Abstract：
INTRODUCTION:Malignant neoplasm of the endometrium is the most common malignant neoplasm of the female reproductive system. Toll Like Receptors (TLR) play a significant role in innate and late-immunity against infections or damaged tissues. TLRs are also involved in the development of tumors in their natural microenvironment. TLRs play an important role in angiogenesis, necessary for survival and growth of the tumor. Hypoxia playing a critical role in angiogenesis, carcinogenesis, tumor progression and distant metastasis is primarily mediated through hypoxia inducible factors (HIFs). Vascular endothelial growth factor family proteins (VEGF) are also strongly involved in tumor angiogenesis and their action is strongly associated with TLR receptors. OBJECTIVES:The aim of the study was to correlate the expression of selected TLRs and VEGFR's as well as HIF1α with clinicopathological data of endometrial cancer patients. MATERIAL AND METHODS:123 neoplastic endometrial samples were included in the study. 51 samples of healthy endometrium served as control. The expression of TLR1, TLR2, TLR3, TLR4, VEGFR1 and VEGFR2, VEGF-A and HIF1α was examined after RNA isolation at the mRNA level by Real Time-PCR. RESULTS:We have noted a significant correlation between the expression of selected TLR and VEGFR's and clinical stage as well as pathological grading of endometrial cancer. CONCLUSIONS:Received correlations confirm a significant contribution of some TLR expression and the receptor for VEGF in the pathogenesis of epithelial endometrial cancer.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Wojcik-Krowiranda KM,Forma E,Bienkiewicz A,Cwonda L,Wronska-Stefaniak J,Brys Mdoi
10.5603/GP.2020.0073subject
Has Abstractpub_date
2020-01-01 00:00:00pages
439-446issue
8eissn
0017-0011issn
2543-6767pii
VM/OJS/J/67992journal_volume
91pub_type
杂志文章abstract：:Venous insufficiency can be defined as a fixed venous outflow disturbance of the limbs. It is caused by the malfunction of the venous system, that may or may not be associated with venous valvular insufficiency and may involve the superficial or deep venous system of the lower limbs, or both. The CEAP scale includes c...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/1540
更新日期：2013-01-01 00:00:00
abstract：:Two groups of rats (a control group and the group examined) were administered intraperitoneally supraphysiological doses of hCG in order to induce a "down regulation" effect on the level of receptors LH and to achieve the desensibilization of Leydig cells. The authors tried to find out at which stage of sequence of ch...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：:Preterm labor remains to be one of the most important challenges of contemporary perinatology and constitutes the main reason of perinatal mortality and prematurity of neonates. Studies on preterm labor have confirmed the mutual interactions of several different hormonal systems while the activation of hypothalamic- p...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2014-02-01 00:00:00
abstract：:One of the principal features of the malignant process is the ability of the tumor to form metastases. In case of endometrial cancer pelvic and paraaortic lymph nodes and ovaries are the most frequent sites of metastases. In some cases metastases to the distant sites like the lungs and liver occur. The diagnosis of st...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：:There have been many advances in perinatal medicine, but few as impressive as those in Rh-disease. Over several decades, we have seen a disease, which once caused the perinatal death of half of all Rh-immunized pregnancies, almost disappear. The success of this medical campaign should serve as a model for the conqueri...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:The paper presents the course of treatment and results of pathological changes in the uterine cervix in 41 patients who underwent cryotherapy by means of a cryotherapeutic apparatus UK-32, using liquid nitrogen as cryogenic fluid. Complete recovery in the form of typical stratified squamous epithelium was achieved in ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：OBJECTIVES:Intrahepatic cholestasis in pregnancy (ICP) is a pregnancy-specific liver disorder. Its etiology is not fully understood. Increasing evidence indicates the important role of vitamin D and the vitamin D receptor (VDR) in this disorder. The presence of polymorphic variants in the VDR gene could influence its a...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.a2020.0135
更新日期：2020-01-01 00:00:00
abstract：:Authors had retrospectively analyzed basic exponents of perinatal care of 256 pregnant diabetic woman in years 1993-1998 hospitalized and delivered in Clinic of Obstetrics and Gynaecology in the town of Bytom. Our results were very similar to the other of Referent Centres Of Technical Methods Bank Used in Diagnostic a...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1999-10-01 00:00:00
abstract：:Natural cytotoxic activity in the umbilical blood was estimated in 52 healthy newborns. Mononuclear cells were isolated from the umbilical blood using Boym's method. The mean natural cell cytotoxicity in the examined group was 7.05 +/- 0.9 (SD). ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：OBJECTIVE:To analyse deliveries after a previous cesarean section. STUDY DESIGN:The way of birth of 262 patients between 1993-1995 in the Ist Department of Obstetrics and Gynaecology of Warsaw University Hospital was analysed. Material was divided into two groups: an elective cesarean section operation was performed o...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:Fetal face is the key anatomical location, both psychologically and clinically for the mother and the clinician. Ultrasound prenatal examination of the maxillofacial region allows to evaluate the fetal face in the first weeks of gestation. In ambulatory intravaginal ultrasound, sensitivity of the facial defect detecti...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/1643
更新日期：2013-09-01 00:00:00
abstract：:Concentrations of iron, zinc and copper were determined in public hair of women with threatened abortion and in full-term pregnancy. The aim of the studies was to find differences between the levels of studied elements in public hair of women with threatened abortion and in full-term pregnancy and to test whether pari...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-07-01 00:00:00
abstract：OBJECTIVES:Surgical site infection (SSI) following gynecologic oncology surgery is a severe problem for both patient and surgeon in terms of increasing morbidity, length of hospital stay, anxiety, and costs. In this prospective, randomized, controlled study we investigated the effect of subcutaneous rifampicin and povi...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.a2020.0134
更新日期：2020-01-01 00:00:00
abstract：:A group of 15 women between the ages of 24-45 were given intraamiotic does of 40 mg of prostagladin F2alpha (PGF2alpha; Enzaprost) in a single dose so as to terminate pregnancy. These pregnancies, between the 15th- 24th weeks, were terminated for medical reasons. 12 hours elapsed between the time of intraamniotic ad...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1988-09-01 00:00:00
abstract：INTRODUCTION:Placenta increta refers to the placenta invading the myometrium. It is a rare but life-threatening condition. The incidence of placenta increta ranges widely from 1 in 540 to 1 in 93,000 deliveries; in Poland it is approximately 0.2% of all deliveries. The occurrence of placenta praevia increta is much low...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：:The paper presents a simple and cheap method of transvaginal hydro-laparoscopy used for the observation women pelvic organs. The method may be useful to diagnose sterility, indefinite pains the pelvis or to control the patients previously undergoing operations. Hydro-laparoscopy was carried out in 12 patients by means...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：:Concentration of thyroxine triiodothyronine and reverse-triiodothyronine in serum blood of 30 pregnant women were estimated, like a longitudinal study from 5 to 41 week of pregnancy. Significant increase of concentration of all hormones was observed. We presented also estimation of iodothyronines in blood serum in lab...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:In the group of 213 women with diagnosed endometriosis, after the histological analysis of the samples obtained during surgical procedure the following factors have been determined: the character and frequency of complaints, prevalence of the disease depending on the age of patients, it's localisation, coexistence wit...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：OBJECTIVES:The aim of this study is to assess the choroidal thickness (CT) with use of EDI-OCT in patients before and after delivery depending on the mode of delivery. MATERIAL AND METHODS:The study involved 146 eyes of 73 patients aged 20-34 years, after natural labour (66 eyes) and C-section (80 eyes). Main inclusio...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.a2020.0137
更新日期：2020-01-01 00:00:00
abstract：:Subarachnoid haemorrhage (SAH) from an intracranial aneurysm or arteriovenous malformation is a grave complication of pregnancy. Authors critically analyzed 12 cases of verified SAH during pregnancy from an 11 identified and 1 unidentified cerebral vascular malformation. Aneurysms were responsible for SAH in 7, and ar...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：OBJECTIVE:Angiogenesis in malignant tumors is a prognostic factor associated with tumor growth and metastasis. The aim of the research was: determination of the angiodensity rate in two immunohistochemical techniques, estimation of the value of the examined parameter at different stages of clinical progression and hist...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：UNLABELLED:In our study the management and outcomes in 211 women with premature rupture of the membranes at term was analyzed. According to the time elapsed since PROM to delivery the study group was divided into four groups: within 6 h, within 6-12 h, within 12-24 h and over 24 h after PROM. The analysis was focused o...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-10-01 00:00:00
abstract：:This paper attempts to assess the value of the dynamical examinations of the concentrations of the pituitary gonadotropin LH, FSH, PRL in the menstrual cycle. RIA were made on 22 sterile women with monophasic cycle and 119 sterile women with biphasic cycle in comparison with 17 women who delivered at least one child w...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：OBJECTIVES:Environmental factors may play equally critical role as genes in facial embryogenesis. It was suggested that cleft palate occurring in association with cleft lip may result from environmental factors that affect development of both the lip and the palate. Cleft lip forms from the third through seventh week o...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2006-04-01 00:00:00
abstract：UNLABELLED:Preeclampsia is one of the most frequent and dangerous complications of a pregnancy. In preeclamptic pregnancies the spiral arteries are not modified properly. Disturbed blood flow finally leads to hypoxia which is responsible for the dysfunction of the endothelium. Endothelial growth factor (VEGF) and place...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:To assess the results of clomiphene citrate ovarian stimulation vs laparoscopic electrocoagulation of the ovaries in infertile women with PCOS. DESIGN:47 women with PCOS were included into the study. 25 of them had ovarian stimulation using clomiphene citrate (100 mg for 5 consecutive days, during 6 cycle) a...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:This paper sums up the results of treatment with laparoscopy the patients suffering from infertility of unknown reason. Laparoscopy was performed in 75 patients and only in 21.3% of cases the reason of infertility remained unclear. In most of infertile women (90%) different factors of infertility were revealed--among ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:A review of the literature for searching of biochemical marker of endometriosis is presented. The investigations with CA 125, antiendometrial antibodies, placental protein 14 and others have not established a sensitive screening test for predicting endometriosis, especially in early stages of the disease. Most authors...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-01 00:00:00
abstract：:The expert panel recommendations are issued in order to increase the number of patients with urinary incontinence and overactive bladder receiving appropriate care. The expert panel recommends that urologists, gynecologists and other physicians interested in the field of incontinence should Incontinence question shoul...
journal_title：Ginekologia polska
pub_type： 杂志文章,实务指引
doi：
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVES:Evaluation of safety and effectiveness of POP (pelvic organ prolapse) treatment with the use of polypropylene mesh depending on type of mesh and application technique. MATERIALS AND METHODS:We carried out a retrospective study and compared the frequency of perioperative complications and treatment results t...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1610
更新日期：2013-07-01 00:00:00
