Abstract：
OBJECTIVES:The aim of the study was to determine serum concentrations of a proinflammatory cytokine, tumor necrosis factor-alpha (TNF-α), in patients with recurrent abortions undergoing treatment with sildenafil or etanercept. MATERIAL AND METHODS:Serum TNF-α concentrations were determined for 24 patients with recurrent miscarriages (aged 32.7 ± 4.64 years) deemed eligible for sildenafil therapy and 7 patients treated with etanercept (aged 37.65 ± 5.45 years). Measurements were performed before and after therapy. The control group included 10 healthy women (aged 33.3 ± 5.49 years), who gave birth at least once without pregnancy-related complications. The levels of serum TNF-α were measured by Elisa. RESULTS:Patients treated with etanercept had significantly elevated levels of TNF-α before therapy as compared to the control group (41.4 ± 28.4 vs. 16.6 ± 7.2 pg/ml). Moreover we found a tendency for the concentration of TNF-α to increase in sera of patients treated with sildenafil after therapy completion (19 ± 29 vs. 15.4 ± 26.7 pg/ml). Treatment with etanercept resulted in a significant reduction of serum TNF-α levels (41.4 ± 28.4 vs. 25.4 ± 3.2 pg/ml). CONCLUSIONS:Therapy of recurrent abortions with anti-TNF-α drugs appears to be encouraging. Administration of blockers of phosphodiesterase type 5 or TNF-α blockers before conception seems to be a promising future therapy of immune-dependent recurrent miscarriages, limiting the teratogenic influence of the drugs on the fetus.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Ohams M,Jerzak M,Górski Adoi
10.17772/gp/57823subject
Has Abstractpub_date
2015-07-01 00:00:00pages
520-4issue
7eissn
0017-0011issn
2543-6767journal_volume
86pub_type
杂志文章abstract：:The aim of the work were changes of serum ferritin and iron concentrations in women with leiomyoma of the uterus treated surgically. We took the growth of the leiomyomatous uterus under concern. We observed the lower serum ferritin and iron concentrations before the surgical treatment, and the correlation with the gro...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：OBJECTIVES:The etiology of intrahepatic cholestasis of pregnancy (ICP) involves environmental, hormonal and genetic factors. It is thought that ICP may be related to the polymorphic variants of several genes involved in the metabolism and transport of bile acids (BA). The goal of our study was to evaluate the possible ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.a2018.0067
更新日期：2018-01-01 00:00:00
abstract：:Two patients aged 35 i 40 years after extensive clinical evaluation were operated by means of combined approach--laparoscopy and vaginal resection of endometriotic tumors. First laparoscopy was performed in order to dissect rectovaginal septum and separate rectum from the vagina in order to facilitate complete vaginal...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:The aim of the work is to present regenerative medicine achievement as an alternative SUI treatment and the variety of injected cells type as well as injection techniques itself with the analysis of their quality and possible the mechanism in which they reduce urinary incontinence symptoms. For over a decade numerous ...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/60973
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVES:The evaluation of sexual life after hysterectomy is still controversial. DESIGN:The aim of the study was to analyse the impact of hysterectomy on frequency and quality of the woman's sexual life. MATERIAL AND METHODS:The total of 539 women operated in II Department of Obstetrics and Gynecology in 1990-2000...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-07-01 00:00:00
abstract：:Serum levels of CA125 turned out to be a valuable parameter not only as a marker of ovarian carcinoma but also in other fields of obstetrics and gynaecology. Up to date most of the studies dealing with the subject remain experimental and their clinical usefulness is not widely acknowledged. Accessible and relatively c...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2003-05-01 00:00:00
abstract：OBJECTIVES:From a theoretical viewpoint, intraperitoneal therapy (i.p.) in-patients with ovarian cancer, a malignancy, which remains mainly, confined to the peritoneal cavity is logical. Intraperitoneal catheters have moved to the forefront as a delivery system in cancer treatment. Authors have described complications ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：:Transvaginal sonography (TVS), computed tomography (CT) and magnetic resonance imaging (MRI) were used for preoperative diagnosis of myometrial and pelvic lymph nodes invasion in patients with endometrial cancer. Results of examinations were compared with histopathological findings. Sensitivity, specificity, efficacy,...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：AIM:The aim of the following work was to assess three-level selective perinatal care in Polish voivodeships in 2008 on the basis of the following parameters: birth rates as well as perinatal death rates, divided into three classes of neonatal weights, in hospitals on each of the three levels. The goal of selective peri...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVES:Richter operation is used for the enterocele and high rectocoele treatment. There are many modifications of the procedure. Alas, not much data concerning complications and the learning curve of Richter operation is currently at our disposal. DESIGN:The aim of the study is to analyze the course of sacrospino...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章
doi：
更新日期：2007-03-01 00:00:00
abstract：INTRODUCTION:Ectopic pregnancy may lead to massive haemorrhage, infertility or death. Prompt diagnosis and treatment are crucial to save patients who would otherwise die. Serum amylase and lipase measurements are known biochemical markers of pancreatic inflammation and a recognized finding that may help diagnose acute ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2009-05-01 00:00:00
abstract：:We present a case of a female neonate, born at 36 weeks of gestation from a monochorionic, diamniotic spontaneous twin pregnancy with congenital epulis, 2.5 cm in size, protruding from the oral cavity. Histopathology revealed a typical granular cell lesion. The other twin, also female, was prenatally diagnosed with co...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1633
更新日期：2013-08-01 00:00:00
abstract：:Hypoxic-ischemic encephalopathy (ENN) concerns neonates born after 35 completed weeks of gestation. The incidence rate has been shown to be 1-6/1000 births and can lead to significant permanent neurological damage, cerebral palsy and even death. Until the whole body cooling and selective brain cooling methods have bee...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：:Adnexal torsion belongs to the group of urgent cases in gynecology Early diagnosis and management can prevent the loss of an ovary and the Fallopian tube. The case of the 14.5-year-old girl was described by the authors. The symptoms were moderate and caused diagnostics problems. During clinical assessment current lite...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to verify clinical diagnosis of cervical incompetence by the use of transvaginal sonography. MATERIAL AND METHODS:101 pregnant women hospitalized at the Pathological Pregnancy Department, Medical University of Lodz in years 2000-2002 because of suspicion of cervical incompetence wer...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
abstract：:The term hypertension in pregnancy stands either for a high blood pressure, which has already developed before pregnancy (i.e., chronic hypertension in pregnancy), or for a pregnancy-associated disease (i.e., pregnancy-induced hypertension). Each form of hypertension may be an isolated phenomenon or constitute a part ...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2002-09-01 00:00:00
abstract：:Paper concerns 293 laparoscopic operations. The most frequent types of laparoscopic operations in presented material were: adhesion lysis in minor pelvis (33.8% cases), cystectomy and cyst-ovariectomy (27.6%) and electrocoagulation of ovarian capsule. Operative laparoscopy because of small injury is useful method in t...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to test the relationship between maternal serum proinflammatory cytokines level and AFI (amniotic fluid index) in pregnancies complicated by premature rupture of membranes (PROM). MATERIALS AND METHODS:The maternal serum levels of IL-6, IL-1 beta and TNF-alfa were assessed in patient...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：UNLABELLED:The purpose of our study was to analyze the efficacy of serum C-reactive protein (CRP), white blood cell count (WBC) and erythrocyte sedimentation rate (ESR) serial evaluations in the prediction of chorioamnionitis in cases of premature rupture of membranes (PROM). MATERIALS AND METHODS:A group of 80 patien...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
abstract：:During menopausal transition not only ovarian production of estrogens but also marked decrease of adrenal androgen production are observed Decreased secretion of adrenal DHEA and DHEA-S result in reduction of peripheral conversion of these steroids into active estrogens and androgens. Intracrinology describes the bios...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-09-01 00:00:00
abstract：:A survey throughout world literary output concerning physiology of respiratory system in pregnancy was made in this work. Metabolical changes caused by the increase of progesterone and other substances concentration and changes of the mechanics of ventilation connected by diaphragm raising caused by the growing uterus...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：1995-06-01 00:00:00
abstract：OBJECTIVES:To analyze the correlation between ultrasound typing and treatment modality of patients with an intrauterine ectopic pregnancy (cervical and cesarean scar). MATERIAL AND METHODS:We retrospectively enrolled 65 patients diagnosed with cesarean scar pregnancy (CSP) or cervical pregnancy (CP) between February 2...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2020.0026
更新日期：2020-01-01 00:00:00
abstract：:Multiple pregnancies are considered high risk. This qualification is associated with the multitude of conditions which are known to complicated these pregnancies. Early diagnosis of these complications is the fundamental element of clinical managements. In numerous cases therapeutic protocols are widely known and in m...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2000-11-01 00:00:00
abstract：:The World Health Organization announced on 12 March 2020 a global pandemic of the new SARS-CoV-2 coronavirus causing COVID-19 disease associated with pneumonia and acute respiratory failure. SARS-CoV-2 has caused so far over 6.66 million recorded cases, of which 393,000 ended in death (as of June 1, 2020). Despite the...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.5603/GP.a2020.0127
更新日期：2020-01-01 00:00:00
abstract：:The opinions about the causes of the endometrial carcinoma have changed since 1995, due to molecular biology progress. The findings concerning the recently discovered suppressor PTEN gene localized on the chromosome 10 -10q23.3, the product of which is a specific phosphatase are especially valuable. The loss of the ge...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2006-04-01 00:00:00
abstract：:Diabetic pregnancy cause a lot of complications where fetal malformation is one of the most serious. Cardiac defects are besides the neural tube ones the most often in this group of pathology. Lack of pregnancy planning and thanks to it hyperglycemia during conceptive period and early embryogenesis increases the risk ...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-10-01 00:00:00
abstract：:Scientific journals are ranked and evaluated to measure their relative importance and influence on science within a specific field. One of the tools most widely used to evaluate and compare journals is the Thomson Reuters Impact Factor In Poland a specific value of a scientist's Impact Factor is required for academic ...
journal_title：Ginekologia polska
pub_type： 社论
doi：
更新日期：2011-08-01 00:00:00
abstract：:Concentrations of iron, zinc and copper were determined in public hair of women with threatened abortion and in full-term pregnancy. The aim of the studies was to find differences between the levels of studied elements in public hair of women with threatened abortion and in full-term pregnancy and to test whether pari...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-07-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to assess the usefulness of various tumor markers (CA125, HE4, bcl2) measured in serum, urine and saliva in the differential diagnosis of adnexal masses. MATERIAL AND METHODS:Our study was conducted at the Başkent University Medical School, Department of Obstetrics and Gynecology, A...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2016.0045
更新日期：2016-01-01 00:00:00
abstract：:Ovarian cancer remains to be a real challenge in spite of considerable progress in many areas of modern medicine. The use of genetic testing for detecting mutations of the BRCA genes has been offering clinical scrutiny between mutated versions of the BRCA genes and higher risk of both breast and ovarian cancer A popul...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2012-01-01 00:00:00
