Electrical dimensions in cell science.

abstract：:Notch signalling is used throughout the animal kingdom to spatially and temporally regulate cell fate, proliferation and differentiation. Its importance is reflected in the dramatic effects produced on both development and health by small variations in the strength of the Notch signal. The Down-syndrome-associated kin...

journal_title：Journal of cell science

authors： Fernandez-Martinez J,Vela EM,Tora-Ponsioen M,Ocaña OH,Nieto MA,Galceran J

更新日期：2009-05-15 00:00:00

abstract：:Enterotoxigenic Bacteroides fragilis - organisms that live in the colon - secrete a metalloprotease toxin, B. fragilis toxin. This toxin binds to a specific intestinal epithelial cell receptor and stimulates cell proliferation, which is dependent, in part, on E-cadherin degradation and beta-catenin-T-cell-factor nucle...

journal_title：Journal of cell science

authors： Wu S,Rhee KJ,Zhang M,Franco A,Sears CL

更新日期：2007-06-01 00:00:00

abstract：:The mechanism by which glutamate regulates the cytosolic free Ca2+ concentration ([Ca2+]c) in spontaneously firing dopamine neurons is not clear. Thus we have investigated the glutamate-mediated [Ca2+]c dynamics in the acutely isolated dopamine neurons from the rat substantia nigra pars compacta by measuring [Ca2+]c a...

journal_title：Journal of cell science

authors： Choi YM,Kim SH,Uhm DY,Park MK

更新日期：2003-07-01 00:00:00

abstract：:Neuronal morphology plays an essential role in neuronal function. The establishment and maintenance of neuronal morphology is intimately linked to the actin cytoskeleton; however, the molecular mechanisms that regulate changes in neuronal morphology are poorly understood. Here we identify a novel myosin-Va (MyoVa)-int...

journal_title：Journal of cell science

authors： Lisé MF,Srivastava DP,Arstikaitis P,Lett RL,Sheta R,Viswanathan V,Penzes P,O'Connor TP,El-Husseini A

更新日期：2009-10-15 00:00:00

abstract：:Although it is well established that embryonic stem (ES) cells have the potential to differentiate into dopamine neurons, the molecular basis of this process, particularly the role of microRNAs (miRNAs), remains largely unknown. Here we report that miR-132 plays a key role in the differentiation of dopamine neurons by...

journal_title：Journal of cell science

authors： Yang D,Li T,Wang Y,Tang Y,Cui H,Tang Y,Zhang X,Chen D,Shen N,Le W

更新日期：2012-04-01 00:00:00

abstract：:Murine mesenchymal stem cells are capable of differentiating in vitro into different lineages under stimulation with certain cytokines, growth factors and chemicals. However, the true capacity of these cells to contribute to different cell-types in vivo is still unclear, especially under minimal injury conditions. In ...

journal_title：Journal of cell science

authors： Anjos-Afonso F,Siapati EK,Bonnet D

更新日期：2004-11-01 00:00:00

abstract：:Cells constantly adapt to various environmental changes and stresses. The way in which nutrient and stress levels in a cell feed back to control metabolism and growth are, unsurprisingly, extremely complex, as responding with great sensitivity and speed to the 'feast or famine, slack or stress' status of its environme...

journal_title：Journal of cell science

authors： Dokudovskaya S,Rout MP

更新日期：2015-06-15 00:00:00

abstract：:Previous studies have shown that unactivated lymphocytes bind to CS1 peptide and that the adhesion of these cells to high endothelium is inhibited by CS1 peptide. These results suggest that lymphocyte binding occurs via recognition of the CS1-containing splice variant of fibronectin expressed on the high endothelial s...

journal_title：Journal of cell science

authors： May MJ,Entwistle G,Humphries MJ,Ager A

更新日期：1993-09-01 00:00:00

abstract：:The glucocorticoid receptor and the mineralocorticoid receptor are hormone-dependent transcription factors. They regulate the excitability of rat hippocampus CA1 neurons in a coordinated fashion. We studied the spatial distribution of these transcription factors in nuclei of CA1 neurons by dual labeling immunocytochem...

journal_title：Journal of cell science

authors： van Steensel B,van Binnendijk EP,Hornsby CD,van der Voort HT,Krozowski ZS,de Kloet ER,van Driel R

更新日期：1996-04-01 00:00:00

abstract：:Cilia and flagella are eukaryotic organelles involved in multiple cellular functions. The primary cilium is generally non motile and found in numerous vertebrate cell types where it controls key signalling pathways. Despite a common architecture, ultrastructural data suggest some differences in their organisation. Her...

journal_title：Journal of cell science

authors： Molla-Herman A,Ghossoub R,Blisnick T,Meunier A,Serres C,Silbermann F,Emmerson C,Romeo K,Bourdoncle P,Schmitt A,Saunier S,Spassky N,Bastin P,Benmerah A

更新日期：2010-05-15 00:00:00

abstract：:How vesicle trafficking components actively contribute to regulation of paracrine signaling is unclear. We genetically uncovered a requirement for α-soluble NSF attachment protein (α-Snap) in the activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway during Drosophila egg de...

journal_title：Journal of cell science

authors： Saadin A,Starz-Gaiano M

更新日期：2018-11-30 00:00:00

abstract：:Pieces of small intestine from newborn, I- and 6-day-old piglets were incubated in vitro and ligated segments were incubated in vivo with polycationic ferritin (PCF) to determine the distribution and possible role in protein uptake of anionic sites on membranes at the luminal surfaces of the epithelial cells. Most PCF...

journal_title：Journal of cell science

authors： Chase CC,Munn EA

更新日期：1980-12-01 00:00:00

abstract：:Phagosomes are formed when phagocytic cells ingest particles such as bacteria, viruses or synthetic beads of different kinds. The environment within the phagosome gradually changes to generate degradative conditions. These changes require multiple interactions between the maturing phagosomes and the endocytic and the ...

journal_title：Journal of cell science

authors： Tjelle TE,Saigal B,Froystad M,Berg T

更新日期：1998-01-01 00:00:00

abstract：:Stages of meiosis from the bluebell Endymion non-scriptus (L.) were studied by electron microscopy. The nucleolus went through the process of segregation at the beginning of meiosis with the movement to its surface of a pale-staining region. This region was shown to be the same as that called the 'L zone' or lacunae o...

journal_title：Journal of cell science

authors： Jordan EG,Luck BT

更新日期：1976-10-01 00:00:00

abstract：:The proteasome is the major degradation machinery of the cell that regulates multiple cellular processes as diverse as cell cycle, signal transduction and gene expression. Recognition and unfolding of target proteins involves the regulatory cap whose base contains six AAA-ATPases that display reverse chaperone activit...

journal_title：Journal of cell science

authors： Müller D,Nagel AC,Maier D,Preiss A

更新日期：2006-01-15 00:00:00

abstract：:During muscle development myosin molecules form symmetrical thick filaments, which integrate with the thin filaments to produce the regular sarcomeric lattice. In Drosophila indirect flight muscles (IFMs) the details of this process can be studied using genetic approaches. The weeP26 transgenic line has a GFP-encoding...

journal_title：Journal of cell science

authors： Orfanos Z,Sparrow JC

更新日期：2013-01-01 00:00:00

abstract：:Intermediate filament protein keratin 8 (K8) binds to heat shock protein 70 (Hsp70) and p38 MAPK, and is phosphorylated at Ser74 by p38α (MAPK14, hereafter p38). However, a p38 binding site on K8 and the molecular mechanism of K8-p38 interaction related to Hsp70 are unknown. Here, we identify a p38 docking site on K8 ...

journal_title：Journal of cell science

authors： Lee SY,Kim S,Lim Y,Yoon HN,Ku NO

更新日期：2019-09-26 00:00:00

abstract：:Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson’s disease, but the precise physiological function of the protein remains ill-defined. Recently, our group proposed a model in which LRRK2 kinase activity is part of an EndoA phosphorylation cycle that facilitates efficient vesicle formatio...

journal_title：Journal of cell science

authors： Arranz AM,Delbroek L,Van Kolen K,Guimarães MR,Mandemakers W,Daneels G,Matta S,Calafate S,Shaban H,Baatsen P,De Bock PJ,Gevaert K,Vanden Berghe P,Verstreken P,De Strooper B,Moechars D

更新日期：2015-02-01 00:00:00

abstract：:The Sar1 GTPase controls coat assembly on coat protein complex II (COPII)-coated vesicles, which mediate protein transport from the endoplasmic reticulum (ER) to the Golgi. The GTP-bound form of Sar1, activated by the ER-localized guanine nucleotide exchange factor (GEF) Sec12, associates with the ER membrane. GTP hyd...

journal_title：Journal of cell science

authors： Kurokawa K,Suda Y,Nakano A

更新日期：2016-09-01 00:00:00

abstract：:Microdomains have been proposed to explain specificity in the myriad of possible cellular targets of cAMP. Local differences in cAMP levels can be generated by phosphodiesterases, which control the diffusion of cAMP. Here, we address the possibility that adenylyl cyclases, the source of cAMP, can be primary architects...

journal_title：Journal of cell science

authors： Wachten S,Masada N,Ayling LJ,Ciruela A,Nikolaev VO,Lohse MJ,Cooper DM

更新日期：2010-01-01 00:00:00

abstract：:Onconase is an RNase with a very specific property because it is selectively toxic to transformed cells. This toxin is thought to recognize cell surface receptors, and the protection conferred by metabolic poisons against Onconase toxicity indicated that this RNase relies on endocytic uptake to kill cells. Nevertheles...

journal_title：Journal of cell science

authors： Rodríguez M,Torrent G,Bosch M,Rayne F,Dubremetz JF,Ribó M,Benito A,Vilanova M,Beaumelle B

更新日期：2007-04-15 00:00:00

abstract：:Intracellular membrane fusion occurs with exquisite coordination and specificity. Each fusion event requires three basic components: Rab-GTPases organize the fusion site; SNARE proteins act during fusion; and N-ethylmaleimide-sensitive factor (NSF) plus its cofactor alpha-SNAP are required for recycling or activation ...

journal_title：Journal of cell science

authors： Ungermann C,Langosch D

更新日期：2005-09-01 00:00:00

abstract：:Junction dynamics of endothelial cells are based on the integration of signal transduction, cytoskeletal remodeling and contraction, which are necessary for the formation and maintenance of monolayer integrity, but also enable repair and regeneration. The VE-cadherin-catenin complex forms the molecular basis of the ad...

journal_title：Journal of cell science

authors： Cao J,Schnittler H

更新日期：2019-01-03 00:00:00

abstract：:A key signaling event that is responsible for gradient sensing in eukaryotic cell chemotaxis is a phosphatidylinositol (PtdIns) lipid reaction system. The self-organization activity of this PtdIns lipid system induces an inherent polarity, even in the absence of an external chemoattractant gradient, by producing a loc...

journal_title：Journal of cell science

authors： Shibata T,Nishikawa M,Matsuoka S,Ueda M

更新日期：2012-11-01 00:00:00

abstract：:During development, general body plan information must be translated into distinct morphologies of individual cells. Shaping cells is thought to involve cortical cytoskeletal components and Bin-Amphiphysin-Rvs167 (BAR) superfamily proteins. We therefore conducted comprehensive side-by-side loss-of-function studies of ...

journal_title：Journal of cell science

authors： Schüler S,Hauptmann J,Perner B,Kessels MM,Englert C,Qualmann B

更新日期：2013-01-01 00:00:00

abstract：:The conjugation junction of Tetrahymena is the specialized site where plasma membrane fusion occurs between two cells of complementary mating types. The junction is constructed through a series of cooperative interactions and morphogenetic steps. A contact-mediated interaction between free-swimming, sexually mature an...

journal_title：Journal of cell science

authors： Wolfe J

更新日期：1985-02-01 00:00:00

abstract：:Neutrophil migration is vital for immunity and precedes effector functions such as pathogen killing. Here, we report that this process is regulated by the Rab27a GTPase, a protein known to control granule exocytosis. Rab27a-deficient (Rab27a KO) neutrophils exhibit migration defects in vitro and in vivo, and live-cell...

journal_title：Journal of cell science

authors： Singh RK,Liao W,Tracey-White D,Recchi C,Tolmachova T,Rankin SM,Hume AN,Seabra MC

更新日期：2012-04-01 00:00:00

abstract：:Intracellular signal transduction occurs through cascades of reactions involving dozens of proteins that transmit signals from the cell surface, through a crowded cellular environment filled with organelles and a filamentous cytoskeleton, to specific targets. Numerous signaling molecules are immobilized or transiently...

journal_title：Journal of cell science

authors： Forgacs G,Yook SH,Janmey PA,Jeong H,Burd CG

更新日期：2004-06-01 00:00:00

abstract：:Although the long-term effects of all-trans retinoic acid (RA) on neuronal growth and differentiation have been intensively studied, nothing is known about its effect on synaptic transmission. Here we show that RA rapidly and specifically enhances the spontaneous acetylcholine release at developing neuromuscular synap...

journal_title：Journal of cell science

authors： Liao YP,Ho SY,Liou JC

更新日期：2004-06-15 00:00:00

abstract：:We report a fast method for the isolation of homogeneous C-protein from bovine skeletal muscle. In electron micrographs C-protein appears as short rods with a relatively uniform length of about 50 nm. Protein sequencing shows a single N-terminal sequence. Radio-labelled C-protein strongly decorates titin II and myosin...

journal_title：Journal of cell science

authors： Fürst DO,Vinkemeier U,Weber K

更新日期：1992-08-01 00:00:00