Abstract:
:In this article we review the value and utility of the minipig as an animal model in regulatory toxicity testing. Our review is based on detailed consideration of the comparative biology of the minipig, and of the practical features of toxicity testing in the minipig. The minipig presents a favourable profile as a non-rodent toxicology model, in terms of the similarity to man and also in terms of applicability to different study types. Studies of general toxicology can be performed in the minipig by oral, cutaneous, parenteral and inhalation routes. For reproductive toxicology studies the minipig offers numerous advantages as a non-rodent model although the lack of placental transfer of macromolecules may limit the role of the minipig in reproductive testing of biotechnology products. For safety pharmacology studies the minipig is an advantageous model, particularly as regards the cardiovascular system. The immune system of the pig is better characterized than that of the dog, making the pig an interesting alternative model to the nonhuman primate for therapeutic approaches based on manipulation of the immune system. Overall, this review leads us to believe that the minipig might be a better non-rodent toxicology model than the dog. At the present time, however, insufficient comparative data is available to permit a rigorous evaluation of the predictivity of the minipig for human drug-induced toxicities and research is urgently needed to provide experimental data for evaluation of the hypothesis that minipig studies may better reflect human drug-induced toxicities than studies performed in traditional non-rodent toxicology models. It would be of particular value to gain a better vision of the potential utility of the minipig as a model for the safety testing of new biologics, where the minipig could potentially replace the use of non-human primates in the testing of some new products.
journal_name
J Pharmacol Toxicol Methodsjournal_title
Journal of pharmacological and toxicological methodsauthors
Bode G,Clausing P,Gervais F,Loegsted J,Luft J,Nogues V,Sims J,Steering Group of the RETHINK Project.doi
10.1016/j.vascn.2010.05.009subject
Has Abstractpub_date
2010-11-01 00:00:00pages
196-220issue
3eissn
1056-8719issn
1873-488Xpii
S1056-8719(10)00082-1journal_volume
62pub_type
杂志文章,评审abstract:INTRODUCTION:Simultaneous recording of electrical potentials from multiple cells may be useful for physiological and pharmacological research. The present study aimed to establish an in vitro cardiac hypoxia experimental platform on the microelectrode array (MEA). METHODS:Embryonic rat cardiac myocytes were cultured o...
journal_title:Journal of pharmacological and toxicological methods
pub_type: 杂志文章
doi:10.1016/j.vascn.2009.02.005
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abstract:INTRODUCTION:Opioid withdrawal syndrome is a critical component of opioid abuse and consists of a wide array of symptoms including increases in pain sensitivity (hyperalgesia). A reliable preclinical model of hyperalgesia during opioid withdrawal is needed to evaluate possible interventions to alleviate withdrawal. The...
journal_title:Journal of pharmacological and toxicological methods
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journal_title:Journal of pharmacological and toxicological methods
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doi:10.1016/s1056-8719(97)00012-9
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abstract:INTRODUCTION:The Health and Environmental Sciences Institute of the International Life Sciences Institute (ILSI/HESI) Cardiovascular Safety Subcommittee outlined a set of in vivo telemetry studies to determine how well this preclinical model identified compounds known to cause torsades de pointes (TdP) and prolong QT i...
journal_title:Journal of pharmacological and toxicological methods
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journal_title:Journal of pharmacological and toxicological methods
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journal_title:Journal of pharmacological and toxicological methods
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journal_title:Journal of pharmacological and toxicological methods
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pub_type: 杂志文章
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journal_title:Journal of pharmacological and toxicological methods
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Journal of pharmacological and toxicological methods
pub_type: 杂志文章
doi:10.1016/1056-8719(95)00019-e
更新日期:1995-08-01 00:00:00
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journal_title:Journal of pharmacological and toxicological methods
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更新日期:2017-09-01 00:00:00
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journal_title:Journal of pharmacological and toxicological methods
pub_type: 杂志文章
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更新日期:2005-11-01 00:00:00
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journal_title:Journal of pharmacological and toxicological methods
pub_type: 杂志文章,评审
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abstract:INTRODUCTION:Most preclinical trials are designed to identify potential torsadogenicity test only for surrogates of torsade de pointes, most commonly prolongation of the heart rate corrected QT interval (QTc). This study was conducted to determine which correction method best accounts for the effects of changes in the ...
journal_title:Journal of pharmacological and toxicological methods
pub_type: 杂志文章
doi:10.1016/j.vascn.2005.04.013
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abstract:INTRODUCTION:Dipeptidyl peptidases (DPPs) 8 and 9 are homologous, cytoplasmic postproline-cutting enzymes, which have similar enzymatic activity and preferred substrates as DPP4. DPP4 is a well-known target for treating diabetes mellitus. With the increased concern of non-selectivity and toxicities caused by DPP4 inhib...
journal_title:Journal of pharmacological and toxicological methods
pub_type: 杂志文章
doi:10.1016/j.vascn.2014.11.002
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to evaluate the feasibility of using gel electrophoresis combined with autoradiographic image analysis for quantitating protein drug concentrations in biological fluid for pharmacokinetic studies. METHODS:Protein drugs were iodinated using the Iodogen reagent and injected int...
journal_title:Journal of pharmacological and toxicological methods
pub_type: 杂志文章
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journal_title:Journal of pharmacological and toxicological methods
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journal_title:Journal of pharmacological and toxicological methods
pub_type: 杂志文章,评审
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journal_title:Journal of pharmacological and toxicological methods
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更新日期:2007-07-01 00:00:00
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journal_title:Journal of pharmacological and toxicological methods
pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
abstract:INTRODUCTION:The ability to quantify systemic concentrations of protein therapeutics is complicated by the presence of endogenous analyte, specific binding proteins, and nonspecific matrix components in biological matrices (Lee & Ma, 2007). Further complications can be introduced following pegylation whereby polyethyle...
journal_title:Journal of pharmacological and toxicological methods
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Journal of pharmacological and toxicological methods
pub_type: 杂志文章
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journal_title:Journal of pharmacological and toxicological methods
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更新日期:2020-01-01 00:00:00
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journal_title:Journal of pharmacological and toxicological methods
pub_type: 杂志文章
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journal_title:Journal of pharmacological and toxicological methods
pub_type: 杂志文章
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journal_title:Journal of pharmacological and toxicological methods
pub_type: 杂志文章
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