Generating and confirming hypotheses.

abstract：PURPOSE:To determine prescribing patterns by general physicians working in primary care (GPs) in Iran for the elderly and the prevalence of inappropriate prescribing. METHODS:We collected information about prescribed medicines for 10% of patients in primary care aged 65 years or above in six cities in one province dur...

journal_title：Pharmacoepidemiology and drug safety

authors： Ghadimi H,Esmaily HM,Wahlstrom R

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:We conducted a nested case-control study to evaluate the association between risk of cancer and mirtazapine use in depression patients in Taiwan. METHODS:We obtained data from the Taiwan National Health Insurance Research Database to conduct a population-based nested case-control study. The study cohort includ...

journal_title：Pharmacoepidemiology and drug safety

authors： Sun LM,Lin MC,Liang JA,Chang YJ,Chang SN,Sung FC,Muo CH,Kao CH

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:Estimating drug effectiveness and safety among older adults in population-based studies using administrative health care claims can be hampered by unmeasured confounding as a result of frailty. A claims-based algorithm that identifies patients likely to be dependent, a proxy for frailty, may improve confounding...

journal_title：Pharmacoepidemiology and drug safety

authors： Faurot KR,Jonsson Funk M,Pate V,Brookhart MA,Patrick A,Hanson LC,Castillo WC,Stürmer T

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To assess the pattern of in-hospital changes in drug use in older patients from 2010 to 2016. METHODS:People aged 65 years or more acutely hospitalized in those internal medicine and geriatric wards that did continuously participate to the REgistro POliterapie Società Italiana di Medicina Interna register from...

journal_title：Pharmacoepidemiology and drug safety

authors： Franchi C,Ardoino I,Nobili A,Pasina L,Mannucci PM,Marengoni A,Perticone F,REPOSI investigators.

更新日期：2017-12-01 00:00:00

abstract：:Pharmaceutical manufacturers are faced with the challenge of when and how to conduct pharmacoeconomic (PE) evaluations to satisfy formulary decision-makers. To illustrate the usefulness of decision analysis for strategic planning in drug development, a model was created to compare the cost-benefit of three PE design o...

journal_title：Pharmacoepidemiology and drug safety

authors： Ungar W

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:Outcome misclassification may occur in observational studies using administrative databases. We evaluated a two-step multiple imputation approach based on complementary internal validation data obtained from two subsamples of study participants to reduce bias in hazard ratio (HR) estimates in Cox regressions....

journal_title：Pharmacoepidemiology and drug safety

authors： Ni J,Leong A,Dasgupta K,Rahme E

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:Medicaid programs are concerned about inappropriate, potentially hazardous, and costly off-label use of second-generation antipsychotics (SGAs). Several states are exploring policies aimed at managing low-dose quetiapine, commonly prescribed for off-label conditions. This study aimed to characterize longitudina...

journal_title：Pharmacoepidemiology and drug safety

authors： Hartung DM,Zerzan J,Yamashita T,Tong S,Morden NE,Libby AM

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Antiepileptic drugs (AEDs) are also prescribed for therapeutic indications other than epilepsy (EPI), namely, psychiatric disorders (PSY). Our aim was to develop an algorithm able to distinguish between EPI and PSY among childbearing age women based on differences in AED exposure in these patient groups. ME...

journal_title：Pharmacoepidemiology and drug safety

authors： Naldi I,Piccinni C,Mostacci B,Renzini J,Accetta G,Bisulli F,Tappatà M,Piazza A,Pagano P,Bianchi S,D'Alessandro R,Tinuper P,Poluzzi E,ESPEA (Emilia-Romagna Study on Pregnancy and Exposure to Antiepileptic drugs) Group.

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:We aimed to investigate the association between psychotropic treatment and risk of burn injury in individuals with mental illness. METHODS:A nested case-control study was conducted by using the National Health Insurance Research Database in Taiwan. A total of 3187 cases with burn injury under International Cla...

journal_title：Pharmacoepidemiology and drug safety

authors： Chang CM,Wu KY,Chiu YW,Wu HT,Tsai YT,Chau YL,Tsai HJ

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:Our study aimed to investigate the association between prenatal exposure to reactive intermediate (RI)-inducing drugs and the initiation of psychotropic medications among children. METHODS:We designed a cohort study using a pharmacy prescription database. Pregnant women were considered exposed when they receiv...

journal_title：Pharmacoepidemiology and drug safety

authors： Tran YH,Groen H,Bergman JE,Hak E,Wilffert B

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Determination of the incidence rate of diabetic ketoacidosis (DKA) in type 2 diabetes mellitus (T2DM) is urgent, in response to the safety issue with use of the glucose lowering drugs, sodium-glucose cotransporter-2 inhibitors, and DKA. METHODS:We extracted data of adult patients with T2DM from a medical claim...

journal_title：Pharmacoepidemiology and drug safety

authors： Takeuchi M,Kawamura T,Sato I,Kawakami K

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Long-term benzodiazepine (BZD) treatment continues to be a debated topic. Because individual BZDs have different clinical profiles, we assessed the nationwide trends of long-term BZD use at active substance level during years 2006 to 2014. METHODS:This study covered all reimbursed BZD purchases (n = 408 572-52...

journal_title：Pharmacoepidemiology and drug safety

authors： Kurko T,Saastamoinen LK,Tuulio-Henriksson A,Taiminen T,Tiihonen J,Airaksinen M,Hietala J

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:To characterize the nature of a heparin contaminant's clinical effects in cases reported to the Adverse Event Reporting System (AERS). The FDA received reports of heparin-associated adverse events (AEs) starting in late 2007-early 2008 during a national investigation of allergic-type events. The investigation i...

journal_title：Pharmacoepidemiology and drug safety

authors： McMahon AW,Pratt RG,Hammad TA,Kozlowski S,Zhou E,Lu S,Kulick CG,Mallick T,Dal Pan G

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:To evaluate the outcomes of patients participating in a program of integrated care for osteoporosis in terms of medication supply, fracture incidence and expenses. METHODS:Outcomes were assessed from secondary data provided by the AOK PLUS health insurance for 2455 participants of the program and the same numb...

journal_title：Pharmacoepidemiology and drug safety

authors： Goltz L,Degenhardt G,Maywald U,Kirch W,Schindler C

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:To determine the prevalence of purchase of prescribed antihypertensive and/or serum lipid-reducing pharmaceutical preparations among different age groups, from the age of 45, in the Swedish population. Further, to calculate the percentage of the population, from the age of 60, who purchased these pharmaceutical...

journal_title：Pharmacoepidemiology and drug safety

authors： Silwer L,Lundborg CS,Petzold M

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:The General Practice Research Database (GPRD) is a database of longitudinal patient records from general practices in the United Kingdom. It is an important data source for pharmacoepidemiology studies, but until now it has been tedious to calculate the daily dose and duration of exposure to drugs prescribed. T...

journal_title：Pharmacoepidemiology and drug safety

authors： Shah AD,Martinez C

更新日期：2006-03-01 00:00:00

abstract：:It is surprising to see how consumer Adverse Drug Reaction (ADR) reports have been continuously increasing for the last few years in Europe. This probably results from the influence of United States (US) market where the patients feels justified in telephoning the pharmaceutical companies directly with queries regardi...

journal_title：Pharmacoepidemiology and drug safety

authors： Fleuranceau-Morel P

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:In pharmacoepidemiology, one of the main concerns is analysis of drug exposure time. However, in real-life settings, patient's behavior is complex and characterized by drug exposure dynamics. Multi-state models allow assessing the probabilities of various patterns, instead of just continuous use and/or disconti...

journal_title：Pharmacoepidemiology and drug safety

authors： Boucherie Q,Pauly V,Frauger E,Thirion X,Pradel V,Micallef J

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:This study examined recent trends and correlates of prescription opioid use and long-term use in the United States. METHODS:Data were from 47 356 adult participants of National Health and Nutrition Survey from 1999-2000 to 2013-2014. Participants were asked about prescription medications used in the past 30 da...

journal_title：Pharmacoepidemiology and drug safety

authors： Mojtabai R

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:Economic factors, market dynamics, and safety issues are largely responsible for decisions to withdraw pharmaceutical products from the market. In this study, new molecular entities (NMEs) approved by the Food and Drug Administration (FDA) were examined in the USA from 1980 to 2009. METHODS:Data were obtained ...

journal_title：Pharmacoepidemiology and drug safety

authors： Qureshi ZP,Seoane-Vazquez E,Rodriguez-Monguio R,Stevenson KB,Szeinbach SL

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:To examine the association between maternal use of beta-2-adrenergic agonists (β2AAs) and the risk of epilepsy in offspring. METHODS:A nationwide retrospective cohort study was performed based on Danish registries. Children of mothers who used β2AAs during pregnancy were allocated to the exposed group and othe...

journal_title：Pharmacoepidemiology and drug safety

authors： Chen J,Liang H,Miao M,Su X,Yang F,Thomsen RW,Yuan W,Li J

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Bayesian hierarchical models (BHMs) have been used to identify adverse drug reactions, allowing information sharing amongst adverse reactions and drugs expected to have similar properties. This study evaluated the use of BHMs in the routine signal detection analyses of potential first-trimester teratogens, wher...

journal_title：Pharmacoepidemiology and drug safety

authors： Cavadino A,Prieto-Merino D,Morris JK

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:The use of granulocyte colony-stimulating factor (G-CSF) in the treatment of non-chemotherapy drug- induced agranulocytosis is controversial. We aimed at assessing the effect of G-CSF on the duration of agranulocytosis. METHODS:To assess the effect of G-CSF on the duration of agranulocytosis, a Cox proportiona...

journal_title：Pharmacoepidemiology and drug safety

authors： Ibáñez L,Sabaté M,Ballarín E,Puig R,Vidal X,Laporte JR,Agranulocytosis and Aplastic Anaemia Study Group of Barcelona.

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:Clinical trials of olmesartan for prevention of progression of renal disease in patients with diabetes showed renal protection but an unexpected imbalance in cardiac deaths. The US Food and Drug Administration requested from the manufacturer a cohort study of olmesartan, other angiotensin-receptor blockers (ARB...

journal_title：Pharmacoepidemiology and drug safety

authors： Walker AM,Liang C,Clifford CR,Parker C,Feldman A

更新日期：2014-04-01 00:00:00

abstract：PURPOSE:This study evaluated the safety of oseltamivir during the 2009 influenza pandemic. METHODS:Case reports were obtained from the Roche safety database. The incidence of adverse events (AEs) during the pandemic (1 May 2009 to 31 December 2009) was compared with that beforehand (during previous influenza seasons) ...

journal_title：Pharmacoepidemiology and drug safety

authors： Donner B,Bader-Weder S,Schwarz R,Peng MM,Smith JR,Niranjan V

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:Innovative methods are needed to assess risks related to treatment for common medical conditions, where therapy is usually patient-directed or over-the-counter (OTC), and where tolerability, i.e. patient experienced events, may affect patterns of use. A large-scale, blinded, randomised trial was conducted to co...

journal_title：Pharmacoepidemiology and drug safety

authors： Van Ganse E,Jones JK,Moore N,Parc JM,Wall R,Schneid H

更新日期：2005-04-01 00:00:00

abstract：:Before a medicine can be recommended for a marketing authorization research must be provided to regulators that convincingly supports the benefit-risk of the product in the claimed indication. The established criteria for such research are usually expressed in terms of evidence from randomized controlled trials (RCT)....

journal_title：Pharmacoepidemiology and drug safety

authors： Slattery J,Kurz X

更新日期：2020-10-01 00:00:00

abstract：AIM:To study the influence of media attention about statins and ADRs on the level of disproportionality, expressed as the reporting odds ratio (ROR) for statins in the Lareb database, based on patients' reports. METHODS:Patient reports about statins, before and after the broadcast of a consumer programme about statins...

journal_title：Pharmacoepidemiology and drug safety

authors： van Hunsel F,van Puijenbroek E,de Jong-van den Berg L,van Grootheest K

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:Community Pharmacists both have an important responsibility in monitoring the ongoing safety of medicines and are widely accessible to do it. This study aims to investigate the knowledge, perceptions and practice of Pharmacovigilance amongst community pharmacists in Lagos State, South West Nigeria METHODS:A cr...

journal_title：Pharmacoepidemiology and drug safety

authors： Oreagba IA,Ogunleye OJ,Olayemi SO

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:The objective of this study was to determine the fraction of variance in patient-level medication adherence accounted for by prescribers and pharmacies. METHODS:We used prescription drug claims paid between January 2010 and July 2011 to a national pharmacy benefits manager to define implementation during persi...

journal_title：Pharmacoepidemiology and drug safety

authors： Genberg BL,Rogers WH,Lee Y,Qato DM,Dore DD,Hutchins DS,Brennan T,Matlin OS,Wilson IB

更新日期：2016-07-01 00:00:00