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Impact of guided bone regeneration and defect dimension on wound healing at chemically modified hydrophilic titanium implant surfaces: an experimental study in dogs.

Abstract：

OBJECTIVES:The aim of the present study was to evaluate the impact of guided bone regeneration and defect dimension on wound healing at chemically modified titanium implant surfaces (modSLA). MATERIALS AND METHODS:ModSLA implants were placed at chronic-type lateral ridge defects of different heights (H1-H4: 2, 4, 6 and 8 mm) and randomly allocated to either (a) GBR (polyethylene glycol membrane + biphasic calcium phosphate) or (b) untreated control. At 2 and 8 weeks (n=6 dogs each), dissected blocks were processed for histomorphometrical analysis [e.g., percentage linear fill (PLF), regenerated area (RA)]. RESULTS:At 8 weeks, both groups revealed comparable mean PLF (%) [ CONTROL:H1 (26.1 +/- 5.8)-H4 (60.4 +/- 11.8); GBR: H1 (8.3 +/- 5.3)-H4 (50.7 +/- 23.1)] and RA (mm(2)) [ CONTROL:H1 (2.5 +/- 0.4)-H4 (7.4 +/- 4.1); GBR: H1 (1.8 +/- 1.0)-H4 (10.8 +/- 5.9)] values. A significant difference was observed for the mean PLF values at H1 defects. CONCLUSION:It was concluded that (i) modSLA titanium implants supported bone regeneration and osseointegration at H1-H4 defects and (ii) the present GBR procedure did not seem to improve the outcome of vertical bone regeneration, but tended to increase the mean RA values.

journal_name

J Clin Periodontol

journal_title

Journal of clinical periodontology

authors

Schwarz F,Jung RE,Fienitz T,Wieland M,Becker J,Sager M

doi

10.1111/j.1600-051X.2010.01551.x

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

474-85

issue

5

eissn

0303-6979

issn

1600-051X

pii

CPE1551

journal_volume

37

pub_type

杂志文章

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