From the Cover: Directed, efficient, and versatile modifications of the Drosophila genome by genomic engineering.

abstract：:Nonspecific histone deacetylase (HDAC) inhibition has been shown to facilitate the extinction of drug-seeking behavior in a manner resistant to reinstatement. A key open question is which specific HDAC is involved in the extinction of drug-seeking behavior. Using the selective HDAC3 inhibitor RGFP966, we investigated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malvaez M,McQuown SC,Rogge GA,Astarabadi M,Jacques V,Carreiro S,Rusche JR,Wood MA

更新日期：2013-02-12 00:00:00

abstract：:The nuclear envelope is a unique topological structure formed by lipid membranes in eukaryotic cells. Unlike other membrane structures, the nuclear envelope comprises two concentric membrane shells fused at numerous sites with toroid-shaped pores that impart a "geometric" genus on the order of thousands. Despite the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torbati M,Lele TP,Agrawal A

更新日期：2016-10-04 00:00:00

abstract：:Spontaneous liposome formation is predicted in binary mixtures of fluid phase phospholipids and poly(n)ethylene oxide (PEO)-bearing lipids by using single chain mean field theory. The range of stability of the spontaneous liposomes is determined as a function of percentage of PEO-conjugated lipids and polymer molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szleifer I,Gerasimov OV,Thompson DH

更新日期：1998-02-03 00:00:00

abstract：:We studied the effect of N-cadherin, and its free or membrane-anchored cytoplasmic domain, on the level and localization of beta-catenin and on its ability to induce lymphocyte enhancer-binding factor 1 (LEF-1)-responsive transactivation. These cadherin derivatives formed complexes with beta-catenin and protected it f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sadot E,Simcha I,Shtutman M,Ben-Ze'ev A,Geiger B

更新日期：1998-12-22 00:00:00

abstract：:A hallmark of most neurodegenerative diseases, including those caused by polyglutamine expansion, is the formation of ubiquitin (Ub)-positive protein aggregates in affected neurons. This finding suggests that the Ub system may be involved in common mechanisms underlying these otherwise unrelated diseases. Here we repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donaldson KM,Li W,Ching KA,Batalov S,Tsai CC,Joazeiro CA

更新日期：2003-07-22 00:00:00

abstract：:Hypothesis directed proteomics offers higher throughput over global analyses. We show that immunoprecipitation (IP)-tandem mass spectrometry (LC-MS/MS) in H929 multiple myeloma (MM) cancer cells led to the discovery of a rare and unexpected BCR-ABL fusion, informing a therapeutic intervention using imatinib (Gleevec)....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breitkopf SB,Yuan M,Pihan GA,Asara JM

更新日期：2012-10-02 00:00:00

abstract：:A unique neuronal system was detected in the rat central nervous system by immunohistochemistry and radioimmunoassay with antibodies to salmon melanin-concentrating hormone (MCH). MCH-like immunoreactive (MCH-LI) cell bodies were confined to the hypothalamus. MCH-LI fibers were found throughout the brain but were most...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamir N,Skofitsch G,Bannon MJ,Jacobowitz DM

更新日期：1986-03-01 00:00:00

abstract：:The recent observation of superconductivity in [Formula: see text] has raised fundamental questions about the hierarchy of the underlying electronic structure. Calculations suggest that this system falls in the Mott-Hubbard regime, rather than the charge-transfer configuration of other nickel oxides and the supercondu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodge BH,Li D,Lee K,Osada M,Wang BY,Sawatzky GA,Hwang HY,Kourkoutis LF

更新日期：2021-01-12 00:00:00

abstract：:A major goal of tumor immunotherapy is the effective eradication of established metastases associated with the induction of a T cell-mediated protective immunity. We achieved this in a poorly immunogenic murine neuroblastoma model by gene therapy with a single chain interleukin 12 (scIL-12) fusion protein that assures...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lode HN,Dreier T,Xiang R,Varki NM,Kang AS,Reisfeld RA

更新日期：1998-03-03 00:00:00

abstract：:In normal messenger RNA for the human beta-globin chain, nucleotide sequences have been identified which can be matched to the amino-acid sequence of the abnormally long segment of the beta-chain of hemoglobin Cranston. The finding of these sequences strengthens the hypothesis that the betaCranston chain arose by a fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Forget BG,Marotta CA,Weissman SM,Cohen-Solal M

更新日期：1975-09-01 00:00:00

abstract：:Iodine is an important nutrient and a significant sink of tropospheric ozone, a climate-forcing gas and air pollutant. Ozone interacts with seawater iodide, leading to volatile inorganic iodine release that likely represents the largest source of atmospheric iodine. Increasing ozone concentrations since the preindustr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Legrand M,McConnell JR,Preunkert S,Arienzo M,Chellman N,Gleason K,Sherwen T,Evans MJ,Carpenter LJ

更新日期：2018-11-27 00:00:00

abstract：:We partially purified a preparation from Escherichia coli that proteolytically degrades the enzyme glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2]. The degradation is at least a two-step process. First, the glutamine synthetase undergoes an oxidative modification. This modification leads to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine RL,Oliver CN,Fulks RM,Stadtman ER

更新日期：1981-04-01 00:00:00

abstract：:The development of osteoclastic cell lines would greatly facilitate analysis of the cellular and molecular biology of bone resorption. Several cell lines have previously been reported to be capable of osteoclastic differentiation. However, such cell lines form at best only occasional excavations, suggesting that osteo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chambers TJ,Owens JM,Hattersley G,Jat PS,Noble MD

更新日期：1993-06-15 00:00:00

abstract：:Nascent precursors of phosphatidylinositol-glycan (PI-G)-linked membrane proteins contain a hydrophobic COOH-terminal sequence of 15-30 residues that is eliminated during processing to yield a newly exposed COOH terminus to which the PI-G moiety is added. There is no consensus as to the primary structure of the termin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Micanovic R,Kodukula K,Gerber LD,Udenfriend S

更新日期：1990-10-01 00:00:00

abstract：:In multicellular organisms, the higher order organization of chromatin during interphase and the reassembly of the nuclear envelope during mitosis are thought to involve an interaction between the nuclear lamina and chromatin. The nuclear distribution of lamins and of peripheral chromatin is highly correlated in vivo,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldberg M,Harel A,Brandeis M,Rechsteiner T,Richmond TJ,Weiss AM,Gruenbaum Y

更新日期：1999-03-16 00:00:00

abstract：:The polymerization of mixtures of Hb S with hemoglobins A, A2, and F has been investigated by analysis of the proportions of S and non-S hemoglobin both in the supernate and in the pellet after centrifugation. In all cases the non-S hemoglobin was incorporated into the polymer even in the absence of hybrids in the ord...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benesch RE,Edalji R,Benesch R,Kwong S

更新日期：1980-09-01 00:00:00

abstract：:In insulin resistant states such as type 2 diabetes, there is a high demand on the β-cell to synthesize and secrete insulin, which challenges the ability of the endoplasmic reticulum (ER) to synthesize and fold nascent proteins. This creates a state of ER stress that triggers a coordinated program referred to as the u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winnay JN,Dirice E,Liew CW,Kulkarni RN,Kahn CR

更新日期：2014-01-21 00:00:00

abstract：:WIN antiviral compounds bind human rhinovirus, as well as enterovirus and parechovirus, in an internal cavity located within the viral protein capsid. Access to the buried pocket necessitates deviation from the average viral protein structure identified by crystallography. We investigated the dissociation of WIN 52084...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Zhou Z,Post CB

更新日期：2005-05-24 00:00:00

abstract：:The cytochrome P-450 superfamily of enzymes catalyzes the oxidative metabolism of innumerable lipophilic compounds (e.g., drugs, carcinogens, steroids). Although the three-dimensional structure of a soluble bacterial P-450 (P-450cam) has been solved, little is known about the structures of the membrane-bound mammalian...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kronbach T,Larabee TM,Johnson EF

更新日期：1989-11-01 00:00:00

abstract：:Members of the arenavirus family, famous for their hemorrhagic syndromes, cause distinct neurological disorders; however, cellular and molecular targets as well as pathogenesis of peripheral nervous system disorders associated with these viruses are unknown. Using noncytolytic lymphocytic choriomeningitis virus, the p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rambukkana A,Kunz S,Min J,Campbell KP,Oldstone MB

更新日期：2003-12-23 00:00:00

abstract：:We have previously shown that the G protein of vesicular stomatitis virus (VSV-G) can be incorporated into the virions of retroviruses. Since expression of VSV-G is toxic to most mammalian cells, development of stable VSV-G packaging cell lines requires inducible VSV-G expression. We have modified the tetracycline-ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen ST,Iida A,Guo L,Friedmann T,Yee JK

更新日期：1996-09-17 00:00:00

abstract：:RNA-dependent RNA polymerases (RdRps) of the Nidovirales (Coronaviridae, Arteriviridae, and 12 other families) are linked to an amino-terminal (N-terminal) domain, called NiRAN, in a nonstructural protein (nsp) that is released from polyprotein 1ab by the viral main protease (Mpro). Previously, self-GMPylation/UMPylat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slanina H,Madhugiri R,Bylapudi G,Schultheiß K,Karl N,Gulyaeva A,Gorbalenya AE,Linne U,Ziebuhr J

更新日期：2021-02-09 00:00:00

abstract：:The O(2) reduction site of cytochrome c oxidase (CcO), comprising iron (Fe(a3)) and copper (Cu(B)) ions, is probed by x-ray structural analyses of CO, NO, and CN(-) derivatives to investigate the mechanism of the complete reduction of O(2). Formation of the derivative contributes to the trigonal planar coordination of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muramoto K,Ohta K,Shinzawa-Itoh K,Kanda K,Taniguchi M,Nabekura H,Yamashita E,Tsukihara T,Yoshikawa S

更新日期：2010-04-27 00:00:00

abstract：:Gonadal steroids have traditionally been found to have short-term effects on the mating behavior of adult vertebrates, such that increased steroid hormone levels influence behavior over the course of a few days. Long-term effects also have been observed in which embryonic exposure to steroid hormone influences the sex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crews D

更新日期：1991-05-01 00:00:00

abstract：:Repeated within-day testing on a texture discrimination task leads to retinotopically specific decreases in performance. Although perceptual learning has been shown to be highly specific to the retinotopic location and characteristics of the trained stimulus, the specificity of perceptual deterioration has not been st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mednick SC,Arman AC,Boynton GM

更新日期：2005-03-08 00:00:00

abstract：:Metal detoxification is essential for bacteria's survival in adverse environments and their pathogenesis in hosts. Understanding the underlying mechanisms is crucial for devising antibacterial treatments. In the Gram-negative bacterium Escherichia coli, membrane-bound sensor CusS and its response regulator CusR togeth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu B,Sengupta K,Genova LA,Santiago AG,Jung W,Krzemiński Ł,Chakraborty UK,Zhang W,Chen P

更新日期：2020-06-16 00:00:00

abstract：:The Etruscans, the only preclassical European population that has been genetically characterized so far, share only two haplotypes with their modern geographic counterparts, the Tuscans, who, nonetheless, appear to be their closest relatives. We modeled 10 demographic scenarios spanning the last 2,500 years and tested...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belle EM,Ramakrishnan U,Mountain JL,Barbujani G

更新日期：2006-05-23 00:00:00

abstract：:The B cell developmental pathway represents a leading system for the analysis of regulatory circuits that orchestrate cell fate specification and commitment. Considerable progress has been achieved within the past decade in the identification and genetic analysis of various regulatory components. These components incl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singh H,Medina KL,Pongubala JM

更新日期：2005-04-05 00:00:00

abstract：:Thermotaxis by individual amoebae of Dictyostelium discoideum on a temperature gradient is described. These amoebae show positive thermotaxis at temperatures between 14 degrees C and 28 degrees C shortly (3 hr) after food depletion. Increasing time on the gradient reduces the positive thermotactic response at the lowe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong CB,Fontana DR,Poff KL

更新日期：1983-09-01 00:00:00

abstract：:Learning the properties of an image associated with human gaze placement is important both for understanding how biological systems explore the environment and for computer vision applications. There is a large literature on quantitative eye movement models that seeks to predict fixations from images (sometimes termed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kümmerer M,Wallis TS,Bethge M

更新日期：2015-12-29 00:00:00