Abstract：
:A tribal aboriginal community, the Mowanjum, from the Kimberley region in Western Australia has been screened to determine the extent of genetic variation in the products of genes coding for apolipoproteins, which are intimately involved in lipid metabolism. Of the seven systems tested, APOE and APOH revealed common structural variations, but their distribution patterns are significantly different from those found in European populations. Australian Aborigines were found to be unique because they have no APOE*2 and APOH*3 alleles and have strikingly high frequencies of the APOE*4 (26%) and APOH*1 (13%) alleles. The contrast in variation observed at these apolipoprotein loci between Australian Aborigines and Europeans not only makes these loci useful genetic markers in biologic anthropology studies but also provides a unique opportunity to investigate the role of genetic-environment interaction in determining interpopulation differences in cardiovascular disease risk factors.
journal_name
Hum Bioljournal_title
Human biologyauthors
Kamboh MI,Serjeantson SW,Ferrell REsubject
Has Abstractpub_date
1991-04-01 00:00:00pages
179-86issue
2eissn
0018-7143issn
1534-6617journal_volume
63pub_type
杂志文章相关文献
HUMAN BIOLOGY文献大全abstract：:This address is a tribute to a pioneer of population genetics, including human population genetics. The unique methodology employed by Sewall Wright in many genetic problems is the method of path coefficients. This essay traces the historical landmarks in the development of the path method and then shows how some of t...
journal_title：Human biology
pub_type： 历史文章,杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：:The radical improvement in living conditions experienced in Italy during the last century caused a reduction in male extra-mortality during the prereproductive years. As a consequence, a progressive increase in the sex ratio at the beginning of the reproductive age (15-19 years) occurred, so that in recent times the s...
journal_title：Human biology
pub_type： 杂志文章
doi：10.1353/hub.2001.0014
更新日期：2001-02-01 00:00:00
abstract：:We studied 3925 individuals in 961 families to determine the mode of inheritance of overweight. As an index of overweight, we examined body mass index. Our analyses indicate that the most likely genetic model for susceptibility to overweight included moderate polygenic inheritance (34% of variance resulting from many ...
journal_title：Human biology
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：:Previous studies have sought to associate the Pro12Ala variant of the peroxisome proliferator-activated receptor gamma2 (PPARG2) gene with type 2 diabetes, insulin resistance, and obesity, with controversial results. We have determined the Pro12Ala variant frequency in 370 nondiabetic Mexican Mestizo subjects and in f...
journal_title：Human biology
pub_type： 杂志文章,多中心研究
doi：10.1353/hub.2007.0022
更新日期：2007-02-01 00:00:00
abstract：:Although much attention has been given to statistical genetic methods for the initial localization and fine mapping of quantitative trait loci (QTLs), little methodological work has been done to date on the problem of statistically identifying the most likely functional polymorphisms using sequence data. In this paper...
journal_title：Human biology
pub_type： 杂志文章
doi：10.1353/hub.2006.0003
更新日期：2005-10-01 00:00:00
abstract：:Although scattered throughout a large geographic area, the members of the Pano linguistic group present strong ethnic, linguistic, and cultural homogeneity, a feature that causes them to be considered components of a same "Pano" tribe. Nevertheless, the genetic homogeneity between Pano villages has not yet been examin...
journal_title：Human biology
pub_type： 杂志文章
doi：10.3378/027.086.0203
更新日期：2014-04-01 00:00:00
abstract：:The fertility pattern, in terms of birth intervals, in a rural population not practicing contraception belonging to La Alta Alpujarra Oriental (southeast Spain) is analyzed. During the first half of the 20th century, this population experienced a considerable degree of geographical and cultural isolation. Because of t...
journal_title：Human biology
pub_type： 杂志文章
doi：
更新日期：2000-10-01 00:00:00
abstract：:Mutations in the GJB2 gene are a major cause of congenital deafness. One specific mutation, the 35delG mutation, has accounted for most of the GJB2 mutations detected in European populations and is one of the most frequent disease mutations identified so far. We evaluated the frequency of the 35delG mutation in DNA sa...
journal_title：Human biology
pub_type： 杂志文章
doi：10.1353/hub.2004.0035
更新日期：2004-04-01 00:00:00
abstract：:We compared the global pattern of variation at two homologous microsatellites mapping to the long arm of the X chromosome (DXYS156X) and to the short arm of the Y chromosome (DXYS156Y) in humans. A single pair of oligonucleotide primers amplifies these two nonallelic loci, each of which contains polymorphism in the nu...
journal_title：Human biology
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:The Norse and Celtic contributions to the founding population of Iceland have been estimated previously on a pan-Icelandic basis using gene frequency data for the entire island. Accounts of the settlement of Iceland, however, suggest that different regions received different proportions of Norse and Celtic settlers, i...
journal_title：Human biology
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:While discriminant function analysis is an inherently Bayesian method, researchers attempting to estimate ancestry in human skeletal samples often follow discriminant function analysis with the calculation of frequentist-based typicalities for assigning group membership. Such an approach is problematic because it fail...
journal_title：Human biology
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
abstract：:Cytochrome 1A1 (CYP1A1), glutathione transferase M1 (GSTM1), and glutathione transferase T1 (GSTT1) catalyze the bioactivation and detoxification of a wide variety of xenobiotic compounds that are mutagenic and/or carcinogenic (e.g., polycyclic aromatic hydrocarbons). Genetic polymorphisms of these metabolizing enzyme...
journal_title：Human biology
pub_type： 杂志文章
doi：10.3378/1534-6617-80.4.457
更新日期：2008-08-01 00:00:00
abstract：:We investigated differential sex-biased parental investment in relation to social status in 59 Kavango males from Rundu, the administrative and commercial center of the Kavango district in northern Namibia, and in 78 Kavango males from the rural areas around Rundu. Twenty-three body dimensions were used as indicators ...
journal_title：Human biology
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：:We analyze the possible effect of gene flow on the genetic structure of present-day Mexicans. For this purpose we reviewed previous admixture estimates for various Indian and Mestizo groups. Several facts seem clear: (1) There are no pure Indian groups in Mexico, because all Indian groups show variable degrees of admi...
journal_title：Human biology
pub_type： 杂志文章,多中心研究
doi：
更新日期：1996-06-01 00:00:00
abstract：:Twelve healthy, anal-receptive, homosexual Caucasian males who were seronegative for HIV antibody were typed for HLA-DR antigens. Flow cytometry was used to immunophenotype peripheral blood lymphocytes bearing the CD4, CD8, LEU7, and combined CD8 and LEU7 antigens. These individuals had reported a large number of sexu...
journal_title：Human biology
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：:The primary purpose of this research is to collate, compare, and discuss the presently available data for head and face dimensions among Korean and Japanese ethnic groups. Classification of Korean male and female head and face types is simpler than classification of Japanese subjects. Male groups have more statistical...
journal_title：Human biology
pub_type： 杂志文章
doi：10.3378/1534-6617-80.3.313
更新日期：2008-06-01 00:00:00
abstract：:The genetic surveys of the population of Britain conducted by Weale et al. and Capelli et al. produced estimates of the Germani immigration into Britain during the early Anglo-Saxon period, c.430-c.730. These estimates are considerably higher than the estimates of archaeologists. A possible explanation suggests that a...
journal_title：Human biology
pub_type： 历史文章,杂志文章
doi：10.3378/027.083.0604
更新日期：2011-12-01 00:00:00
abstract：:There is widespread interest in obtaining genetic samples from human populations worldwide for various studies of human genetic diversity. Many samples exist today only in the form of small, rare, irreplaceable, or archival samples, such as material from ancient bone, hair bulbs, or remnants of samples collected in th...
journal_title：Human biology
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:The present study reports the genetic variation observed among five anthropologically distinct population groups of India, using four highly polymorphic minisatellite loci (D1S80, D17S5, D19S20, and APOB 3' VNTR) in order to examine the effect of geographical and linguistic affiliations on the genetic affinities among...
journal_title：Human biology
pub_type： 杂志文章
doi：10.1353/hub.2002.0028
更新日期：2002-06-01 00:00:00
abstract：:It was predicted that at the state level early neonatal (0-6 days) mortality rates and rates for sudden infant death syndrome (SIDS) in the age range 7-364 days would be negatively correlated. Using published data for each of the 50 states and the District of Columbia over the 5-year period 1980-1984, the actual corre...
journal_title：Human biology
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:This article deals with the problem of the causes of the variation of sex ratio (proportion male) at birth. This problem is common to a number of areas in biology and medicine, for example, obstetrics, neurology/psychiatry, parasitology, virology, oncology, and teratology. It is established that there are signifi cant...
journal_title：Human biology
pub_type： 杂志文章,评审
doi：10.3378/027.085.0513
更新日期：2013-10-01 00:00:00
abstract：:We investigated the relationship between the dispersal potential of a hominin population, its local-scale foraging strategies, and the characteristics of the resource environment using an agent-based modeling approach. In previous work we demonstrated that natural selection can favor a relatively low capacity for asse...
journal_title：Human biology
pub_type： 杂志文章
doi：10.13110/humanbiology.87.3.0205
更新日期：2015-07-01 00:00:00
abstract：:The polymorphism of human mitochondrial DNA (mtDNA) was studied in 118 unrelated Greeks (from northern Greece) using total blood cell DNA and the restriction enzymes HpaI, BamHI, HaeII, MspI, AvaII, and HincII. One new morph was identified for MspI (named MspI morph 18Gr) and is the result of a mutation in a previousl...
journal_title：Human biology
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:The 657del5 mutation of the NBS1 gene has been demonstrated in most patients with Nijmegen breakage syndrome (NBS). We identified four Turkish families in which probands were diagnosed as having NBS and found to be homozygous for the 657del5 mutation. The 657del5 allele in the four Turkish families had a single origin...
journal_title：Human biology
pub_type： 杂志文章
doi：10.1353/hub.2005.0056
更新日期：2005-06-01 00:00:00
abstract：:The coefficient of relationship by isonymy Ri is a good indicator of similarities between and within populations by means of identity of surnames. In this study we present the results of an analysis of Ri obtained using two surnames for each person in two small Venezuelan populations of African origin: Birongo and La ...
journal_title：Human biology
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:Low-molecular-weight acid phosphatase (ACP1) is a polymorphic protein-tyrosine phosphatase present in all human tissues, including adipocytes. A positive association between the low-activity ACP1*A/*A genotype and extreme body mass index has previously been shown by us in obese subjects from the population of Rome. We...
journal_title：Human biology
pub_type： 杂志文章
doi：
更新日期：1997-08-01 00:00:00
abstract：:Eight STR systems (THO1, FABP, VWA, FES/FPS, HPRTB, F13A1, CSF1PO, and D6S366) were investigated in different ethnic groups of Argentina. Allele and genotype frequencies, power of exclusion, and discriminative power were investigated. Hardy-Weinberg expectations were calculated from heterozygosity levels. FST and G te...
journal_title：Human biology
pub_type： 杂志文章
doi：
更新日期：1998-10-01 00:00:00
abstract：:Lipoprotein lipase (LPL) plays a critical role in the metabolism of lipoproteins because this enzyme hydrolyzes the triacylglycerides in chylomicrons and very low density lipoproteins. This process influences the production of high-density lipoprotein (HDL), which takes up tissue cholesterol for transport to the liver...
journal_title：Human biology
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:We have investigated the clinical, hematological, and molecular genetic characteristics of sickle cell anemia patients from 6 populations of Andhra Pradesh, South India. Of 72 sickle cell chromosomes (HBB*S) 60 belong to characteristic Arab-Indian haplotypes, 6 to variant Arab-Indian haplotypes, 1 to a Bantu haplotype...
journal_title：Human biology
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
abstract：:Involvement of genetic factors in determining bone mineral density (BMD) is doubtless. However, the exact nature of the genes governing BMD variation and sources for genetic determination of BMD of different parts of bone (compact and cancellous) have not been completely studied. The results of the complex segregation...
journal_title：Human biology
pub_type： 杂志文章
doi：
更新日期：1999-04-01 00:00:00
