Abstract：
:Chronic ischemic heart disease patients are already being treated worldwide with bone marrow stem cells both in the context of clinical studies and in therapy trials. By combining this therapy with established revascularization procedures such as bypass surgery, a high level of patient safety can be achieved. To date, no stem cell-related cardiac complications following intramyocardial injection of bone marrow-derived stem cells during CABG (coronary artery bypass graft) surgery have been reported. The functional advantage conferred by surgical bone marrow stem cell therapy is a 7.2% increase in LVEF (left ventricular ejection fraction) compared to controls. Randomized placebo-controlled trials, like the German trial PERFECT, are needed to obtain a more evidence-based assessment of this therapy.
journal_name
Herzjournal_title
Herzauthors
Kaminski A,Donndorf P,Klopsch C,Steinhoff Gdoi
10.1007/s00059-010-3354-ysubject
Has Abstractpub_date
2010-08-01 00:00:00pages
324-33issue
5eissn
0340-9937issn
1615-6692journal_volume
35pub_type
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