Abstract：
BACKGROUND:Fatty liver disease (FLD), of either alcoholic (AFLD) or non-alcoholic (NAFLD) aetiologies, is characterised histologically by features that are lobulocentric that typically affect zone 3, in contrast with portal-based inflammation characteristics of other forms of chronic liver disease. AIM:The authors aimed to determine the prevalence and significance of portal inflammation in a cohort of adults diagnosed as having AFLD and NAFLD. METHODS:From a histology database, the authors identified 160 patients with biopsy proven AFLD and 214 with NAFLD diagnosed between 1991 and 2001. All liver biopsies were reviewed by one pathologist to evaluate various histological features. RESULTS:More than a mild degree of portal inflammation was found in 47% of AFLD compared with 30% in NAFLD subgroup. A higher degree of portal inflammation in AFLD was associated with a higher mean corpuscular volume, gamma glutamyl transferase (GGT) and alkaline phosphatase, and a lower platelet count and albumin, whereas in NAFLD this was associated with age, presence of diabetes, hypertension, body mass index (BMI), higher fasting blood glucose, cholesterol, alanine transaminase, GGT and ferritin. On regression analysis, portal inflammation was associated with the severity of steatosis (p=0.005), presence of ballooning (p=0.030) in NAFLD and severity of fibrosis in both AFLD and NAFLD (p<0.001). CONCLUSIONS:Portal inflammation is a common component of histological spectrum of both AFLD and NAFLD. In both conditions portal inflammation is associated with clinical and histological features suggestive of advanced disease.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Rakha EA,Adamson L,Bell E,Neal K,Ryder SD,Kaye PV,Aithal GPdoi
10.1136/jcp.2010.079145subject
Has Abstractpub_date
2010-09-01 00:00:00pages
790-5issue
9eissn
0021-9746issn
1472-4146pii
63/9/790journal_volume
63pub_type
杂志文章abstract：:Histological examination of the lower margin of the internal sphincter has demonstrated an increased amount of fibrous tissue in patients with haemorrhoids compared with controls. This finding may be of relevance to the treatment of haemorrhoids by maximal anal dilatation. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.31.3.268
更新日期：1978-03-01 00:00:00
abstract：AIMS:Next Generation Sequencing (NGS)-based BRCA tumour tissue testing poses several challenges. As a first step of its implementation within a regional health service network, an in-house validation study was compared with published recommendations. METHODS:Epithelial ovarian cancer (EOC) formalin-fixed paraffin-embe...
journal_title：Journal of clinical pathology
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doi：10.1136/jclinpath-2020-206840
更新日期：2020-09-07 00:00:00
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journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.38.6.644
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abstract：:In colonic biopsies of 33 patients with acute colitis caused by campylobacter, salmonella, or shigella immunoglobulin containing cells were determined quantitatively using an indirect immunoperoxidase technique and morphometry with a graphic tablet. The findings were compared with those of 10 patients without histolog...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.38.7.774
更新日期：1985-07-01 00:00:00
abstract：:The plasma concentrations of biotin were measured for up to 49 days after injury in nine children with burns and scalds which involved from 12% to 50% of the surface area of the body. Biotin levels below the minimum of the control range were observed in eight of the nine injured children at some stage during the episo...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.29.1.58
更新日期：1976-01-01 00:00:00
abstract：AIMS:Although the autopsy is still the gold standard for quality assessment of clinical diagnoses, autopsy rates have been declining over the last decades to <10%. The aim of this study was to investigate the value of autopsies in the high-tech medicine era by determining the frequency of discrepancies between clinical...
journal_title：Journal of clinical pathology
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doi：10.1136/jclinpath-2013-202122
更新日期：2014-06-01 00:00:00
abstract：:Sections from 100 cervical biopsy specimens were studied by 12 consultant histopathologists to determine the robustness of the existing pathology terminology and classification. Analysis by kappa statistics showed good agreement in the diagnosis of CIN 3 and squamous carcinoma but an inability to distinguish accuratel...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.42.3.231
更新日期：1989-03-01 00:00:00
abstract：:A study has been made of 523 strains of staphylococci on the basis of biological properties, phage typing, and serology. The value of serology in the identification of pathogenic staphylococci has been assessed. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.23.4.370
更新日期：1970-05-01 00:00:00
abstract：:This article reviews recent information concerning the origin of osteoclasts and the local and systemic regulation of their activity. It appears that much of the environmental responsiveness of osteoclasts is mediated by cells of the osteoblastic lineage, which exert a major influence on the localisation, induction, s...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jcp.38.3.241
更新日期：1985-03-01 00:00:00
abstract：AIMS:To compare the expression of immunohistochemical variables between benign and malignant components of malignant peripheral nerve sheath tumour (MPNST) arising within neurofibroma. METHODS:Eight cases of MPNST arising within a neurofibroma, associated with neurofibromatosis type 1 (NF1), were studied. The areas of...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.54.8.631
更新日期：2001-08-01 00:00:00
abstract：:A 65-year-old woman with a history of a left heminephrectomy for renal carcinoma developed hypercalcaemia 11 years after the operation. The same kidney was found to contain a recurrent renal carcinoma. After the radical nephrectomy of the left kidney, hypercalcaemia remitted but reappeared 11 months later. The right k...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.32.3.234
更新日期：1979-03-01 00:00:00
abstract：:The immunofluorescent examination of nasopharyngeal secretions has been compared with conventional cell culture for the diagnosis of respiratory syncytial (RS) virus infection in children under the age of 2 years in Newcastle upon Tyne and Manchester. Two hundred and sixty-eight identifications of RS virus were made b...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.24.4.308
更新日期：1971-05-01 00:00:00
abstract：:A microcomputer system for use in the sequential processing of specimens has been developed in a hospital microbiology department which receives 90 000 specimens a year. Data handling is performed directly through the computers without the use of cards or worksheets. The system facilitates the multistep processing of ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.38.2.215
更新日期：1985-02-01 00:00:00
abstract：:The cardiovascular system is a common target of amyloidosis. This review presents the current clinical and diagnostic approach to amyloidosis, with the emphasis on cardiovascular involvement. It summarises recent nomenclature, classification, and pathogenesis of amyloidosis. In addition, non-invasive possibilities are...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jcp.2004.017293
更新日期：2005-02-01 00:00:00
abstract：:The T(4)-free thyroxine index was used as the thyroid function test of first choice in a district general hospital for one year. Ninety-two patients were assessed both initially and at follow up by a single physician. The index agreed with clinical assessment in 69 out of 74 patients in whom diagnosis was unequivocal....
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.25.3.259
更新日期：1972-03-01 00:00:00
abstract：AIMS:Pim-1 is a serine/threonine kinase that has been shown to play an integral role in the development of a number of human cancers, such as haematolymphoid malignancies. Recently, evidence has shown Pim-1 to be important in prostatic carcinogenesis. In order to further our understanding of its role in prostate cancer...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2005.027672
更新日期：2006-03-01 00:00:00
abstract：AIMS:To isolate RNA and DNA simultaneously from formalin fixed paraffin wax embedded tissue to assess the clonality of enteropathy associated T cell lymphomas and to analyse it in detail by a non-radioactive method of T cell receptor complementarity determining region 3 (CDR3) spectratyping. METHODS:DNA and RNA were i...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.50.10.811
更新日期：1997-10-01 00:00:00
abstract：:The lymphoid tissue of the normal colon is compared with that of colons with diverticular disease. Colons with diverticular disease show a significant increase in the number of lymphoid nodules in areas not containing diverticula. Lymphoid-glandular complexes of the colon were studied in relation to diverticular disea...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.29.3.245
更新日期：1976-03-01 00:00:00
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journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2004.017350
更新日期：2004-11-01 00:00:00
abstract：:An immunological method for detecting fibrin degradation products by tanned cells agglutination has been standardized. The effects of different variables, such as cell concentration, pH, and length of incubation, and the specificity of the reaction, are described. The method is compared with other immunological techni...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.23.4.299
更新日期：1970-05-01 00:00:00
abstract：:The sensitivity of 12 commonly used anti-HIV-1/HIV-2 enzyme immunoassays was evaluated. The assays, each of which utilises at least one synthetic HIV antigen, were tested against a panel of 1092 specimens previously designated anti-HIV positive. In a total of 13 104 tests there were eight false negative results attrib...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.48.5.490
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journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.36.12.1382
更新日期：1983-12-01 00:00:00
abstract：:Several diseases of the small intestine, including gluten-sensitivity, present with malabsorption and a "flat" mucosa. Determination of the mitotic index of epithelial lymphocytes provides a simple, objective method of assessing, and thus of predicting, whether a flat mucosa is due to gluten-sensitivity (index greater...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.36.2.149
更新日期：1983-02-01 00:00:00
abstract：AIMS:To determine how epithelial and stromal thymidine phosphorylase expression affects angiogenesis, rapid tumour growth, and decreased apoptotic activity in cervical cancer at varying stages of progression. METHODS:Epithelial and stromal thymidine phosphorylase expression, the microvessel count (reflected by factor ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.52.8.598
更新日期：1999-08-01 00:00:00
abstract：:A new staining method was developed for the detection of inclusions of Chlamydia psittaci and Chlamydia trachomatis inclusions in cell cultures. Using a combination of methyl green and neutral red stains and washing at pH 5.0, inclusions were stained red while cell cytoplasm was pale pink and cell nuclei were pale gre...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.35.6.642
更新日期：1982-06-01 00:00:00
abstract：:In 12 normal subjects plasma calcium and phosphorus concentrations were estimated during a normal working day. In the individual subjects fluctuations from the fasting values occurred during the period of study, but at no time during that period did the mean values differ significantly from the fasting plasma calcium ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.23.9.772
更新日期：1970-12-01 00:00:00
abstract：:Current techniques for lymphocyte transformation are evaluated and criticised. A simple technique, designed to meet these criticisms, is described in detail, with particular reference to lymphocyte separation and scoring methods. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.21.2.175
更新日期：1968-03-01 00:00:00
abstract：AIMS:The WHO classification describes that combined hepatocellular-cholangiocarcinoma, subtypes with stem-cell features, intermediate-cell subtype (CHC-INT) is composed of tumour cells with features intermediate between hepatocytes and cholangiocytes. However, we previously reported that CHC-INT showed a high positive ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2015-203491
更新日期：2016-10-01 00:00:00
abstract：:Cervical smears from 327 women were examined using the polymerase chain reaction (PCR) targeted to a sequence in the Bam H1 W region of the Epstein-Barr virus (EBV) to determine the prevalence of the virus in the cervix. EBV was detected in 131 (40%) of the 327 women. Of the 235 women with normal cytology, 98 (42%) we...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.47.1.92
更新日期：1994-01-01 00:00:00
abstract：:Aneuploidy is frequently noted in malignant tumours. There is much controversy about its cause and effect in relation to malignant tumours. Failure of the spindle checkpoint caused by mutation of the responsible genes may be one of the important factors for the development of aneuploidy. Telomere dysfunction may also ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jcp.2004.018952
更新日期：2004-12-01 00:00:00
