Abstract：
:Thresholds of neurons to sounds were compared as a function of central auditory structure [ventral cochlear nucleus (VCN), dorsal cochlear nucleus (DCN), and inferior colliculus (IC)] in young and middle-aged C57BL/6J mice (multiple- and single-unit recordings) and in young and old CBA/J mice (single-unit recordings). Middle-aged C57 mice show progressive loss of sensitivity to high frequencies and noise due to cochlear pathology; CBA mice show little loss of sensitivity through most of their lifespan. Multiple-unit threshold curves (MTCs) for tones indicated that neurons in the C57 VCN suffered a greater degree of age-related loss of sensitivity than neurons in the IC (from an earlier study). Furthermore, whereas the low frequency portions of MTCs in IC neurons in high frequency tonotopic regions typically become 'sensitized' in middle-aged C57 mice (i.e., lower thresholds than young mice), such was not the case for VCN neurons. In contrast to VCN neurons, MTCs of the population of DCN neurons studied were statistically indistinguishable from those of the IC. Measurements of single-unit response areas in C57 mice corroborated the MTCs. In CBA mice, little effect of age was found in comparing single-unit response areas of young and old mice. The findings indicate that sensorineural impairment in middle-aged C57 mice is accompanied by threshold changes that are more severe in the VCN than in the IC or DCN. Because the VCN and DCN are believed to play different roles in hearing, the functions they support should, likewise, be affected to different extents by age-related hearing loss.
journal_name
Hear Resjournal_title
Hearing researchauthors
Willott JF,Parham K,Hunter KPdoi
10.1016/0378-5955(91)90215-usubject
Has Abstractpub_date
1991-05-01 00:00:00pages
78-94issue
1eissn
0378-5955issn
1878-5891pii
0378-5955(91)90215-Ujournal_volume
53pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Synaptic bodies (SBs) associated with rings of synaptic vesicles and well-defined, pre- and post-synaptic membrane structures are indicators of maturity in most hair cell-afferent nerve junctions. The role of the SBs remains elusive despite several experiments showing that they may be involved in storage of neurotrans...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90135-n
更新日期：1993-04-01 00:00:00
abstract：:We determined velocity discrimination thresholds and Weber fractions for sounds revolving around the listener at very high velocities. Sounds used were a broadband white noise and two harmonic sounds with fundamental frequencies of 330 Hz and 1760 Hz. Experiment 1 used velocities ranging between 288°/s and 720°/s in a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.07.014
更新日期：2014-10-01 00:00:00
abstract：:The electrically evoked compound action potential (CAP) of the auditory nerve exhibits two peaks, termed N0, at 350 microseconds latency, and N1, at 550 microseconds latency. At low stimulus intensities the CAP consists solely of the long latency N1 peak. As the stimulus strength is increased the higher threshold N0 a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(84)90051-0
更新日期：1984-06-01 00:00:00
abstract：:Dominant white spotting W/W(v) and W(v)/W(v) mice are well-known mutants that lack strial intermediate cells in their cochlea and manifest hereditary sensorineural hearing loss. We recently reported marked thickening of and IgG deposition on the basement membrane of strial capillaries in W/W(v) mutant mice, similar to...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.05.013
更新日期：2005-11-01 00:00:00
abstract：:Glass microelectrodes were introduced into the stria vascularis (SV) to measure the DC potential profile of the SV in vivo from its apical as well as basal side. The K+ concentration gradient in the lateral cochlear wall was measured by means of double barrel K+-selective microelectrodes. A positive potential 10.4 +/-...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90077-3
更新日期：1987-01-01 00:00:00
abstract：:Healthy guinea pigs were exposed to broad band noise at levels between 95 and 115 dBA for 7 days. A significant decrease of the sound-induced cochlear responses, together with a substantial increase of the endocochlear potential, was observed in guinea pigs exposed to noise at 105 or 115 dBA. Microsamples of the endol...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(79)90004-2
更新日期：1979-12-01 00:00:00
abstract：:Within auditory pathways, the intrinsic electrical properties of neurons, and in particular their complement of potassium channels, play a key role in shaping the timing and pattern of action potentials produced by sound stimuli. The Kv9.1 gene encodes a potassium channel alpha subunit that is expressed in a variety o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00117-9
更新日期：2000-09-01 00:00:00
abstract：:This study addressed the hypotheses that the growth of the level of distortion product otoacoustic emissions (LDP) with primary-tone level reflects the behavior of a third-order nonlinear polynomial system, and that two sources exist for these distortion products. The results indicated that the 2f1-f2 otoacoustic emis...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90016-t
更新日期：1993-12-01 00:00:00
abstract：:Georg von Békésy designed the instruments needed for his research. He also created physical models of the cochlea allowing him to manipulate the parameters (such as volume elasticity) that could be involved in controlling traveling waves. This review is about the specific devices that he used to study the motion of th...
journal_title：Hearing research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.heares.2012.08.009
更新日期：2012-11-01 00:00:00
abstract：:Electrically evoked auditory brainstem response (EABR) recordings were made from 38 humans implanted with one of three cochlear prostheses, and from 25 cats. Recognizable auditory potentials were identified in 27 of the profoundly deaf implanted subjects. In both cats and humans EABR waveform morphology and magnitude ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(86)90033-x
更新日期：1986-01-01 00:00:00
abstract：:The middle ear is a sophisticated and complex structure with a variety of functions, yet a delicate organ prone to injuries due to various reasons. Both, understanding and reconstructing its functions has always been an important topic for researchers from medical and technical background. Currently, human temporal bo...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.12.025
更新日期：2016-10-01 00:00:00
abstract：:Fluorescent tags and fluorophore-conjugated molecular probes have been extensively employed in histological studies to demonstrate nanoparticle distribution in inner ear cell populations. However, autofluorescence that exists in the rodent cochleae disturbs visualization of the fluorescent tags and fluorophore labelin...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.07.006
更新日期：2010-10-01 00:00:00
abstract：:Following hair cell elimination in severely traumatized cochleae, differentiated supporting cells are often replaced by a simple epithelium with cuboidal or flat appearance. Atoh1 (previously Math1) is a basic helix-loop-helix transcription factor critical to hair cell differentiation during mammalian embryogenesis. F...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.02.007
更新日期：2008-06-01 00:00:00
abstract：:The auditory system consists of an intricate set of connections interposed between hierarchically arranged nuclei. The ascending pathways carrying sound information from the cochlea to the auditory cortex are, predictably, altered in instances of hearing loss resulting from blockage or damage to peripheral auditory st...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2016.05.018
更新日期：2017-01-01 00:00:00
abstract：:Thresholds for responses to tone bursts in the primary auditory field of pentobarbital-anesthetized rat are significantly lower for local field potentials (5.60 dB+/-1.76 S.E.M.) than for multiple unit discharges (17.80 dB+/-3.17), recorded simultaneously from the same microelectrode. The characteristic frequencies (C...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00333-7
更新日期：2002-05-01 00:00:00
abstract：:This paper describes the development of a protocol that can be used to detect collagen II in the healthy adult basilar membrane (BM) at the electron microscopic level. This protocol required aggressive epitope exposure techniques to break the crosslinks that bind the collagen molecules tightly into fibrils and to remo...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00313-1
更新日期：2002-04-01 00:00:00
abstract：:Stress can be a significant factor influencing ear pathologies and is often reported to trigger the symptoms of Meniere's disease. Both physiological and psychological stress provokes the release of prolactin from the pituitary thus allowing the classification of prolactin as a major stress hormone. We investigated th...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.11.015
更新日期：2005-05-01 00:00:00
abstract：:Using morphological criteria, death pathways in outer hair cells (OHCs) were determined in chinchilla organs of Corti that had been exposed to a high- or moderate-level octave band of noise (OBN) centered at either 0.5 or 4-kHz. The specimens were part of our large collection of plastic-embedded flat preparations of c...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2006.10.004
更新日期：2007-01-01 00:00:00
abstract：:Tone-burst-evoked compound action potentials (CAP) from the guinea pig round window (RW) are altered by DC current injection through the RW. The CAP waveform consists of a series of interleaved negative and positive peaks (N(1), P(1), N(2), P(2) etc.) of decreasing amplitude. During positive DC current injection (arou...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/S0378-5955(03)00404-0
更新日期：2004-04-01 00:00:00
abstract：:One objective electrophysiological test for deafness involves presenting a brief acoustic stimulus to a subject and measuring the electrical activity evoked in the muscle located just behind the ear (the post-auricular muscle or PAM). Although this electrical response has been known for many years, it has been ignored...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00159-8
更新日期：1999-12-01 00:00:00
abstract：:Cochlear microphonics (CM) were recorded with differential electrodes from several locations in the guinea pig cochlea. Input-output curves and amplitude-frequency curves were plotted before and after short exposures to intense noise. In addition to amplitude losses, important changes in the intensity functions result...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(84)90067-4
更新日期：1984-04-01 00:00:00
abstract：:Many hearing-impaired listeners struggle to localize sounds due to poor availability of binaural cues. Listeners with a cochlear implant and a contralateral hearing aid - so-called bimodal listeners - are amongst the worst performers, as both interaural time and level differences are poorly transmitted. We present a n...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.03.007
更新日期：2018-06-01 00:00:00
abstract：:Auditory brainstem implants (ABIs) can restore useful hearing to persons with deafness who cannot benefit from cochlear implants. However, the quality of hearing restored by ABIs rarely is comparable to that provided by cochlear implants in persons for whom those are appropriate. In an animal model, we evaluated eleme...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.03.009
更新日期：2018-06-01 00:00:00
abstract：:Recordings were made from 185 neurons in the primary auditory cortex of cats in the age range of 15 to 297 days. A comparison was made between the tuning for click repetition-rate and for amplitude modulation-frequency of a noise burst on the basis of temporal Modulation Transfer Functions (tMTF). 90 of the 185 units ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90212-j
更新日期：1993-02-01 00:00:00
abstract：:The human fetal auditory system is functional around the 25th week of gestational age when the thalamocortical connections are established. Fetal magnetoencephalography (fMEG) provides evidence for fetal auditory brain responses to pure tones and syllables. Fifty-five pregnant women between 31 and 40 weeks of gestatio...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.03.005
更新日期：2018-06-01 00:00:00
abstract：:Owing to the advances in transgenic animal technology and the advent of the next-generation sequencing era, over 120 genes causing hereditary hearing loss have been identified by now. In parallel, the field of human gene therapy continues to make exciting and rapid progress, culminating in the recent approval of sever...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2020.108092
更新日期：2020-10-15 00:00:00
abstract：:The f2-f1 distortion product otoacoustic emission (DPOAE) can be observed to undergo gradual alterations in amplitude during continuous ipsilateral stimulation with primary tones. In the present experiments, we characterized the dependence of these amplitude alterations on several stimulus variables (intensity, durati...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00041-2
更新日期：1995-05-01 00:00:00
abstract：:Intracellular recordings were made from both inner and outer hair cells (IHC, OHC) in the basal coil of the guinea pig cochlea before, during and after the animal was exposed to loud, pure tones. Following multiple loud tones both types of sensory cells demonstrate a culmulative decrease in their voltage responses to ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(88)90040-8
更新日期：1988-09-01 00:00:00
abstract：:Normotensive and spontaneously hypertensive rats (SHRs) were given arterial infusions of saline and pentoxifylline in doses of 1.5, 2.0, and 3.0 mg/kg/min. Blood pressure decreased in a dose related fashion with increasing doses of pentoxifylline. Cochlear blood flow, measured via laser Doppler flowmeter, increased wi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(88)90059-7
更新日期：1988-11-01 00:00:00
abstract：:Temperature sensitive auditory neuropathy is a very rare and puzzling disorder. In the present study, we reported three unrelated 2 to 6 year-old children who were diagnosed as auditory neuropathy patients who complained of severe hearing loss when they had fever. Their hearing thresholds varied from the morning to th...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.01.008
更新日期：2016-05-01 00:00:00
