Abstract：
OBJECTIVE:To review the current management of pediatric genitourinary rhabdomyosarcoma (RMS). METHODS:Studies performed by the Intergroup Rhabdomyosarcoma Study Group, Children's Oncology Group (COG), International Society of Paediatric Oncology (SIOP) and others over the past 10 years were reviewed to compare the use of surgery, chemotherapy, and radiotherapy for treatment of RMS and their associated outcomes. RESULTS:Equivalent overall survival rates were reported in the last COG and SIOP trials, with worse event-free survival rates for bladder/prostate RMS in SIOP trials. The use of radiotherapy for local control was the main difference between current COG and SIOP protocols. Surgery is used to diagnose RMS, and for local control after chemotherapy. Chemotherapy is used for systemic control of RMS, but metastatic RMS will require new approaches. CONCLUSION:Risk stratification and risk-based therapy are being studied to decrease morbidity from treatment of RMS. The proper role of surgery vs radiotherapy for local control and whether additional treatment with second-line chemotherapy outweighs the avoidance of radiotherapy remain to be defined.
journal_name
J Pediatr Uroljournal_title
Journal of pediatric urologyauthors
Wu HY,Snyder HM 3rd,Womer RBdoi
10.1016/j.jpurol.2009.06.011subject
Has Abstractpub_date
2009-12-01 00:00:00pages
501-6issue
6eissn
1477-5131issn
1873-4898pii
S1477-5131(09)00389-1journal_volume
5pub_type
杂志文章,评审abstract：INTRODUCTION:Preoperative hormonal stimulation (PHS) is commonly administered to improve hypospadias outcomes. However, current literature provides no clear evidence to support its use, and controversies exist regarding its effect on postoperative complications. Herein we systematically evaluate the effect of PHS on po...
journal_title：Journal of pediatric urology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jpurol.2017.06.019
更新日期：2017-10-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy of fibrin sealant for repair of urethrocutaneous fistula after multiple failed hypospadias and epispadias surgeries. MATERIALS AND METHODS:The study population comprised 11 boys (mean age 12.18 years) with history of hypospadias or epispadias and at least two failed fistula repair oper...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2010.06.004
更新日期：2011-08-01 00:00:00
abstract：INTRODUCTION:Minimally invasive surgery has become an important aspect of Pediatric Urology fellowship training. In 2014, the Accreditation Council for Graduate Medical Education published the Pediatric Urology Milestone Project as a metric of fellow proficiency in multiple facets of training, including laparoscopic/ro...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2016.08.012
更新日期：2017-02-01 00:00:00
abstract：:The Mitrofanoff procedure, first described in 1980, has been widely adopted for pediatric continent urinary diversion to increase patient independence and continence, decrease morbidity and infections, and preserve renal function. Although this principle employs the appendix primarily, numerous other tissue conduits h...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2005.02.001
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND:Urinary continence is a common goal for children with spina bifida and their physicians. However, definitions of urinary continence vary widely across published studies. We systematically assessed the utilization of common definitions of urinary continence in the spina bifida literature. METHODS:We searched...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2013.02.006
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:Congenital megaprepuce is a specific form of buried penis. Children affected by this malformation usually suffer from a subjective difficulty in voiding which is the main indication for early surgical correction. The aim of this study was to report a single center's 12-year experience in the treatment of mega...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2012.10.010
更新日期：2013-12-01 00:00:00
abstract：PURPOSE:Congenital obstructive uropathy (COU) is a leading cause of pediatric chronic kidney disease (CKD). Urinary tract infections (UTIs) pose a risk for ascending infections and CKD in patients with COU. We evaluated the impact of comorbid UTIs on hospital charges and length of stay (LOS) for pediatric COU discharge...
journal_title：Journal of pediatric urology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jpurol.2011.10.021
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Congenital adrenal hyperplasia (CAH) consists of a group of diseases characterized by an enzyme deficiency, particularly 21-hydroxylase deficiency. The condition may present in the simple virilizing form or in the salt-wasting form, with varying degrees of genital ambiguity. The non-heterosexual orientation ...
journal_title：Journal of pediatric urology
pub_type： 杂志文章,评审
doi：10.1016/j.jpurol.2018.08.004
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVES:(1) Determine the number of urologic conditions diagnosed by computed tomography (CT) in children in the emergency department setting. (2) Identify which diagnoses were incidental. (3) Determine how often there was urologic follow-up by a local pediatric urologist. PATIENTS AND METHODS:We reviewed the chart...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2012.05.014
更新日期：2013-10-01 00:00:00
abstract：INTRODUCTION:As there is only scarce information on the parents' view of the cosmetic outcome after hypospadias surgery we aimed to evaluate whether the results of the hypospadias objective penile evaluation (HOPE) score are transferable to parents satisfaction as measured by the pediatric penile perception score (PPPS...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2015.10.010
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:To investigate the feasibility of correcting coexistent penile torsion and chordee without hypospadias by mobilization of the urethra and spongiosum. MATERIALS AND METHODS:A retrospective study of nine patients with simultaneous penile torsion and chordee without hypospadias was undertaken between January 20...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2014.06.016
更新日期：2014-12-01 00:00:00
abstract：INTRODUCTION:Robot-assisted laparoscopic pyeloplasty (RALP) has been gaining acceptance among pediatric urologists. Over 300 have been described in the literature, but few studies have evaluated the role of RALP in infants alone. OBJECTIVE:We sought to examine the operative experience and outcomes of RALP in a cohort ...
journal_title：Journal of pediatric urology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jpurol.2014.11.025
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:The ICCS defines OAB by the subjective symptom of urgency; detrusor overactivity (DO) is only implied. While no other symptom is required, OAB can also be associated with urinary frequency, decreased functional bladder capacity, and incontinence. OBJECTIVE:We sought to determine how often these associated f...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2017.02.010
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Posterior urethral valves (PUVs) are one of the leading causes of pediatric chronic kidney disease (CKD). Growth impairment is prevalent in pediatric CKD, and children with PUVs are at high risk for growth retardation. OBJECTIVE:The objective of this study was to describe growth profiles in PUVs and to iden...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2019.03.001
更新日期：2019-05-01 00:00:00
abstract：INTRODUCTION:Long-term continence outcomes for patients with bladder exstrophy are lacking in the literature. The complete primary repair of exstrophy (CPRE) is a widely adopted approach that seeks to normalize anatomy at the initial repair, thereby allowing early bladder filling and cycling. Previous reports of contin...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2016.04.005
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:To study the factors that may influence the effectiveness of 0.2% betamethasone/hyaluronidase cream in the treatment of phimosis. METHODS:We treated 427 patients (3-10 years old, mean 6.33) in a prospective, randomized, blind study, with 214 patients on a 4-week and 213 patients on an 8-week course. All pati...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2006.05.006
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:There is an ongoing quest on how to minimize complications in hypospadias surgery. There is however a lack of high-quality data on the following parameters that might influence the outcome of primary hypospadias repair: age at initial surgery, the type of suture material, the initial technique, and the type ...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2014.11.014
更新日期：2015-04-01 00:00:00
abstract：INTRODUCTION:Nephrolithiasis is a major source of morbidity in the United States. In recent decades, there has been a notable increase in stone incidence in the pediatric population. We investigate whether recurrent stone formers who had their initial stone episode earlier in life are at risk for more frequent stone re...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2020.03.014
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVE:Large bladder diverticulae, i.e. with a diameter measuring at least one-third of the bladder diameter on voiding cystourethrography, constitute an unusual but serious cause of obstructive uropathy in childhood. Their operative management entails meticulous reconstruction of the lower urinary tract. We report ...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2005.01.005
更新日期：2005-08-01 00:00:00
abstract：OBJECTIVE:In the US, there has been an evolution in the practice of pediatric urology from a primary academic sub-specialty focused on reconstruction of major congenital genitorurinary abnormalities to a mixed academic and private practice that serves as the primary care giver for all pediatric urologic concerns. The e...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2010.12.009
更新日期：2011-08-01 00:00:00
abstract：:The ability to consistently review abstracts in an unbiased and objective fashion is a skill that most academics hope to master. However, robust standardized rating systems are sparse, with most scientific boards leaving the task of rating abstracts poorly defined and at the whim of the reviewer. In an effort to bring...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2018.07.009
更新日期：2018-10-01 00:00:00
abstract：:Bladder trabeculation (BT) is commonly noted on cystogram images of patients with neurogenic bladder (NB). BT is associated with a hostile bladder often requiring prompt, more aggressive management. We aimed to define and validate a reliable grading system for BT severity. The proposed grading system will improve clin...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2020.03.007
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Repair of distal hypospadias is one of the most common pediatric urology procedures in the US. However, the risk of postsurgical complications has been reported primarily from single-institution and tertiary center studies, with short duration of patient follow-up. OBJECTIVE:The aim of the study was to exam...
journal_title：Journal of pediatric urology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jpurol.2019.06.012
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:The differential diagnosis of an acute scrotum is of great importance in clinical practice and may be difficult in some cases. The aim of this study was to differentiate inflammatory from non-inflammatory causes of acute scrotum using relatively simple laboratory tests which can be performed quickly and easil...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2012.03.009
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:Predicting the fate of a unilateral non-palpable testis based on its scrotal counterpart has been recommended by some, yet disputed by others, and the question remains open. OBJECTIVE:To investigate the accuracy of contralateral testis hypertrophy in predicting the absence of a unilateral non-palpable testi...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2016.12.013
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:To report a novel cause of nocturnal enuresis (NE) and highlight the literature giving insight into this novel mechanism. PATIENT:A 12-year-old morbidly obese female with 2-year history of nightly secondary monosymptomatic NE. RESULTS:On evaluation, a history of severe sleep disturbed breathing was elicited...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2009.08.009
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Preputioplasty as a part of hypospadias repair restores the normal appearance of phallus, which is especially important in distal and mid penile hypospadias. However possibility of its inherent complications such as iatrogenic phimosis or preputial breakdown are the cause of controversy and reluctance regard...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2020.04.014
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVE:To determine the changes in number and morphology of interstitial cells of Cajal (ICC)-like cells (ICC-LC) at the ureteropelvic junction (UPJ) of rats after experimental distal ureteral obstruction. MATERIALS AND METHODS:Of a total of 109 rats, 20 served as controls (C), 20 underwent sham-operations (SH) and...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2008.12.006
更新日期：2009-08-01 00:00:00
abstract：PURPOSE:To investigate systematically the length of the urethra in girls with lower urinary tract symptoms. MATERIALS AND METHODS:In a group of 121 consecutive girls presented at a tertiary referral clinic for urinary incontinence or recurrent urinary tract infections, urethral length was measured by perineal ultrasou...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2009.10.013
更新日期：2010-08-01 00:00:00
abstract：:End-stage renal disease is becoming a contemporary global concern with increasing prevalence. The available treatment strategies are limited to dialysis and renal transplantation. However, limited organ supply and autoimmune rejection are the shortcomings that limit widespread application of transplantation. Favorably...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2018.01.008
更新日期：2018-04-01 00:00:00
