Abstract:
:Near-infrared spectroscopy (NIRS) studies have reported that prefrontal hemodynamic dysfunction during executive function tasks may be a promising biomarker of psychiatric disorders, because its portability and noninvasiveness allow easy measurements in clinical settings. Here, we investigated the degree to which prefrontal NIRS signals are genetically determined. Using a 52-channel NIRS system, we monitored the oxy-hemoglobin (oxy-Hb) signal changes in 38 adult pairs of right-handed monozygotic (MZ) twins and 13 pairs of same-sex right-handed dizygotic (DZ) twins during a letter version of the verbal fluency task. Heritability was estimated based on a classical twin paradigm using structured equation modeling. Significant genetic influences were estimated in the right dorsolateral prefrontal cortex and left frontal pole. The degrees of heritability were 66% and 75% in the variances, respectively. This implies that the prefrontal hemodynamic dysfunction observed during an executive function task measured by NIRS may be an efficient endophenotype for large-scale imaging genetic studies in psychiatric disorders.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Sakakibara E,Takizawa R,Nishimura Y,Kawasaki S,Satomura Y,Kinoshita A,Koike S,Marumo K,Kinou M,Tochigi M,Nishida N,Tokunaga K,Eguchi S,Yamasaki S,Natsubori T,Iwashiro N,Inoue H,Takano Y,Takei K,Suga M,Yamasue H,doi
10.1016/j.neuroimage.2013.03.052subject
Has Abstractpub_date
2014-01-15 00:00:00pages
508-17eissn
1053-8119issn
1095-9572pii
S1053-8119(13)00302-9journal_volume
85 Pt 1pub_type
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