Abstract:
:In vivo phosphorus nuclear magnetic resonance spectroscopy (31P NMR) was used to evaluate the pattern of phosphate compounds in seven newborn babies (mean gestational age, 32 weeks; birth weight, 1,430 gm; age, 37 days) with a history of perinatal asphyxia. Spectra were collected in a 1.9 Tesla superconductive magnet with surface coil techniques. The spectra had characteristic peaks for phosphorylated monoesters (PME), inorganic phosphate (Pi), phosphodiesters (PD), phosphocreatine (PCr), and ATP. In contrast to cortical spectra from mature animals, these newborn infant 31P NMR spectra were dominated by a large PME peak and had small PCr, Pi, and PD peaks. Intracellular pH, as measured from the chemical shift of the Pi peak relative to the PCr peak, was 7.1 +/- 0.1 (SD). We studied one infant postmortem, and a large PME peak was present in his spectrum. The presence of PME 3 hours after death strongly suggests that it is not a sugar phosphate. In NMR spectroscopy, compounds are identified by their chemical shift relative to a known standard (PCr); the chemical shift of the PME peak was 6.5 ppm, suggesting that it is a mixture of phosphoryl ethanolamine and phosphoryl choline. The PCr/Pi ratio (1.3 +/- 0.7) and the PCr/ATP ratio (0.7 +/- 0.4) were lower in these babies than in mature animals (greater than 2 and greater than 1.4, respectively); the PME/PD ratio (1.2 +/- 0.6), however, was much greater in the infants (mature animals, less than 0.2). These findings suggest that there are unique aspects of human newborn cerebral metabolites and bioenergetic reserve.
journal_name
Ann Neuroljournal_title
Annals of neurologyauthors
Younkin DP,Delivoria-Papadopoulos M,Leonard JC,Subramanian VH,Eleff S,Leigh JS Jr,Chance Bdoi
10.1002/ana.410160509subject
Has Abstractpub_date
1984-11-01 00:00:00pages
581-6issue
5eissn
0364-5134issn
1531-8249journal_volume
16pub_type
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journal_title:Annals of neurology
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doi:10.1002/ana.21680
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journal_title:Annals of neurology
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更新日期:1982-10-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410200214
更新日期:1986-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1977-10-01 00:00:00
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更新日期:2006-03-01 00:00:00
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更新日期:2018-05-01 00:00:00
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更新日期:2010-02-01 00:00:00
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更新日期:2005-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ana.10598
更新日期:2003-06-01 00:00:00
abstract::Authorship of scientific publications holds great importance for basic and clinical researchers. Academic appointments and promotions, grant funding, and salary support depend to some extent on published recognition through authorship. Peer-recognition and personal satisfaction are additional incentives for authorship...
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更新日期:2010-12-01 00:00:00
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doi:10.1002/ana.410170117
更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-12-01 00:00:00
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更新日期:2003-03-01 00:00:00
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更新日期:2018-08-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:1992-11-01 00:00:00
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更新日期:2015-12-01 00:00:00
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journal_title:Annals of neurology
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更新日期:2001-03-01 00:00:00
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更新日期:2017-05-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410310408
更新日期:1992-04-01 00:00:00