes identified frequently showed greater similarities to polysaccharide biosynthesis genes from species other than V. cholerae. Our results demonstrate the plasticity of O-antigen genes in V. cholerae, the diversity of the genetic pool from which they are drawn, and the likelihood that new pandemic serogroups will emerge.

journal_name

Appl Environ Microbiol

authors

Aydanian A,Tang L,Morris JG,Johnson JA,Stine OC

doi

10.1128/AEM.01663-10

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

2247-53

issue

7

eissn

0099-2240

issn

1098-5336

pii

AEM.01663-10

journal_volume

77

pub_type

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