Abstract:
:A fundamental problem in neuroscience, to which Prof. Segundo has made seminal contributions, is to understand how action potentials represent events in the external world. The aim of this paper is to review the issue of neural coding in the context of the rodent whiskers, an increasingly popular model system. Key issues we consider are: the role of spike timing; mechanisms of spike timing; decoding and context-dependence. Significant insight has come from the development of rigorous, information theoretic frameworks for tackling these questions, in conjunction with suitably designed experiments. We review both the theory and experimental studies. In contrast to the classical view that neurons are noisy and unreliable, it is becoming clear that many neurons in the subcortical whisker pathway are remarkably reliable and, by virtue of spike timing with millisecond-precision, have high bandwidth for conveying sensory information. In this way, even small (approximately 200 neuron) subcortical modules are able to support the sensory processing underlying sophisticated whisker-dependent behaviours. Future work on neural coding in cortex will need to consider new findings that responses are highly dependent on context, including behavioural and internal states.
journal_name
Biol Cybernjournal_title
Biological cyberneticsauthors
Petersen RS,Panzeri S,Maravall Mdoi
10.1007/s00422-008-0290-5subject
Has Abstractpub_date
2009-06-01 00:00:00pages
427-46issue
6eissn
0340-1200issn
1432-0770journal_volume
100pub_type
杂志文章,评审abstract::The availability of a simple-to-use, automatic measurement system for noninvasive flow estimation is imperative, given the clinical demand for an acceptable noninvasive procedure rather than the standard invasive procedure of thermodilution. A method for calculating cardiac output from noninvasively derived pressure p...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s004220050372
更新日期:1997-08-01 00:00:00
abstract::A novel artificial neural network, derived from neurobiological observations, is described and examples of its performance are presented. This DYnamically STable Associative Learning (DYSTAL) network associatively learns both correlations and anticorrelations, and can be configured to classify or restore patterns with...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00197642
更新日期:1990-01-01 00:00:00
abstract::For the Ornstein-Uhlenbeck neuronal model a quantitative method is proposed for the estimation of the two parameters characterizing the unknown input process, namely the neuron's mean input per unit time mu and the infinitesimal standard deviation per unit time sigma. This method is based on the experimentally observe...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00201423
更新日期:1995-08-01 00:00:00
abstract::In many applications of signal processing, especially in communications and biomedicine, preprocessing is necessary to remove noise from data recorded by multiple sensors. Typically, each sensor or electrode measures the noisy mixture of original source signals. In this paper a noise reduction technique using independ...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-001-0298-6
更新日期:2002-04-01 00:00:00
abstract::A mathematical muscle model is presented that relates neural control signals linearly to muscle force without violating important known physiological constraints, such as the size-principle (Henneman and Mendell 1981) and non-linear twitch summation (Burke et al. 1976). This linearity implies that the neural control s...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00206220
更新日期:1991-01-01 00:00:00
abstract::A minimum mean square error (MMSE) estimation scheme is employed to identify the synaptic connectivity in neural networks. This new approach can substantially reduce the amount of data and the computational cost involved in the conventional correlation methods, and is suitable for both nonstationary and stationary neu...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00198088
更新日期:1991-01-01 00:00:00
abstract::In bursting excitable cells such as pancreatic beta-cells and molluscan Aplysia neuron cells, intracellular Ca2+ ion plays a central role in various cellular functions. To understand the role of [Ca2+]i (the intracellular Ca2+ concentration) in electrical bursting, we formulate a mathematical model which contains a fe...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00202449
更新日期:1990-01-01 00:00:00
abstract::Synchronization of the oscillatory discharge of cortical neurons could be a part of the mechanism that is involved in cortical information processing. On the assumption that the basic functional unit is the column composed of local excitatory and inhibitory cells and generating oscillatory neural activity, a network m...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00202761
更新日期:1994-01-01 00:00:00
abstract::The present paper examines human hand impedance characteristics, including inertia and viscosity as well as stiffness, in multi-joint arm movements. While a subject maintains a given hand location, small external disturbances are applied to his hand by a manipulandum. The corresponding force-displacement vectors are m...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00199890
更新日期:1995-01-01 00:00:00
abstract::Since the seminal works of Bernstein (The coordination and regulation of movements. Pergamon Press, Oxford, 1967) several authors have supported the idea that, to produce a goal-oriented movement in general, and a movement of the organs responsible for the production of speech sounds in particular, individuals activat...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-018-0749-y
更新日期:2018-06-01 00:00:00
abstract::In studies of human balance, it is common to fit stimulus-response data by tuning the time-delay and gain parameters of a simple delayed feedback model. Many interpret this fitted model, a simple delayed feedback model, as evidence that predictive processes are not required to explain existing data on standing balance...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-009-0325-6
更新日期:2009-08-01 00:00:00
abstract::Highly-interconnected networks of nonlinear analog neurons are shown to be extremely effective in computing. The networks can rapidly provide a collectively-computed solution (a digital output) to a problem on the basis of analog input information. The problems to be solved must be formulated in terms of desired optim...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00339943
更新日期:1985-01-01 00:00:00
abstract::Many tasks require the arm to move from its initial position to a specified target position, but leave us free to choose the trajectory between them. This paper presents and tests the hypothesis that trajectories are chosen to minimize metabolic energy costs. Costs are calculated for the range of possible trajectories...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s004220050324
更新日期:1997-02-01 00:00:00
abstract::The aim of this paper is to summarize and to compare some known mathematical models of orientation perception in random dot patterns and to propose new solutions of this question. The model adequacy is judged from the previously obtained experimental results. Apart from the models based on some simple function of the ...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00202455
更新日期:1990-01-01 00:00:00
abstract::Within the field of motor control, there is no consensus on which kinematic and kinetic aspects of movements are planned or controlled. Perturbing goal-directed movements is a frequently used tool to answer this question. To be able to draw conclusions about motor control from kinematic responses to perturbations, a m...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-012-0505-7
更新日期:2012-10-01 00:00:00
abstract::It is generally held that the right and left middle ears of mammals are acoustically isolated from each other, such that mammals must rely on neural computation to derive sound localisation cues. There are, however, some unusual species in which the middle ear cavities intercommunicate, in which case each ear might be...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-015-0675-1
更新日期:2016-10-01 00:00:00
abstract::A multisegment, multijoint model of a falling animal is presented to examine the effectiveness of a two-stage control scheme in a zero-momentum self-righting maneuver. The model contains a much larger number of degrees of freedom than is required to execute a self-righting maneuver and is thus capable of providing mul...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s004220050488
更新日期:1998-11-01 00:00:00
abstract::A new method is presented for quantitative evaluation of single-sweep phase and amplitude electro-encephalogram (EEG) characteristics that is a more informative approach in comparison with conventional signal averaging. In the averaged potential, phase-locking and amplitude effects of the EEG response cannot be separa...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s004220050335
更新日期:1997-03-01 00:00:00
abstract::Walking behavior is modulated by controlling joint torques in most existing passivity-based bipeds. Controlled Passive Walking with adaptable stiffness exhibits controllable natural motions and energy efficient gaits. In this paper, we propose torque-stiffness-controlled dynamic bipedal walking, which extends the conc...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-014-0625-3
更新日期:2014-12-01 00:00:00
abstract::The detection of small radially symmetric targets was studied using a subthreshold summation paradigm. Small disc and disc-like patterns with diameters up to 0.60 were used for superposition on Bessel functions of zero order, subthreshold contrast and various spatial frequencies. Contrast interrelation functions prove...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s004220170005
更新日期:2001-01-01 00:00:00
abstract::In the current research, the muscle equivalent linear damping coefficient which is introduced as the force-velocity relation in a muscle model and the corresponding time constant are investigated. In order to reach this goal, a 1D skeletal muscle model was used. Two characterizations of this model using a linear force...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-016-0680-z
更新日期:2016-02-01 00:00:00
abstract::To investigate the dynamic effects of external forces on the displacement of the otolith membrane and subsequent neuronal responses of otoliths, we performed numerical analyses of otolith membrane displacements. In these studies we included the full geometry of the human otolith maculae, including their 3D curvature. ...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-003-0456-0
更新日期:2004-03-01 00:00:00
abstract::Stable signal transmission is crucial for information processing by the brain. Synfire-chains, defined as feed-forward networks of spiking neurons, are a well-studied class of circuit structure that can propagate a packet of single spikes while maintaining a fixed packet profile. Here, we studied the stable propagatio...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-008-0246-9
更新日期:2008-08-01 00:00:00
abstract::Flies have the capability to visually track small moving targets, even across cluttered backgrounds. Previous computational models, based on figure detection (FD) cells identified in the fly, have suggested how this may be accomplished at a neuronal level based on information about relative motion between the target a...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-004-0518-y
更新日期:2004-12-01 00:00:00
abstract::Rapidly adapting (RA) currents expressed in dorsal root ganglia somatosensory neurons reduce their amplitude in response to prolonged and/or repeated mechanical stimulation. Both inactivation of mechanotransducer channels and adaptation of the force acting on the channels have been suggested to independently decrease ...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-016-0693-7
更新日期:2016-12-01 00:00:00
abstract::Systems that generate spike outputs in response to continuous inputs abound in neurophysiology. The study of their dynamics with the use of systems analysis methods has been complicated by the difference in modality of the input and output signals. When the problem is placed in the framework of Wiener's theory in disc...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00320482
更新日期:1986-01-01 00:00:00
abstract::We propose a function-oriented model of the visual cortex. The model addresses an essential task of the visual system: to detect and represent objects. These are defined as sets, which reappear in the input with invariant inner relations. A network, incorporating an idealized description of anatomical and physiologica...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF02414887
更新日期:1992-01-01 00:00:00
abstract::We report on the ability of human observers in judging their direction of translation from sparse, moving random dot patterns for varying extents of 3--D rotation. The observers have to discriminate possible axes of translation with angular separations of 2.5 deg or 5 deg. The field of view is either 20 X 20 deg or 10...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00449594
更新日期:1985-01-01 00:00:00
abstract::It is shown that a convolution with certain reasonable receptive field (RF) profiles yields the exact partial derivatives of the retinal illuminance blurred to a specified degree. Arbitrary concatenations of such RF profiles yield again similar ones of higher order and for a greater degree of blurring. By replacing th...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00318371
更新日期:1987-01-01 00:00:00
abstract::The frequency sensitivity of weak periodic signal detection has been studied via numerical simulations for both a single neuron and a neuronal network. The dependence of the critical amplitude of the signal upon its frequency and a resonance between the intrinsic oscillations of a neuron and the signal could account f...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s004220000203
更新日期:2001-03-01 00:00:00