Abstract：
AIM:To examine the accuracy of the aspartate aminotransferase (AST)/Platelet Ratio Index (APRI) and FIB-4, in predicting longitudinal changes in liver histology in hepatitis C virus (HCV) patients. METHODS:Patients that underwent repeat liver biopsies at least 1 year apart from 1999 to 2007 were identified. Liver fibrosis was staged on needle core biopsies evaluated by a single expert liver pathologist. Only laboratory values within 3 mo of the liver biopsies were used. RESULTS:Thirty-six patients met the inclusion criteria with 50% stage 1 on initial biopsy, 25% stage 2, and 22% stage 3. Nineteen of 36 (53%) had progression of fibrosis on repeat biopsies, while 16 (44%) showed no change in stage, and one (3%) showed improvement. Patients that showed progression of fibrosis had significantly higher alanine aminotransferase and aspartate aminotransferase levels than the group that did not show progression. A significant correlation was seen between change in stage of fibrosis and change in APRI (r² = 0.39, P = 0.00001) and a change in FIB-4 (r² = 0.31, P = 0.00004). A change in APRI (ΔAPRI) of 0.18 had 80% positive predictive value (PPV) and 67% negative predictive value (NPV) for progression of fibrosis. A change in FIB-4 (ΔFIB-4) of 0.39 had 75% PPV and 75% NPV for predicting progression of fibrosis. CONCLUSION:ΔAPRI and ΔFIB-4 parallel changes in fibrosis progression, and could be useful tools for clinicians in following patients with active chronic HCV infection.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Mummadi RR,Petersen JR,Xiao SY,Snyder Ndoi
10.3748/wjg.v16.i45.5710subject
Has Abstractpub_date
2010-12-07 00:00:00pages
5710-5issue
45eissn
1007-9327issn
2219-2840journal_volume
16pub_type
杂志文章abstract：:While therapeutic strategies able to change the natural history of the disease are developing, it is of major importance to have available predictive factors for aggressive disease to try and target these therapeutic strategies. Clinical predictors have probably been the most broadly studied. In both Crohn's disease (...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v16.i21.2600
更新日期：2010-06-07 00:00:00
abstract：:Wireless capsule endoscope (WCE) for the investigation of the small bowel is an approved technique both in adults and children (more than 10 years old). The present review provides data on the indications, diagnostic yield, adverse events and limitations of the WCE technique in children and tries to predict the future...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.14.4152
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abstract：AIM:To study the effects of drug treatment on hyperplastic gastric polyps infected with Helicobacter pylori (H pylori). METHODS:Forty-eight patients with hyperplastic gastric polyps (3-10 mm in diameter) infected with H pylori were randomly assigned to a treatment group (n = 24) which received proton-pump inhibitor (o...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,随机对照试验
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abstract：AIM:To observe the therapeutic effects of dexamethasone on rats with severe acute pancreatitis (SAP) and investigate the influences of dexamethasone on the inflammatory mediators and NF-kappaB expression in multiple organs of SAP rats as well as the mechanisms involved. METHODS:Ninety Sprague-Dawley (SD) rats with SAP...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v13.i4.548
更新日期：2007-01-28 00:00:00
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pub_type： 杂志文章
doi：10.3748/wjg.v18.i34.4714
更新日期：2012-09-14 00:00:00
abstract：AIM:To investigate the procedure, feasibility and effects of laparoscope-assisted continuous circulatory hyperthermic intraperitoneal perfusion chemotherapy (CHIPC) in treatment of malignant ascites induced by peritoneal carcinomatosis from gastric cancers. METHODS:From August 2006 to March 2008, the laparoscopic appr...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v16.i15.1901
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journal_title：World journal of gastroenterology
pub_type： 杂志文章,随机对照试验
doi：10.3748/wjg.v12.i25.4061
更新日期：2006-07-07 00:00:00
abstract：AIM:To highlight the intestinal perforation (IP), an uncommon and catastrophic complication after combined liver-kidney transplantation. METHODS:Combined liver-kidney transplantation (LKTx) with left kidney excision and a cyst fenestration procedure on the right kidney were performed on a case of 46-year-old female wi...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v10.i18.2769
更新日期：2004-09-15 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v16.i12.1545
更新日期：2010-03-28 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v18.i39.5576
更新日期：2012-10-21 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v11.i29.4511
更新日期：2005-08-07 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v23.i26.4689
更新日期：2017-07-14 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v9.i1.188
更新日期：2003-01-01 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.15.3684
更新日期：2009-08-07 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v12.i10.1577
更新日期：2006-03-14 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v26.i22.3087
更新日期：2020-06-14 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v22.i30.6944
更新日期：2016-08-14 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v20.i39.14105
更新日期：2014-10-21 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.14.3919
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journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v21.i41.11748
更新日期：2015-11-07 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v19.i13.2092
更新日期：2013-04-07 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v13.i21.2978
更新日期：2007-06-07 00:00:00
abstract：AIM:To understand the role of toll-like receptor 4 (TLR4) signaling in the regulation of iron-regulatory hormone, hepcidin by chronic alcohol consumption. METHODS:For chronic alcohol intake studies, TLR4 mutant mice on C3H/HeJ background and wildtype counterpart on C3H/HeOuJ background were pair-fed with regular (cont...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v20.i34.12161
更新日期：2014-09-14 00:00:00
abstract：AIM:To evaluate the prophylactic efficacy of hepatitis B immunoglobulin (HBIG) in combination with different nucleos(t)ide analogues. METHODS:A total of 5333 hepatitis B surface antigen-positive patients from the China Liver Transplant Registry database were enrolled between January 2000 and December 2009. Low-dose in...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v21.i2.584
更新日期：2015-01-14 00:00:00
abstract：:Globally, over 300 million people are living with viral hepatitis with approximately 1.3 million deaths per year. In 2016, World Health Assembly adopted the Global Health Sector Strategy on viral hepatitis to eliminate hepatitis by 2030. Different World Health Organization member countries are working on hepatitis con...
journal_title：World journal of gastroenterology
pub_type： 社论
doi：10.3748/wjg.v24.i44.4959
更新日期：2018-11-28 00:00:00
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journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v26.i44.7061
更新日期：2020-11-28 00:00:00
abstract：:Unidimensional transient elastography (TE) is a noninvasive technique, which has been increasingly used in the assessment of diffuse liver diseases. This paper focuses on reviewing the existing data on the use of TE in the diagnosis of fibrosis and in monitoring disease progression in alcoholic liver disease, on the f...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v21.i42.11914
更新日期：2015-11-14 00:00:00
abstract：AIM:To evaluate the risk factors for ampullary adenoma and ampullary cancer. METHODS:This case-control study included ampullary tumor patients referred to Peking Union Medical College Hospital. Controls were randomly selected from an existing database of healthy individuals at the Health Screening Center of the same h...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v20.i28.9541
更新日期：2014-07-28 00:00:00
abstract：AIM:To investigate functional change of dendritic cells (DCs) derived from allogeneic partial liver graft undergoing acute rejection in rats. METHODS:Allogeneic (SD rat to LEW rat) whole and 50 % partial liver transplantation were performed. DCs from liver grafts 0 hr and 4 days after transplantation were isolated and...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v9.i1.141
更新日期：2003-01-01 00:00:00
abstract：AIM:Positioning of interventional devices in liver lesions is a challenging task if only CT is available. We investigated the potential benefit of combined PET/CT images for localization of interventional devices in interventional liver studies. METHODS:Thirty lesions each of hyperdense, isodense and hypodense attenua...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v12.i15.2388
更新日期：2006-04-21 00:00:00
