Abstract：
OBJECTIVES:The etiology of intrahepatic cholestasis of pregnancy (ICP) involves environmental, hormonal and genetic factors. It is thought that ICP may be related to the polymorphic variants of several genes involved in the metabolism and transport of bile acids (BA). The goal of our study was to evaluate the possible role of genetic polymorphic variants of ABC transporters in patients with ICP. MATERIAL AND METHODS:96 women with ICP (mean age of 30.42 years, mean gestational age of 36.83 gestation weeks) and 211 healthy pregnant women (mean age of 30.68 years, mean gestational age of 39.05 gestation weeks) were enrolled in the study. Genetic analysis was performed using a polymerase chain reaction / restriction fragment length polymorphism (PCR/RFLP) method. The following polymorphisms were analysed: 1331T > C (V444A) ABCB11 and 1954A > G (R652G) ABCB4. RESULTS:Our analysis of frequency of genotypes and alleles of the 1954A > G ABCB4 polymorphism revealed no significant differences between the ICP and control groups. For the 1331T > C polymorphism of the ABCB11 gene the results revealed a higher frequency of 1331CC genotypes in the ICP group (39.58% vs. 29.38%. OR = 1.57, p = 0.05). Also, the frequency of the 1331C allele was higher in the ICP group compared to the control group (64.06% vs. 55.69%, OR = 1.42, p = 0.03). CONCLUSIONS:The overrepresentation of mutated variants of the 1331T > C ABCB11 polymorphism in the ICP group suggests its contribution to the etiology of the intrahepatic cholestasis of pregnancy. Analysis of genotypes' co-existence pointed to the possibility of the mutated variants of polymorphism 1954A > G ABCB4 and 1331T > C ABCB11 having a summation effect on the development of ICP.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Piątek K,Kurzawińska G,Magiełda J,Drews K,Barlik M,Malewski Z,Ożarowski M,Maciejewska M,Seremak-Mrozikiewicz Adoi
10.5603/GP.a2018.0067subject
Has Abstractpub_date
2018-01-01 00:00:00pages
393-397issue
7eissn
0017-0011issn
2543-6767pii
VM/OJS/J/58392journal_volume
89pub_type
杂志文章abstract：:The isolation of cortisol and progesterone binding globulin (CBG) from pregnant women serum was performed using affinity and hydrophobic chromatography. The purity and specificity of isolated transcortin was tested by agarose gel electrophoresis using racket and cross immunoelectrophoresis and specific CBG antibodies....
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：AIM OF STUDY:To define a relationship between emergency and elective indications for cesarean section and quantitative changes of percentage and quantity of T and B lymphocytes and their subpopulations in healthy full-term neonates. MATERIAL AND METHODS:The study included 43 healthy neonates born in the years 1998 - 2...
journal_title：Ginekologia polska
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doi：
更新日期：2009-10-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1663
更新日期：2013-11-01 00:00:00
abstract：:Concentration of thyroxine triiodothyronine and reverse-triiodothyronine in serum blood of 30 pregnant women were estimated, like a longitudinal study from 5 to 41 week of pregnancy. Significant increase of concentration of all hormones was observed. We presented also estimation of iodothyronines in blood serum in lab...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:Concentrations of iron, zinc and copper were determined in public hair of women with threatened abortion and in full-term pregnancy. The aim of the studies was to find differences between the levels of studied elements in public hair of women with threatened abortion and in full-term pregnancy and to test whether pari...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-07-01 00:00:00
abstract：UNLABELLED:The purpose of our study was to analyze the efficacy of serum C-reactive protein (CRP), white blood cell count (WBC) and erythrocyte sedimentation rate (ESR) serial evaluations in the prediction of chorioamnionitis in cases of premature rupture of membranes (PROM). MATERIALS AND METHODS:A group of 80 patien...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2016.0014
更新日期：2016-01-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-08-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/2399
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1975-09-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1633
更新日期：2013-08-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.5603/GP.a2018.0047
更新日期：2018-01-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1979-02-01 00:00:00
abstract：:9.98% of all gynecological surgical interventions made at the Clinic in Zabrez from 1965 to 1971 were for ectopic pregnancy. 157 cases of ectopic pregnancy were chosen at random for clinical analysis. Microscopic examinations of the excised oviduct were made in order to establish the cause of tubular implantation. ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1975-06-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：1993-01-01 00:00:00
abstract：:Uterine septum is the major intrauterine disorder associated with infertility and recurrent abortions. The aim of the study was to find out what is the effectiveness of hysteroscopic intrauterine septum resection in terms of reproductive outcome and in comparison with conventional procedure. The mean follow up period ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-10-01 00:00:00
abstract：:Women have three very important physiological functions that are not observed in men--menstruation, pregnancy and lactation. Each of these mechanisms influences pharmacokinetics and pharmacodynamics of many drugs. Individualization of pharmacotherapy is a major challenge of modern medicine. The differences in response...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/2002
更新日期：2015-02-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-03-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：OBJECTIVES:To assess the effectiveness of the donor-block biopsies with a 2 mm-size needle in endometrioid endometrial cancer (EEC) in the tissue microarray (TMA) technique and the application of the TMA for estrogen receptors (ER) and progesterone receptors (PR) expression in EEC. MATERIAL AND METHODS:The study exami...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
abstract：:Endometrial cancer is one of the most frequently diagnosed malignant neoplasms among women. In Poland, it is in the fourth place in terms of incidence. The highest morbidity concerns women aged 50-70 years, however it may also appear in women in their reproductive period. Endometrial cancer concerns about 3% of premen...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-03-01 00:00:00
abstract：:An increase in alpha-amylase activity with parallel decrease in glucose concentration in amniotic fluid is observed during pregnancy. This interdependence is a theoretical basis for using an alpha-amylase/glucose index in fetal maturity evaluation. The aim of the study was to investigate usefulness of the alpha-amylas...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
abstract：:Sensibility and specificity of transvaginal ultrasonography and diagnostic hysteroscopy were compared in 211 infertile women. Examinations were performed between 1996-2000 in I-st Department of Obstetrics and Gynecology Warsaw Medical University--Poland. Comparing results we concluded high compatibility of transvagina...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND:Embryonal rhabdomyosarcoma in a form of a polyp of the uterine cervix occurs mainly in young women in their second decade of life. The characteristic microscopic features are: the submucosal cambium layer and the presence of rhabdomyoblasts in the stroma. So far the treatment has not been well defined and ra...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2011-11-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2004-08-01 00:00:00
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journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1999-05-01 00:00:00
