Abstract:
:Insertion sequences (ISs) are mobile genetic elements in bacterial genomes. In general, intergenic IS elements are probably less deleterious for their hosts than intragenic ISs, simply because they have a lower likelihood of disrupting native genes. However, since promoters, Shine-Dalgarno sequences, and transcription factor binding sites are intergenic and upstream of genes, I hypothesized that not all neighboring gene orientations (NGOs) are selectively equivalent for IS insertion. To test this, I analyzed the NGOs of all intergenic ISs in 326 fully sequenced bacterial chromosomes. Of the 116 genomes with enough IS elements for statistical analysis, 68 have significantly more ISs between convergently oriented genes than expected, and 46 have significantly fewer ISs between divergently oriented genes. This suggests that natural selection molds intergenic IS distributions because they are least intrusive between convergent gene pairs and most intrusive between divergent gene pairs.
journal_name
Genome Biol Evoljournal_title
Genome biology and evolutionauthors
Plague GRdoi
10.1093/gbe/evq040subject
Has Abstractpub_date
2010-01-01 00:00:00pages
584-90issn
1759-6653pii
evq040journal_volume
2pub_type
信件abstract::Animals interact with a diverse array of both beneficial and detrimental microorganisms. In insects, these symbioses in many cases allow feeding on nutritionally unbalanced diets. It is, however, still not clear how are obligate symbioses maintained at the cellular level for up to several hundred million years. Exact ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa032
更新日期:2020-04-01 00:00:00
abstract::Plant genomes encode many lineage-specific, unique transcription factors. Expansion of such gene families has been previously found to coincide with the evolution of morphological complexity, although comparative analyses have been hampered by severe sampling bias. Here, we make use of the recently increased availabil...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evx258
更新日期:2017-12-01 00:00:00
abstract::Each animal microRNA (miRNA) targets many genes for repression. Down-regulation of most of these targets is weak and has no detectable individual phenotypic effect. Whether this extensive weak repression is biologically relevant is a central issue in the debate on miRNA functionality. In the "small (target) pool" view...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evy079
更新日期:2018-04-01 00:00:00
abstract::Determining the rate of protein evolution and identifying the causes of its variation across the genome are powerful ways to understand forces that are important for genome evolution. By using a multitissue transcriptome data set from great tit (Parus major), we analyzed patterns of molecular evolution between two pas...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu157
更新日期:2014-08-01 00:00:00
abstract::Fungi expressing P450nor, an unconventional nitric oxide (NO) reducing cytochrome P450, are considered significant contributors to environmental nitrous oxide (N2O) emissions. Despite extensive efforts, fungal contributions to N2O emissions remain uncertain. For example, the majority of N2O emitted from antibiotic-ame...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evy187
更新日期:2018-09-01 00:00:00
abstract::In the experimental evolution of microbes such as Escherichia coli, many replicate populations are evolved from a common ancestor. Freezing a population sample supplemented with the cryoprotectant glycerol permits later analysis or restarting of an evolution experiment. Typically, each evolving population, and thus ea...
journal_title:Genome biology and evolution
pub_type: 信件
doi:10.1093/gbe/evw054
更新日期:2016-05-09 00:00:00
abstract::Macroevolutionary trends exhibited by retroviruses are complex and not entirely understood. The sloth endogenized foamy-like retrovirus (SloEFV), which demonstrates incongruence in virus-host evolution among extant sloths (Order Folivora), has not been investigated heretofore in any extinct sloth lineages and its prem...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw023
更新日期:2016-02-14 00:00:00
abstract::Mitochondrial (mt) genomes are intensively studied in Ascomycota and Basidiomycota, but they are poorly documented in basal fungal lineages. In this study, we sequenced the complete mtDNA of Rhizophagus sp. DAOM 213198, a close relative to Rhizophagus irregularis, a widespread, ecologically and economical relevant spe...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu268
更新日期:2014-12-19 00:00:00
abstract::piRNA clusters are thought to repress transposable element (TE) activity in mammals and invertebrates. Here, we show that a simple population genetics model reveals a constraint on the size of piRNA clusters: The total size of the piRNA clusters of an organism must exceed 0.2% of a genome to repress TE invasions. More...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa064
更新日期:2020-05-01 00:00:00
abstract::Gene duplication may be an important mechanism for the evolution of new functions and for the adaptive modulation of gene expression via dosage effects. Here, we analyzed the fate of gene duplicates for two strains of a novel group of cyanobacteria (genus Acaryochloris) that produces the far-red light absorbing chloro...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evr060
更新日期:2011-01-01 00:00:00
abstract::Population-level differences in the number of copies of genes resulting from gene duplication and loss have recently been recognized as an important source of variation in eukaryotes. However, except for a small number of cases, the phenotypic effects of this variation are unknown. Data from the Saccharomyces Genome R...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evq043
更新日期:2010-01-01 00:00:00
abstract::Epigenetic variation in natural populations with contrasting habitats might be an important element, in addition to the genetic variation, in plant adaptation to environmental stress. Here, we assessed genetic, epigenetic, and cytogenetic structure of the three Lilium bosniacum populations growing on distinct habitats...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evy010
更新日期:2018-01-01 00:00:00
abstract::Clashes between transcription and replication complexes can cause point mutations and chromosome rearrangements on heavily transcribed genes. In eukaryotic ribosomal RNA genes, the system that prevents transcription-replication conflicts also causes frequent copy number variation. Such fast mutational dynamics do not ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz235
更新日期:2019-11-01 00:00:00
abstract::The predominantly aquatic order Alismatales, which includes approximately 4,500 species within Araceae, Tofieldiaceae, and the core alismatid families, is a key group in investigating the origin and early diversification of monocots. Despite their importance, phylogenetic ambiguity regarding the root of the Alismatale...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv260
更新日期:2016-04-06 00:00:00
abstract::Influenza virus inflicts a heavy death toll annually and resistance to existing antiviral drugs has generated interest in the development of agents with novel mechanisms of action. Favipiravir is an antiviral drug that acts by increasing the genome-wide mutation rate of influenza A virus (IAV). Potential synergistic b...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evx138
更新日期:2017-07-01 00:00:00
abstract::The genome sequences of the plastid and mitochondrion of white spruce (Picea glauca) were assembled from whole-genome shotgun sequencing data using ABySS. The sequencing data contained reads from both the nuclear and organellar genomes, and reads of the organellar genomes were abundant in the data as each cell harbors...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv244
更新日期:2015-12-08 00:00:00
abstract::Prokaryote genomes are the result of a dynamic flux of genes, with increases achieved via horizontal gene transfer and reductions occurring through gene loss. The ecological and selective forces that drive this genomic flexibility vary across species. Bacillus subtilis is a naturally competent bacterium that occupies ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evx270
更新日期:2018-01-01 00:00:00
abstract::Bartonella is a genetically diverse group of vector-borne bacteria. Over 40 species have been characterized to date, mainly from mammalian reservoirs and arthropod vectors. Rodent reservoirs harbor one of the largest Bartonella diversity described to date, and novel species and genetic variants are continuously identi...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evy236
更新日期:2018-11-01 00:00:00
abstract::It is often unavoidable to combine data from different sequencing centers or sequencing platforms when compiling data sets with a large number of individuals. However, the different data are likely to contain specific systematic errors that will appear as SNPs. Here, we devise a method to detect systematic errors in c...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evy199
更新日期:2018-10-01 00:00:00
abstract::This study investigated long-term substitution rate differences using three calibration points, divergences between lobe-finned vertebrates and ray-finned fish, between mammals and sauropsids, and between holosteans (gar and bowfin) and teleost fish with amino acid sequence data of 625 genes for 25 bony vertebrates. T...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evy125
更新日期:2018-07-01 00:00:00
abstract::Plants and fungi display a broad range of interactions in natural and agricultural ecosystems ranging from symbiosis to parasitism. These ecological interactions result in coevolution between genes belonging to different partners. A well-understood example is secreted fungal effector proteins and their host targets, w...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evy023
更新日期:2018-02-01 00:00:00
abstract::Many species are not completely reproductively isolated, resulting in hybridization and genetic introgression. Organellar genomes, such as those derived from mitochondria (mtDNA) and chloroplasts, introgress frequently in natural systems; however, the forces shaping patterns of introgression are not always clear. Here...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw254
更新日期:2017-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are short endogenous RNA molecules that regulate gene expression at the posttranscriptional level and have been shown to play critical roles during animal development. The identification and comparison of miRNAs in metazoan species are therefore paramount for our understanding of the evolution of bo...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evq053
更新日期:2010-01-01 00:00:00
abstract::The Bateson-Dobzhansky-Muller (BDM) model of reproductive isolation by genetic incompatibility is a widely accepted model of speciation. Because of the exceptionally rich biological information about the budding yeast Saccharomyces cerevisiae, the identification of BDM incompatibilities in yeast would greatly deepen o...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evt091
更新日期:2013-01-01 00:00:00
abstract::Corals belong to the most basal class of the Phylum Cnidaria, which is considered the sister group of bilaterian animals, and thus have become an emerging model to study the evolution of developmental mechanisms. Although cell renewal, differentiation, and maintenance of pluripotency are cellular events shared by mult...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw042
更新日期:2016-03-23 00:00:00
abstract::Chagas disease was described by Carlos Chagas, who first identified the parasite Trypanosoma cruzi from a 2-year-old girl called Berenice. Many T. cruzi sequencing projects based on short reads have demonstrated that genome assembly and downstream comparative analyses are extremely challenging in this species, given t...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz129
更新日期:2019-07-01 00:00:00
abstract::In many species, spermatogenesis involves more cell divisions than oogenesis, and the male germline, therefore, accumulates more DNA replication errors, a phenomenon known as male mutation bias. The extent of male mutation bias (α) is estimated by comparing substitution rates of the X, Y, and autosomal chromosomes, as...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evx155
更新日期:2017-09-01 00:00:00
abstract::Orphan genes are defined as genes that lack detectable similarity to genes in other species and therefore no clear signals of common descent (i.e., homology) can be inferred. Orphans are an enigmatic portion of the genome because their origin and function are mostly unknown and they typically make up 10% to 30% of all...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evt009
更新日期:2013-01-01 00:00:00
abstract::Wolbachia is a widely distributed intracellular bacterial endosymbiont among invertebrates. The wStriCN, the Wolbachia strain that naturally infects an agricultural pest Laodelphax striatellus, has a "Jekyll and Hyde" mode of infection pattern with positive and negative effects: It not only kills many offspring by ind...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa006
更新日期:2020-02-01 00:00:00
abstract::Gene duplications and novel genes have been shown to play a major role in helminth adaptation to a parasitic lifestyle because they provide the novelty necessary for adaptation to a changing environment, such as living in multiple hosts. Here we present the de novo sequenced and annotated genome of the parasitic trema...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evab010
更新日期:2021-01-23 00:00:00