SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.

abstract：:Cell proliferation is regulated by the induction of growth promoting genes and the suppression of growth inhibitory genes. Malignant growth can result from the altered balance of expression of these genes in favor of cell proliferation. Induction of the transcription factor, c-Myc, promotes cell proliferation and tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee TC,Li L,Philipson L,Ziff EB

更新日期：1997-11-25 00:00:00

abstract：:We recognize, understand, and interact with objects through both vision and touch. Conceivably, these two sensory systems encode object shape in similar ways, which could facilitate cross-modal communication. To test this idea, we studied single neurons in macaque monkey intermediate visual (area V4) and somatosensory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yau JM,Pasupathy A,Fitzgerald PJ,Hsiao SS,Connor CE

更新日期：2009-09-22 00:00:00

abstract：:The human chaperonin Hsp60 is thought to play a role in the progression of Alzheimer's disease by mitigating against intracellular β-amyloid stress. Here, we show that the bacterial homolog GroEL (51% sequence identity) reduces the neurotoxic effects of amyloid-β(1-42) (Aβ42) on human neural stem cell-derived neuronal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wälti MA,Steiner J,Meng F,Chung HS,Louis JM,Ghirlando R,Tugarinov V,Nath A,Clore GM

更新日期：2018-12-18 00:00:00

abstract：:HIV protease inhibitors are a key component of anti-retroviral therapy, but their susceptibility to cytochrome P(450) metabolism reduces their systemic availability and necessitates repetitive dosing. Importantly, failure to maintain adequate inhibitor levels is believed to provide an opportunity for resistance to eme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marinec PS,Chen L,Barr KJ,Mutz MW,Crabtree GR,Gestwicki JE

更新日期：2009-02-03 00:00:00

abstract：:The partial amino acid sequences of human T-cell growth factors (TCGFs) isolated from normal peripheral blood lymphocytes and from a leukemia T-cell line (Jurkat) show that the amino-terminal sequences of the two proteins (15 residues) are identical. Oligonucleotides based on the published Jurkat TCGF DNA sequence wer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clark SC,Arya SK,Wong-Staal F,Matsumoto-Kobayashi M,Kay RM,Kaufman RJ,Brown EL,Shoemaker C,Copeland T,Oroszlan S

更新日期：1984-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by a progressive dysfunction of central neurons. Recent experimental evidence indicates that in the cortex, in addition to the silencing of a fraction of neurons, other neurons are hyperactive in amyloid-β (Aβ) plaque-enriched regions. However, it has remained unknown what com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Busche MA,Chen X,Henning HA,Reichwald J,Staufenbiel M,Sakmann B,Konnerth A

更新日期：2012-05-29 00:00:00

abstract：:The improvement of motor behavior, based on experience, is a form of learning that is critically dependent on the cerebellum. A well studied example of cerebellar motor learning is short-term saccadic adaptation (STSA). In STSA, information on saccadic errors is used to improve future saccades. The information optimiz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Catz N,Dicke PW,Thier P

更新日期：2008-05-20 00:00:00

abstract：:The field of perceptual learning has identified changes in perceptual templates as a powerful mechanism mediating the learning of statistical regularities in our environment. By measuring threshold-vs.-contrast curves using an orientation identification task under varying levels of external noise, the perceptual templ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bejjanki VR,Zhang R,Li R,Pouget A,Green CS,Lu ZL,Bavelier D

更新日期：2014-11-25 00:00:00

abstract：:Graphene oxide (GO), the main precursor of graphene-based materials made by solution processing, is known to be very stiff. Indeed, it has a Young's modulus comparable to steel, on the order of 300 GPa. Despite its very high stiffness, we show here that GO is superflexible. We quantitatively measure the GO bending rig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poulin P,Jalili R,Neri W,Nallet F,Divoux T,Colin A,Aboutalebi SH,Wallace G,Zakri C

更新日期：2016-10-04 00:00:00

abstract：:Ribonucleotide reductase provides deoxynucleotides for nuclear and mitochondrial (mt) DNA replication and repair. The mammalian enzyme consists of a catalytic (R1) and a radical-generating (R2 or p53R2) subunit. During S-phase, a R1/R2 complex is the major provider of deoxynucleotides. p53R2 is induced by p53 after DN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pontarin G,Fijolek A,Pizzo P,Ferraro P,Rampazzo C,Pozzan T,Thelander L,Reichard PA,Bianchi V

更新日期：2008-11-18 00:00:00

abstract：:While the physical dimensions of climate change are now routinely assessed through multimodel intercomparisons, projected impacts on the global ocean ecosystem generally rely on individual models with a specific set of assumptions. To address these single-model limitations, we present standardized ensemble projections...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lotze HK,Tittensor DP,Bryndum-Buchholz A,Eddy TD,Cheung WWL,Galbraith ED,Barange M,Barrier N,Bianchi D,Blanchard JL,Bopp L,Büchner M,Bulman CM,Carozza DA,Christensen V,Coll M,Dunne JP,Fulton EA,Jennings S,Jones MC,

更新日期：2019-06-25 00:00:00

abstract：:The hypothalamic arcuate nucleus is involved in the control of energy intake and expenditure and may participate in the pathogenesis of eating disorders such as anorexia nervosa (AN) and bulimia nervosa (BN). Two systems are of particular interest in this respect, synthesizing alpha-melanocyte-stimulating hormone (alp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fetissov SO,Hallman J,Oreland L,Af Klinteberg B,Grenbäck E,Hulting AL,Hökfelt T

更新日期：2002-12-24 00:00:00

abstract：:In a well networked community, there is intense social interaction, and information disseminates briskly and broadly. This is important if the environment is volatile (i.e., keeps changing) and individuals never stop searching for fresh opportunities. Here, we present a simple model that attributes the rise of a dynam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marsili M,Vega-Redondo F,Slanina F

更新日期：2004-02-10 00:00:00

abstract：:Neuronal dynamics display a complex spatiotemporal structure involving the precise, context-dependent coordination of activation patterns across a large number of spatially distributed regions. Functional magnetic resonance imaging (fMRI) has played a central role in demonstrating the nontrivial spatial and topologica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zalesky A,Fornito A,Cocchi L,Gollo LL,Breakspear M

更新日期：2014-07-15 00:00:00

abstract：:In eukaryotes, microtubules are essential for cellular plasticity and dynamics. Here we show that P300/CBP-associated factor (PCAF), a kinetochore-associated acetyltransferase, acts as a negative modulator of microtubule stability through acetylation of EB1, a protein that controls the plus ends of microtubules. PCAF ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xia P,Wang Z,Liu X,Wu B,Wang J,Ward T,Zhang L,Ding X,Gibbons G,Shi Y,Yao X

更新日期：2012-10-09 00:00:00

abstract：:Life-long protection from disease through immunization can be accomplished through individual or community protection. Individual protection is the goal for vaccination against diseases that have inanimate or animal reservoirs or that pose risks for certain populations. Community protection is the goal for vaccination...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dowdle WR,Orenstein WA

更新日期：1994-03-29 00:00:00

abstract：:A system is described for assembling infectious bacteriophage phi 6 nucleocapsids in vitro. Procapsids encoded by cDNA copies of genomic segment L in Escherichia coli were used to package and replicate viral RNA segments. The resulting filled particles were shown to be capable of infecting host cell spheroplasts after...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olkkonen VM,Gottlieb P,Strassman J,Qiao XY,Bamford DH,Mindich L

更新日期：1990-12-01 00:00:00

abstract：:Muscular dystrophy is a general term encompassing muscle disorders that cause weakness and wasting, typically leading to premature death. Membrane instability, as a result of a genetic disruption within the dystrophin-glycoprotein complex (DGC), is thought to induce myofiber degeneration, although the downstream mecha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Millay DP,Goonasekera SA,Sargent MA,Maillet M,Aronow BJ,Molkentin JD

更新日期：2009-11-10 00:00:00

abstract：:Mutations in the human DYNC1H1 gene are associated with neurological diseases. DYNC1H1 encodes the heavy chain of cytoplasmic dynein-1, a 1.4-MDa motor complex that traffics organelles, vesicles, and macromolecules toward microtubule minus ends. The effects of the DYNC1H1 mutations on dynein motility, and consequently...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoang HT,Schlager MA,Carter AP,Bullock SL

更新日期：2017-02-28 00:00:00

abstract：:Stable structures of icosahedral symmetry can serve numerous functional roles, including chemical microencapsulation and delivery of drugs and biomolecules, epitope presentation to allow for an efficient immunization process, synthesis of nanoparticles of uniform size, observation of encapsulated reactive intermediate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olson AJ,Hu YH,Keinan E

更新日期：2007-12-26 00:00:00

abstract：:Here, the ATP-binding, ATP hydrolysis, mispair-binding, sliding clamp formation, and Mlh1-Pms1 complex interaction properties of dominant mutant Msh2-Msh6 complexes have been characterized. The results demonstrate two mechanisms for dominance. In one, seen with the Msh6-S1036P and Msh6-G1067D mutant complexes, the mut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hess MT,Mendillo ML,Mazur DJ,Kolodner RD

更新日期：2006-01-17 00:00:00

abstract：:Many Drosophila non-long terminal repeat (LTR) retrotransposons actively transpose into internal, gene-rich regions of chromosomes but do not transpose onto chromosome ends. HeT-A and TART are remarkable exceptions; they form telomeres of Drosophila by repeated transpositions onto the ends of chromosomes and never tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rashkova S,Karam SE,Pardue ML

更新日期：2002-03-19 00:00:00

abstract：:The satellite RNA of tobacco ringspot virus depends upon tobacco ringspot virus for its replication and source of coat protein. The satellite RNA reduces virus accumulation and the severity of virus-induced symptoms. Repetitive sequence, dimeric, and higher forms of the satellite RNA are known to autolytically process...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buzayan JM,Gerlach WL,Bruening G

更新日期：1986-12-01 00:00:00

abstract：:When fibers of fibrin clots or fragments of fibrinogen pellets are negatively stained they exhibit in the electron microscope characteristic patterns of cross-striations or bands. Those found in pellet material are indistinguishable from those seen in thrombin-induced fibrin fibers. The pattern seen in fibrin from bov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams RC

更新日期：1983-03-01 00:00:00

abstract：:The history of the genus Pan is a topic of enduring interest. Chimpanzees (Pan troglodytes) are often divided into subspecies, but the population structure and genetic history of chimpanzees across Africa remain unclear. Some population genetics studies have led to speculation that, until recently, this species consti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gonder MK,Locatelli S,Ghobrial L,Mitchell MW,Kujawski JT,Lankester FJ,Stewart CB,Tishkoff SA

更新日期：2011-03-22 00:00:00

abstract：:Neural activity and neurotrophins induce synaptic remodeling in part by altering gene expression. A cDNA encoding a glycosylphoshatidylinositol-anchored protein was identified by screening for hippocampal genes that are induced by neural activity. This molecule, named neuritin, is expressed in postmitotic-differentiat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naeve GS,Ramakrishnan M,Kramer R,Hevroni D,Citri Y,Theill LE

更新日期：1997-03-18 00:00:00

abstract：:In skeletal muscle, dihydropyridine receptors are functionally coupled to ryanodine receptors of the sarcoplasmic reticulum in triadic or diadic junctional complexes. In cardiac muscle direct physical or functional couplings have not been demonstrated. We have tested the hypothesis of functional coupling of L-type Ca2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sham JS,Cleemann L,Morad M

更新日期：1995-01-03 00:00:00

abstract：:The motility of cilia and flagella is powered by dynein ATPases associated with outer doublet microtubules. However, a flagellar kinesin-like protein that may function as a motor associates with the central pair complex. We determined that Chlamydomonas reinhardtii central pair kinesin Klp1 is a phosphoprotein and, li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yokoyama R,O'toole E,Ghosh S,Mitchell DR

更新日期：2004-12-14 00:00:00

abstract：:In a genetic screen of available T-DNA-mutagenized Arabidopsis populations for loci potentially involved in phytochrome (phy) signaling, we identified a mutant that displayed reduced seedling deetiolation under continuous red light, but little if any change in responsiveness to continuous far-red light. This behavior ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huq E,Tepperman JM,Quail PH

更新日期：2000-08-15 00:00:00

abstract：:Molecular dynamics simulations show that the desolvation rates of isotopes of Li(+), K(+), Rb(+), Ca(2+), Sr(2+), and Ba(2+) may have a relatively strong dependence on the metal cation mass. This inference is based on the observation that the exchange rate constant, k(wex), for water molecules in the first hydration s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hofmann AE,Bourg IC,DePaolo DJ

更新日期：2012-11-13 00:00:00