Does obstetric brachial plexus injury influence speech dominance?

Abstract:

OBJECTIVE:Right-handedness and left-sided language lateralization is an unresolved mystery with unknown cause/effect relations. Most studies suggest that the language lateralization is related to a fundamental brain asymmetry: right-handedness may be secondary. We analyzed the possibility of an opposite cause/effect relation: whether asymmetric hand usage (as a cause) can influence language lateralization (as a consequence). METHODS:We determined language lateralization by functional magnetic resonance imaging in 15 subjects whose upper limb (UL) had been injured at birth because of unilateral damage of the brachial plexus. These subjects were able to use only one (the noninjured) UL perfectly. RESULTS:We found correlation between the severity of right-sided UL injuries and hand usage dysfunction and the degree of left-to-right shift of language lateralization. There was, however, not a complete switch of language lateralization. INTERPRETATION:Right-sided UL injury can induce a left-to-right shift in language lateralization, suggesting that hand usage can influence language lateralization. These findings may contradict the broadly accepted theory that right-handedness is a secondary phenomenon caused by left-sided hemispheric language lateralization. However, the cause/effect problem between asymmetric hand usage and language lateralization is not resolved in this study. Our findings may support the theory that gestures had a crucial role in human language evolution and is a part of the language system even today.

journal_name

Ann Neurol

journal_title

Annals of neurology

authors

Auer T,Pinter S,Kovacs N,Kalmar Z,Nagy F,Horvath RA,Koszo B,Kotek G,Perlaki G,Koves M,Kalman B,Komoly S,Schwarcz A,Woermann FG,Janszky J

doi

10.1002/ana.21538

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

57-66

issue

1

eissn

0364-5134

issn

1531-8249

journal_volume

65

pub_type

杂志文章
  • Periodic paralysis and the sodium-potassium pump.

    abstract::Analysis of the pathophysiology of hypokalemic paralysis, as it occurs in barium poisoning, chronic potassium deficiency, and thyrotoxicosis, suggests that these disorders may have a similar mechanism. An increased ratio of muscle sodium permeability to potassium permeability reduces the ionic diffusion potential, whi...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410110602

    authors: Layzer RB

    更新日期:1982-06-01 00:00:00

  • Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson's disease.

    abstract::Microelectrode recording methods for stereotactic localization of the subthalamic nucleus (STN) and surrounding structures are described. These methods accurately define targets for chronic deep brain stimulation in the treatment of Parkinson's disease. Mean firing rates and a burst index were determined for all recor...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410440407

    authors: Hutchison WD,Allan RJ,Opitz H,Levy R,Dostrovsky JO,Lang AE,Lozano AM

    更新日期:1998-10-01 00:00:00

  • Clinical and magnetic resonance imaging findings in Batten disease: analysis of the major mutation (1.02-kb deletion).

    abstract::A total of 36 patients with Batten disease (juvenile-onset neuronal ceroid lipofuscinosis), homozygous or heterozygous for the major mutation, a 1.02-kb deletion, in the CLN3 gene, were studied to relate their genotype to their clinical phenotype. The onset of visual failure and epilepsy was highly concordant in both ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410420517

    authors: Järvelä I,Autti T,Lamminranta S,Aberg L,Raininko R,Santavuori P

    更新日期:1997-11-01 00:00:00

  • Steroid-responsive, progressive, focal measles virus brain infection.

    abstract::Chronic measles virus infection of the brain causes subacute sclerosing panencephalitis (SSPE), a progressive, relentless fatal disorder. We report a 52-year-old male who developed focal, chronic persistent measles virus infection of the brain following interferon and ribavirin therapy for hepatitis C, and who respond...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.24183

    authors: Steiner I,Livneh V,Hoffmann C,Nass D,Mor O,Chapman J

    更新日期:2014-06-01 00:00:00

  • Serological alpha 1-antichymotrypsin in Down's syndrome and Alzheimer's disease.

    abstract::alpha 1-Antichymotrypsin (ACT) is a serine protease inhibitor that is markedly elevated in the serum and cerebrospinal fluid of patients with Alzheimer's disease (AD). Patients with Down's syndrome are known to develop neuropathological changes of AD by age 40 years and many become demented. Therefore, in the present ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410320211

    authors: Brugge K,Katzman R,Hill LR,Hansen LA,Saitoh T

    更新日期:1992-08-01 00:00:00

  • Orbitofrontal and anterior cingulate cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease.

    abstract::Few studies evaluate neuropathological correlates of behavioral changes in Alzheimer disease (AD). We identified 31 autopsy patients with a diagnosis of definite AD. Behavioral changes were assessed with the Neuropsychiatric Inventory. Brain sections were collected from bilateral orbitofrontal and left anterior cingul...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:

    authors: Tekin S,Mega MS,Masterman DM,Chow T,Garakian J,Vinters HV,Cummings JL

    更新日期:2001-03-01 00:00:00

  • Unique aspects of human newborn cerebral metabolism evaluated with phosphorus nuclear magnetic resonance spectroscopy.

    abstract::In vivo phosphorus nuclear magnetic resonance spectroscopy (31P NMR) was used to evaluate the pattern of phosphate compounds in seven newborn babies (mean gestational age, 32 weeks; birth weight, 1,430 gm; age, 37 days) with a history of perinatal asphyxia. Spectra were collected in a 1.9 Tesla superconductive magnet ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410160509

    authors: Younkin DP,Delivoria-Papadopoulos M,Leonard JC,Subramanian VH,Eleff S,Leigh JS Jr,Chance B

    更新日期:1984-11-01 00:00:00

  • Novel amyloid precursor protein gene mutation (codon 665Asp) in a patient with late-onset Alzheimer's disease.

    abstract::Amyloid plaques in Alzheimer's disease contain beta-amyloid, encoded by portions of exons 16 and 17 of the amyloid precursor protein. The specific association of rare amyloid precursor protein mutations with some kindreds with early-onset familial Alzheimer's disease suggests that specific abnormalities in amyloid pre...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410350410

    authors: Peacock ML,Murman DL,Sima AA,Warren JT Jr,Roses AD,Fink JK

    更新日期:1994-04-01 00:00:00

  • Neurofibrillary degeneration of cholinergic and noncholinergic neurons of the basal forebrain in Alzheimer's disease.

    abstract::Two principal features of Alzheimer's disease (AD) are (1) the occurrence of neurofibrillary tangles (NFTs) and senile plaques, and (2) the loss of cortical cholinergic activity because of dysfunction of neurons in the basal forebrain cholinergic system. The relationship of these two abnormalities is an unresolved iss...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410200407

    authors: Rasool CG,Svendsen CN,Selkoe DJ

    更新日期:1986-10-01 00:00:00

  • Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications.

    abstract::Genomic triplication of the alpha-synuclein gene recently has been associated with familial Parkinson's disease in the Spellman-Muenter kindred. Here, we present an independent family, of Swedish-American descent, with hereditary early-onset parkinsonism with dementia due to alpha-synuclein triplication. Brain tissue ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.10846

    authors: Farrer M,Kachergus J,Forno L,Lincoln S,Wang DS,Hulihan M,Maraganore D,Gwinn-Hardy K,Wszolek Z,Dickson D,Langston JW

    更新日期:2004-02-01 00:00:00

  • Chronic opioid therapy as alternative treatment for post-herpetic neuralgia.

    abstract::Neurosurgical procedures such as the dorsal root entry zone operation, ganglionectomy, and spinal-cord stimulation have been offered to patients with intractable post-herpetic neuralgia (PHN). Poor efficacy or high morbidity have limited the overall usefulness of these procedures. We recently conducted a preliminary o...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410350716

    authors: Pappagallo M,Campbell JN

    更新日期:1994-01-01 00:00:00

  • A case-control study of apolipoprotein E genotypes in Alzheimer's disease associated with Down's syndrome. Dutch Study Group on Down's Syndrome and Ageing.

    abstract::The prevalence of clinical signs and neuropathological findings of Alzheimer's disease (AD) is high in Down's syndrome (DS). In the general population, the apolipoprotein E (ApoE) epsilon 4 isoform is an important risk for AD. We studied the allelic frequencies of ApoE in 26 DS cases fulfilling clinical diagnostic cri...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410380215

    authors: van Gool WA,Evenhuis HM,van Duijn CM

    更新日期:1995-08-01 00:00:00

  • Simvastatin enhances learning and memory independent of amyloid load in mice.

    abstract:OBJECTIVE:Normal aging is often associated with a decline in learning and memory functions. This decline is manifested to a much greater extent in Alzheimer's disease. Recent studies have indicated statins, a class of cholesterol-lowering drugs, as a potential therapy for Alzheimer's disease. Our objective was to deter...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.21053

    authors: Li L,Cao D,Kim H,Lester R,Fukuchi K

    更新日期:2006-12-01 00:00:00

  • Does tremor pace repetitive voluntary motor behavior in Parkinson's disease?

    abstract::In patients with Parkinson's disease and in normal subjects, the influence of tremor on repetitive voluntary movement was investigated in the index finger by comparing frequency of isometric force tremor with frequency of voluntary alternating isometric contractions. Tremor frequency, measured over the range from 0 to...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410300208

    authors: Logigian E,Hefter H,Reiners K,Freund HJ

    更新日期:1991-08-01 00:00:00

  • Neonatal vitamin D status and risk of multiple sclerosis.

    abstract:OBJECTIVE:Low vitamin D status at birth may be associated with risk of adult onset multiple sclerosis, but this link has not been studied directly. We assessed the relation between neonatal vitamin D concentrations, measured in stored blood samples, and risk of multiple sclerosis. METHODS:This was a population-based c...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.24210

    authors: Ueda P,Rafatnia F,Bäärnhielm M,Fröbom R,Korzunowicz G,Lönnerbro R,Hedström AK,Eyles D,Olsson T,Alfredsson L

    更新日期:2014-09-01 00:00:00

  • The time course and magnitude of spontaneous recovery of parkinsonism produced by intracarotid administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to monkeys.

    abstract::We studied rhesus monkeys with hemiparkinsonism or bilateral parkinsonism produced by unilateral or bilateral intracarotid administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Using a standardized clinical rating scale, 4 hemiparkinsonian monkeys showed a 13 to 56% (mean, 36%) spontaneous improvement during...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410290618

    authors: Kurlan R,Kim MH,Gash DM

    更新日期:1991-06-01 00:00:00

  • A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and Alzheimer disease.

    abstract::The causes of amyotrophic lateral sclerosis, Parkinson disease, and Alzheimer disease are unknown. Furthermore, treatment for two of these conditions is almost totally lacking. The thesis is presented that each of these disorders is due to lack of a disorder-specific neurotrophic hormone. The hormone would be elaborat...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410100602

    authors: Appel SH

    更新日期:1981-12-01 00:00:00

  • The syndrome of posterior choroidal artery territory infarction.

    abstract::Posterior choroidal artery (PChA) territory infarcts remain the least well-known type of thalamic infarcts. Our study of 10 personal cases, selected from 2,925 stroke patients admitted consecutively to a community-based primary care center, and 10 published cases of unilateral PChA territory infarct suggests that they...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410390614

    authors: Neau JP,Bogousslavsky J

    更新日期:1996-06-01 00:00:00

  • Cognitive impairment in lacunar strokes: the SPS3 trial.

    abstract:OBJECTIVE:Lacunar strokes are a leading cause of cognitive impairment and vascular dementia. However, adequate characterization of cognitive impairment is lacking. The aim of this study was to estimate the prevalence and characterize the neuropsychological impairment in lacunar stroke patients. METHODS:All English-spe...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.23733

    authors: Jacova C,Pearce LA,Costello R,McClure LA,Holliday SL,Hart RG,Benavente OR

    更新日期:2012-09-01 00:00:00

  • The frequency of multiple sclerosis in Italy: a descriptive study in Ferrara.

    abstract::Results of intensive prevalence surveys on multiple sclerosis carried out in different small regions of Italy have suggested that this country falls into the high-frequency zone for the disease. To verify this hypothesis by studying a large population, we conducted intensive incidence and prevalence survey in the prov...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410170117

    authors: Granieri E,Tola R,Paolino E,Rosati G,Carreras M,Monetti VC

    更新日期:1985-01-01 00:00:00

  • Cortical myoclonus in Angelman syndrome.

    abstract::Angelman syndrome (AS) results from lack of genetic contribution from maternal chromosome 15q11-13. This region encompasses three GABAA receptor subunit genes (beta3, alpha5, and gamma3). The characteristic phenotype of AS is severe mental retardation, ataxic gait, tremulousness, and jerky movements. We studied the mo...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410400109

    authors: Guerrini R,De Lorey TM,Bonanni P,Moncla A,Dravet C,Suisse G,Livet MO,Bureau M,Malzac P,Genton P,Thomas P,Sartucci F,Simi P,Serratosa JM

    更新日期:1996-07-01 00:00:00

  • Mutations in MICAL-1cause autosomal-dominant lateral temporal epilepsy.

    abstract:OBJECTIVE:Autosomal-dominant lateral temporal epilepsy (ADLTE) is a genetic focal epilepsy characterized by auditory symptoms. Two genes, LGI1 and RELN, encoding secreted proteins, are implicated in the etiology of ADLTE, but half of the affected families remain genetically unsolved, and the underlying molecular mechan...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25167

    authors: Dazzo E,Rehberg K,Michelucci R,Passarelli D,Boniver C,Vianello Dri V,Striano P,Striano S,Pasterkamp RJ,Nobile C

    更新日期:2018-03-01 00:00:00

  • Short- and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease.

    abstract::Six patients with Parkinson's disease were followed for 10 to 72 months after human embryonic mesencephalic tissue from four to seven donors was grafted unilaterally into the putamen (4 patients) or putamen plus caudate (2 patients). After 8 to 12 months, positron emission tomography showed a 68% increase of 6-L-[18F]...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410420115

    authors: Wenning GK,Odin P,Morrish P,Rehncrona S,Widner H,Brundin P,Rothwell JC,Brown R,Gustavii B,Hagell P,Jahanshahi M,Sawle G,Björklund A,Brooks DJ,Marsden CD,Quinn NP,Lindvall O

    更新日期:1997-07-01 00:00:00

  • Selective neurodegeneration in murine mucopolysaccharidosis VII is progressive and reversible.

    abstract::The mucopolysaccharidoses are caused by inherited deficiencies of lysosomal enzymes involved in the degradative pathway of glycosaminoglycans. Lysosomal storage leads to cellular and organ dysfunction, including mental retardation. Storage lesions are found throughout the diseased brain, but little is known about the ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.10373

    authors: Heuer GG,Passini MA,Jiang K,Parente MK,Lee VM,Trojanowski JQ,Wolfe JH

    更新日期:2002-12-01 00:00:00

  • Abnormal unloading reflex in a patient with infarction of the medial lemniscus.

    abstract::The unloading reflex was measured in the intrinsic muscles of the hand. By removing various fractions of the load on the muscles, we determined the size of the electromyographic response as a function of the change in the external force. This technique was applied to both hands of a patient with a pontine lesion who h...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410130309

    authors: Angel RW,Goldstein M

    更新日期:1983-03-01 00:00:00

  • Bilateral carotid artery occlusion resulting from giant cell arteritis.

    abstract::A 65-year-old woman with subacute global deterioration of neurological function had bilateral occlusion of the internal carotid arteries demonstrated by angiography. Postmortem examination showed isolated giant cell arteritis involving the carotid siphon bilaterally. ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410150216

    authors: Howard GF 3rd,Ho SU,Kim KS,Wallach J

    更新日期:1984-02-01 00:00:00

  • Diffuse axonal injury and traumatic coma in the primate.

    abstract::Traumatic coma was produced in 45 monkeys by accelerating the head without impact in one of three directions. The duration of coma, degree of neurological impairment, and amount of diffuse axonal injury (DAI) in the brain were directly related to the amount of coronal head motion used. Coma of less than 15 minutes (co...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410120611

    authors: Gennarelli TA,Thibault LE,Adams JH,Graham DI,Thompson CJ,Marcincin RP

    更新日期:1982-12-01 00:00:00

  • Limitations of ultrasound in detecting cerebral ischemic lesions in the neonate.

    abstract::Ultrasound scans of three newborn infants with cerebral ischemic lesions demonstrated on computed tomographic scan showed unexpected changes in echogenicity of brain parenchyma in addition to lateralized mass effect. Areas of increased echogenicity were present adjacent to regions of infarction identified on computed ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410140212

    authors: Wilson-Davis SL,Lo W,Filly RA

    更新日期:1983-08-01 00:00:00

  • Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B.

    abstract::Imaging of cerebrovascular beta-amyloid (cerebral amyloid angiopathy) is complicated by the nearly universal overlap of this pathology with Alzheimer's pathology. We performed positron emission tomographic imaging with Pittsburgh Compound B on 42-year-old man with early manifestations of Iowa-type hereditary cerebral ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.21528

    authors: Greenberg SM,Grabowski T,Gurol ME,Skehan ME,Nandigam RN,Becker JA,Garcia-Alloza M,Prada C,Frosch MP,Rosand J,Viswanathan A,Smith EE,Johnson KA

    更新日期:2008-11-01 00:00:00

  • Marked age-dependent neuroprotection by brain-derived neurotrophic factor against neonatal hypoxic-ischemic brain injury.

    abstract::Hypoxic-ischemic brain injury in survivors of perinatal asphyxia is a frequently encountered clinical problem for which there is currently no effective therapy. Neurotrophins, such as brain-derived neurotrophic factor (BDNF), can protect responsive neurons against cell death in some injury paradigms. While the role of...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410410416

    authors: Cheng Y,Gidday JM,Yan Q,Shah AR,Holtzman DM

    更新日期:1997-04-01 00:00:00