Abstract：
BACKGROUND:Angiogenesis is of crucial importance for endometrial tumor growth and Vascular Endothelial Growth Factor (VEGF) is the key mediator of angiogenesis. OBJECTIVE:The purpose of our study was to assess the prognostic value of VEGF and its receptors in relation to endometrioid endometrial carcinomas. MATERIAL AND METHODS:In this study we conducted an immunohistochemical evaluation of VEGF and VEGFRs expression in 84 tissue samples obtained from endometrioid endometrial cancer patients undergoing curative surgical treatment. RESULTS:Out of 84 cancers, strong positive expression of VEGF was seen in 35 (42%) tumors. The overall strong positive rates were 33% for VEGFR-1 and for 15% for VEGFR-2. There was a significant correlation between clinical stage and VEGF and VEGFR-1 overexpression (p=0.027 and p=0.004, respectively). Additionally there was a significant correlation between histological grade and VEGF and VEGFR-1 overexpression (p<0.001 and p<0.01, respectively). The 5-year DFS of patients with VEGF and VEGFR-1 overexpression was significantly lower than that of those with a weakly positive or negative tumor (p<0.001). CONCLUSION:Immunohistochemical evaluation of VEGF and VEGFR-1 overexpression may be a useful marker for predicting 5-year DFS in endometrioid endometrial cancer.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Dobrzycka B,Terlikowski SJ,Kwiatkowski M,Garbowicz M,Kinalski M,Chyczewski Lsubject
Has Abstractpub_date
2010-06-01 00:00:00pages
422-5issue
6eissn
0017-0011issn
2543-6767journal_volume
81pub_type
杂志文章abstract：:The presence of estrogens, their function and targets in male reproductive tract are still not fully understood. Recent studies, basic and clinical indicate an important role of estrogens during germ cell development. In this study the efforts have been made to immunolocalize aromatase P450 as well as estrogen recepto...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to verify clinical diagnosis of cervical incompetence by the use of transvaginal sonography. MATERIAL AND METHODS:101 pregnant women hospitalized at the Pathological Pregnancy Department, Medical University of Lodz in years 2000-2002 because of suspicion of cervical incompetence wer...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
abstract：:Hypothermia is one of the most important factors having an influence on morbidity of the newborns. Physiology of neonatal thermoregulation and thermogenesis is described as well as range of methods used for preventing heat loss and maintaining neutral temperature. An article presents the main reasons of limited thermo...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2003-11-01 00:00:00
abstract：:Maldevelopment of the müllerian ducts occurs in a variety of forms, and each anomaly is distinctive. Nevertheless, some generalizations can be made. A comprehensive preoperative evaluation of patients with suspected uterovaginal malformations is essential, but a clear understanding of the particular anomaly may not be...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-11-01 00:00:00
abstract：:The aim of the paper was to evaluate the anatomical state of uterine adnexa in women operated on due to mechanical infertility. Hydrotubation were previously applied in 31 women stemming from various centres in the country, while in 31 such a treatment was not performed at all. The mentioned groups of women were encum...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The isolation of cortisol and progesterone binding globulin (CBG) from pregnant women serum was performed using affinity and hydrophobic chromatography. The purity and specificity of isolated transcortin was tested by agarose gel electrophoresis using racket and cross immunoelectrophoresis and specific CBG antibodies....
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:The term hypertension in pregnancy stands either for a high blood pressure, which has already developed before pregnancy (i.e., chronic hypertension in pregnancy), or for a pregnancy-associated disease (i.e., pregnancy-induced hypertension). Each form of hypertension may be an isolated phenomenon or constitute a part ...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVES:The ultrasound-guided transversus abdominis plane (TAP) block is a supporting method of pain relief after different types of surgical and gynecological procedures. The aim of the present study was to evaluate the analgesic effects of the TAP-block in patients undergoing caesarean section. MATERIAL AND METHO...
journal_title：Ginekologia polska
pub_type： 杂志文章,随机对照试验
doi：10.5603/GP.a2018.0072
更新日期：2018-01-01 00:00:00
abstract：:Cytogenetic studies were performed in 129 couples with the history of recurrent spontaneous miscarriages. In 8 couples (6.2%) chromosome aberrations were found The most frequent aberrations were reciprocal translocations (in 6 couples). Pericentric inversion of chromosome 9 was detected in 3 couples (2.3%) while the c...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：OBJECTIVES:Evaluation of safety and effectiveness of POP (pelvic organ prolapse) treatment with the use of polypropylene mesh depending on type of mesh and application technique. MATERIALS AND METHODS:We carried out a retrospective study and compared the frequency of perioperative complications and treatment results t...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1610
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to determine serum concentrations of a proinflammatory cytokine, tumor necrosis factor-alpha (TNF-α), in patients with recurrent abortions undergoing treatment with sildenafil or etanercept. MATERIAL AND METHODS:Serum TNF-α concentrations were determined for 24 patients with recurre...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/57823
更新日期：2015-07-01 00:00:00
abstract：MATERIAL AND METHODS:It was a retrospective analysis of fetal echocardiography results (analysis of congenital heart defect (CHD) and functional abnormalities in normal heart anatomy) in 83 fetuses diagnosed and treated in the same institution. RESULTS:In our group of fetuses, the most common structural defect, in add...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：:Since testes and adrenal cortex derive from the same urogenital ridge, adrenal tissue with descending gonads may migrate in early embryonic period. Although most often ectopic tissue undergoes atrophy in some cases, when adrenocorticotrophic (ACTH) overstimulation occurs, the adrenal remnants in the testes may become ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
abstract：:Transvaginal ultrasound scanning was performed on 59 years old women with postmenopausal bleeding in anamnesis. Endometrial thickness was measured at its maximum in both longitudinal and transverse sections of the uterus. Also the thickness of uterus walls and ovaries in 3 planes were measured. Endometrium was irregul...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：:The most important benefit of tocolysis is a 48-hour prolongation of gestational age in order to administer corticosteroids to reduce perinatal mortality and morbidity as well as, if necessary to gain time for "in utero" transfer to a tertiary centre with neonatal facilities. The tocolytic agents used in clinical prac...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2010-02-01 00:00:00
abstract：:This study was performed in 52 women in their early postmenopausal period, divided into two equal groups. The control group included women with menopausal symptoms only, women in the study group demonstrated also pruritus. All women were on estrogen replacement therapy, additionally a bacterial auto-vaccine was admini...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVES:The role of angiogenesis in leiomyosarcomas still remains unclear. The aim of this study was to evaluate the NRP1 expression in the leiomyosarcoma tissues and to find the relations between its expression and the clinical features. MATERIAL AND METHODS:The study group consisted of 50 patients with diagnosis ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.a2018.0002
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVES:To evaluate data regarding neonatal mortality and short term morbidity among iatrogenic late preterm (ILP) and spontaneous late preterm (SLP) twin births, and to estimate whether medical interventions - induction of labor in this particular context, are associated with better or poorer outcomes. MATERIAL AN...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1600
更新日期：2013-06-01 00:00:00
abstract：INTRODUCTION:Malignant neoplasm of the endometrium is the most common malignant neoplasm of the female reproductive system. Toll Like Receptors (TLR) play a significant role in innate and late-immunity against infections or damaged tissues. TLRs are also involved in the development of tumors in their natural microenvir...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2020.0073
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:The objective of this study was to determine the maternal PLAC1 protein levels in early and late onset preec-lampsia. MATERIAL AND METHODS:A total of 135 pregnant women were included in the study, of which 55 were at < 34 weeks of gesta-tion and 80 were at ≥ 34 weeks of gestation, between June and November ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.a2018.0025
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVES:To analyze the prognosis and related risk factors of patients with scarred uterus complicated with central placenta previa. MATERIAL AND METHODS:A total of 272 parturient women admitted to our hospital between June 2013 and December 2016 were selected, of whom 142 cases with central placenta previa were des...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2019.0033
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION:Ectopic pregnancy (EP) is usually located in the Fallopian tube and it has a significant adverse effect on womens fertility Three types of EP treatment include: expectant, medical, and surgical radical (salpingectomy) or conservative (salpingotomy) management. OBJECTIVES:The aim of the study was to compar...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1675
更新日期：2013-12-01 00:00:00
abstract：:Small intestinal tumors are relatively rare, and notoriously difficult to diagnose. In our case 64 years old female was operated because suspicion of ovarian tumor. The complained on recurrent gastrointestinal bleeding. An arteriogram of superior mesenteric artery revealed arteriovenous malformation in the distal part...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：INTRODUCTION:Placenta increta refers to the placenta invading the myometrium. It is a rare but life-threatening condition. The incidence of placenta increta ranges widely from 1 in 540 to 1 in 93,000 deliveries; in Poland it is approximately 0.2% of all deliveries. The occurrence of placenta praevia increta is much low...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：:Two patients aged 35 i 40 years after extensive clinical evaluation were operated by means of combined approach--laparoscopy and vaginal resection of endometriotic tumors. First laparoscopy was performed in order to dissect rectovaginal septum and separate rectum from the vagina in order to facilitate complete vaginal...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：INTRODUCTION:A standard assessment of embryo morphology at given time points does not always allow to transfer the embryo with the highest implantation potential. The effect of transfer of an improper embryo results in a lack of pregnancy or a miscarriage and, as a consequence, exposes the patient to unnecessary emotio...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1728
更新日期：2014-04-01 00:00:00
abstract：:The aim of the work were changes of serum ferritin and iron concentrations in women with leiomyoma of the uterus treated surgically. We took the growth of the leiomyomatous uterus under concern. We observed the lower serum ferritin and iron concentrations before the surgical treatment, and the correlation with the gro...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：UNLABELLED:Preeclampsia is one of the most frequent and dangerous complications of a pregnancy. In preeclamptic pregnancies the spiral arteries are not modified properly. Disturbed blood flow finally leads to hypoxia which is responsible for the dysfunction of the endothelium. Endothelial growth factor (VEGF) and place...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2007-11-01 00:00:00
abstract：:This case report describes a 40-year-old woman, primigravida. On 13,3 weeks of gestation we diagnosed an abnormal flow pattern in the umbilical artery and abnormal hyperechogenic structure in fetal abdomen. In next sonographic examination on 16 weeks of gestation we diagnosed ventriculomegaly and ahydramnion. We also ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2006-05-01 00:00:00
abstract：:One of the mechanisms for direct cell to cell signaling is mediated by gap junctions. These junctions are formed by connexins, transmembrane proteins. Gap junction intercellular communication (GJIC) plays a critical role in tissue development, differentiation of cells, and regulation of tissue homeostasis. Cancer cell...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-07-01 00:00:00
