Abstract:
:Two principal features of Alzheimer's disease (AD) are (1) the occurrence of neurofibrillary tangles (NFTs) and senile plaques, and (2) the loss of cortical cholinergic activity because of dysfunction of neurons in the basal forebrain cholinergic system. The relationship of these two abnormalities is an unresolved issue in the pathology of AD. We used polyclonal antibodies specific for paired helical filaments (PHFs), combined with acetylcholinesterase (AChE) histochemistry, to assess the cytoskeletal changes of cholinergic and noncholinergic neurons in the basal forebrain in AD. In both sporadic and familial AD, the nucleus basalis of Meynert (nbM) showed a marked decrease in AChE-positive (AChE+) perikarya and abundant immunoreactive NFTs. In double-labeling studies of the nbM, PHF reactivity was found both in surviving AChE+ neurons and in many AChE- NFTs that were not associated with microscopically recognizable cell structures. Some surviving AChE+ perikarya did not contain NFTs. Numerous NFTs and senile plaques were identified by PHF immunoreactivity in other basal forebrain areas, including subnuclei of the amygdala that showed low or absent AChE activity. We conclude that the dysfunction and death of cholinergic neurons in the nbM is associated with extensive NFT formation, including apparently residual NFTs in loci where nbM neurons once existed; and many noncholinergic neurons and neurites in the basal forebrain show NFT and senile plaque formation. The cytopathology of AD involves neurons of varying transmitter specificities, including cholinergic neurons in the basal forebrain.
journal_name
Ann Neuroljournal_title
Annals of neurologyauthors
Rasool CG,Svendsen CN,Selkoe DJdoi
10.1002/ana.410200407subject
Has Abstractpub_date
1986-10-01 00:00:00pages
482-8issue
4eissn
0364-5134issn
1531-8249journal_volume
20pub_type
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:2005-05-01 00:00:00
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journal_title:Annals of neurology
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journal_title:Annals of neurology
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更新日期:2009-12-01 00:00:00
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journal_title:Annals of neurology
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journal_title:Annals of neurology
pub_type: 临床试验,杂志文章
doi:10.1002/ana.410410314
更新日期:1997-03-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.21644
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journal_title:Annals of neurology
pub_type: 杂志文章,评审
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更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ana.410410105
更新日期:1997-01-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410200612
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更新日期:2014-08-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410240204
更新日期:1988-08-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410440604
更新日期:1998-12-01 00:00:00
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doi:10.1002/ana.410440319
更新日期:1998-09-01 00:00:00
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journal_title:Annals of neurology
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更新日期:2020-10-01 00:00:00
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journal_title:Annals of neurology
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更新日期:1986-06-01 00:00:00
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更新日期:2012-04-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.21752
更新日期:2009-09-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410090310
更新日期:1981-03-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00