Common major gene inheritance of extreme overweight.

Abstract:

:We studied 3925 individuals in 961 families to determine the mode of inheritance of overweight. As an index of overweight, we examined body mass index. Our analyses indicate that the most likely genetic model for susceptibility to overweight included moderate polygenic inheritance (34% of variance resulting from many genes with small effects) and common (21% frequency) recessively expressed major genes (a few genes with large effects on the individuals who possess them). Standard statistical criteria for accepting both polygenic and major gene inheritance were met, including tests of Mendelian transmission. These results suggest that recessive major gene inheritance of overweight may be common and that homozygosity for overweight susceptibility alleles often results in overweight. Clinical, biologic, and empirical observations all suggest genetic heterogeneity, that is, more than one predisposing gene.

journal_name

Hum Biol

journal_title

Human biology

authors

Price RA,Ness R,Laskarzewski P

subject

Has Abstract

pub_date

1990-12-01 00:00:00

pages

747-65

issue

6

eissn

0018-7143

issn

1534-6617

journal_volume

62

pub_type

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