Abstract：
:Mood disorders are highly heritable and have been linked to brain regions of emotion processing. Over the past few years, an enormous amount of imaging genetics studies has demonstrated the impact of risk genes on brain regions and systems of emotion processing in vivo in healthy subjects as well as in mood disorder patients. While sufficient evidence already exists for several monaminergic genes as well as for a few non-monoaminergic genes, such as brain-derived neurotrophic factor (BDNF) in healthy subjects, many others only have been investigated in single studies so far. Apart from these studies, the present review also covers imaging genetics studies applying more complex genetic disease models of mood disorders, such as epistasis and gene-environment interactions, and their impact on brain systems of emotion processing. This review attempts to provide a comprehensive overview of the rapidly growing field of imaging genetics studies in mood disorder research.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Scharinger C,Rabl U,Sitte HH,Pezawas Ldoi
10.1016/j.neuroimage.2010.02.019subject
Has Abstractpub_date
2010-11-15 00:00:00pages
810-21issue
3eissn
1053-8119issn
1095-9572pii
S1053-8119(10)00187-4journal_volume
53pub_type
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