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Total oxidant-scavenging capacities of plasma from glycogen storage disease type Ia patients as measured by cyclic voltammetry, FRAP and luminescence techniques.

Abstract：

:It has been suggested that the very low incidence of atherosclerosis in glycogen storage disease type Ia (GSD Ia) subjects might be attributed to elevated levels of uric acid, one of the potent low molecular- weight antioxidants found in plasma. The present communication describes a use of two analytical methods-cyclic voltammetry and ferric reducing ability of plasma-and also two chemiluminescence methods to evaluate the total oxidant-scavenging capacities (TOSC) of plasma from GSD Ia patients. Our results verified the elevation of TOSC in GSD Ia patients and we propose the inclusion of luminescence and cyclic voltammetry assays as reliable methods for estimating TOSC in a variety of clinical disorders. Our findings with the cyclic voltammetry method add support to the assumption that the elevated uric acid levels might be the main contributor to plasma antioxidant capacity and possible protection against atherosclerosis.

journal_name

J Inherit Metab Dis

journal_title

Journal of inherited metabolic disease

authors

Koren E,Lipkin J,Klar A,Hershkovitz E,Ginsburg I,Kohen R

doi

10.1007/s10545-009-1242-5

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

651

issue

5

eissn

0141-8955

issn

1573-2665

pii

10.1007/s10545-009-1242-5

journal_volume

32

pub_type

杂志文章

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