Abstract:
BACKGROUND:Nasopharyngeal carcinoma is a rare tumor entity in Switzerland. In contrast, it is endemic in Asian and African countries. Retrospective studies have been conducted in order to identify risk factors and prognostic determinants of nasopharyngeal carcinoma. Nonetheless, these trials were mostly conducted in regions with high prevalence for the disease and little is known about the risk factors and prognosis of nasopharyngeal carcinoma for a non-endemic population in Western Europe. METHODS:This retrospective trial was conducted to identify risk factors and prognostic determinants of nasopharyngeal carcinoma for a non-endemic population in Switzerland. RESULTS:Overall survival was 91%, 77% and 58% for one, three and five years, respectively. Factors with favourable prognostic value were concomitant radiochemotherapy regimens, photon radiotherapy, and a delay between diagnosis and first therapy session of less than ten weeks, respectively. Factors with unfavourable prognostic values were age over 65 years at time of diagnosis and nasopharyngeal carcinoma of WHO type I. CONCLUSION:Risk factors, biological behaviour and survival are well comparable between endemic and non-endemic populations for nasopharyngeal carcinoma. Nonetheless, an aggressive diagnostic procedure and sophisticated interdisciplinary therapy are indispensable in order to achieve favourable outcome. Therefore, diagnosis and therapy of nasopharyngeal carcinoma in non-endemic populations should be limited to highly specialized tertiary centres.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Sidler D,Thum P,Winterhalder R,Huber G,Haerle SKdoi
smw-12844subject
Has Abstractpub_date
2010-05-01 00:00:00pages
273-9issue
19-20eissn
1424-7860issn
1424-3997pii
smw-12844journal_volume
140pub_type
杂志文章abstract::Depending on the populations studied and the definitions applied, the prevalence of treatment-resistant hypertension varies from 10% to 15%, but is higher in conditions associated with increased sympathetic drive, such as obesity, obstructive sleep apnoea, diabetes or renal dysfunction. The Symplicity studies recently...
journal_title:Swiss medical weekly
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:smw-12425
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journal_title:Swiss medical weekly
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journal_title:Swiss medical weekly
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doi:2007/11/smw-11592
更新日期:2007-03-24 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14474
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doi:10.4414/smw.2015.14115
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doi:10.4414/smw.2011.13221
更新日期:2011-07-01 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:smw-11284
更新日期:2009-08-08 00:00:00
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doi:2002/25/smw-09972
更新日期:2002-06-29 00:00:00
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更新日期:2017-05-10 00:00:00
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更新日期:2012-02-03 00:00:00
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更新日期:2018-04-26 00:00:00
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doi:10.4414/smw.2010.13063
更新日期:2010-07-11 00:00:00
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pub_type: 杂志文章
doi:10.4414/smw.2011.13152
更新日期:2011-02-03 00:00:00
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doi:2007/45/smw-11697
更新日期:2007-11-17 00:00:00
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doi:10.4414/smw.2015.14206
更新日期:2015-12-04 00:00:00