Abstract：
INTRODUCTION:Although it is known that female rats have a more robust behavioral response to acute cocaine administration than male rats, the neurobiological mechanisms underlying these differences remain unclear. The purpose of the present study was to determine if there are sex differences in cocaine's regulation of dopamine D1 and D2 receptor mRNA levels. METHODS:Male and female Fischer rats received acute cocaine (20 mg/kg, intraperitoneal) or saline. Ambulatory activity was recorded one hour post drug treatment. Rats were then sacrificed either 1 or 24 hours post drug treatment and D1/D2 DA receptor mRNA levels were measured via solution hybridization assay. RESULTS:Cocaine-induced ambulatory activity was greater in female than male rats. There were no sex differences in baseline levels of D1 and D2 receptor mRNA in the caudate putamen (CPu) or the nucleus accumbens (NAc). Cocaine administration reduced levels of D1 mRNA in the NAc only in male rats. CONCLUSION:Our findings suggest that the regulation of striatal D1 mRNA levels after acute cocaine administration is a sexually dimorphic process. We also hypothesize that the D1 receptor may be an important substrate in the regulation of sex differences in cocaine-induced locomotor activity.
journal_name
Ethn Disjournal_title
Ethnicity & diseaseauthors
Festa ED,Shivers KY,Jenab S,Quiñones-Jenab Vsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
S1-24-7issue
1 Suppl 1eissn
1049-510Xissn
1945-0826journal_volume
20pub_type
杂志文章abstract：BACKGROUND:The objective was to investigate how data on race and ethnicity are collected by hospitals reporting to the New Hampshire State Cancer Registry (NHSCR). METHOD:NHSCR surveyed hospitals asking how information on race and ethnicity were collected. A review of relevant legal mandates and national guidelines wa...
journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:The current study examined ethnic differences in patterns of weight loss and regain in response to an initial behavioral weight loss intervention followed by an extended-care maintenance program. METHODS:We analyzed data from 224 women (African American n = 43, Caucasian n = 181) from rural communities who p...
journal_title：Ethnicity & disease
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Lipid levels, including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides, have been reported to be associated with breast cancer risk. METHODS:We studied African American women (97 breast cancer cases and 102 controls) accrued through a population-...
journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVE:In a cross-sectional study, we examined the association between hyperinsulinemia and hypertension, independent of body mass, among White non-Hispanic, Black non-Hispanic, and Mexican-American adults without diabetes. METHODS:Data are from 8,004 adults, aged > or = 20 years from the Third National Health and ...
journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
更新日期：2002-04-01 00:00:00
abstract：:There are well-known Black-White disparities in adverse birth outcomes, health behaviors, and chronic diseases such as asthma, diabetes, and hypertension. These disparities hold across socioeconomic status and have remained stable for the past 50 years despite efforts to reduce them. This theoretical review argues tha...
journal_title：Ethnicity & disease
pub_type： 杂志文章,评审
doi：
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:To determine the effects of baseline cognitive function on incidence of disability in activities of daily living (ADL) in initially non-disabled Mexican-American elderly over a 7-year period. DESIGN:A prospective cohort study. SETTING:Southwestern United States: Texas, California, Arizona, New Mexico, and C...
journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:The purpose of the present study was to examine variation in heart disease death rates by the social class of decedents. The term, "social class" refers to a complex set of phenomena such as control over economic resources, social status, and power relative to others in society. The target population for this study wa...
journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
更新日期：2002-10-01 00:00:00
abstract：OBJECTIVE:This study examined geographic variation in incidence rates for two cancers common in US Hispanic women and considered some potential explanations, by using data from several high-quality cancer registries. METHODS:Age-standardized incidence rates (ASIRs) per 100,000 Hispanic women per year were analyzed for...
journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
更新日期：2005-10-01 00:00:00
abstract：OBJECTIVE:This study evaluates patient inertia (PtInert) factors including hopelessness in African Americans participating in church cardiovascular screening programs in low income areas in Forsyth County, North Carolina. Patient inertia is defined as an inability to assume adequate hypertension self-management behavio...
journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:An estimated 1.2 billion citizens of the world are smokers. In developing countries, half the males smoke. WHO projects a global smoking population of 1.6 billion by the end of the next two decades. Collectively, today the world's smokers annually consume nearly 1,000 cigarettes for every man, woman and child on the p...
journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
更新日期：2007-07-01 00:00:00
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journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：10.18865/ed.30.4.603
更新日期：2020-09-24 00:00:00
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journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
更新日期：2011-04-01 00:00:00
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journal_title：Ethnicity & disease
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
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journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
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journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
更新日期：2008-04-01 00:00:00
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journal_title：Ethnicity & disease
pub_type： 杂志文章
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journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
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journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
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journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
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journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
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journal_title：Ethnicity & disease
pub_type： 杂志文章,评审
doi：
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journal_title：Ethnicity & disease
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journal_title：Ethnicity & disease
pub_type： 杂志文章
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journal_title：Ethnicity & disease
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Ethnicity & disease
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更新日期：1996-10-01 00:00:00
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journal_title：Ethnicity & disease
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journal_title：Ethnicity & disease
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