Abstract:
:A minimum mean square error (MMSE) estimation scheme is employed to identify the synaptic connectivity in neural networks. This new approach can substantially reduce the amount of data and the computational cost involved in the conventional correlation methods, and is suitable for both nonstationary and stationary neuronal firings. Two algorithms are proposed to estimate the synaptic connectivities recursively, one for nonlinear filtering, the other for linear filtering. In addition, the lower and upper bounds for the MMSE estimator are determined. It is shown that the estimators are consistent in quadratic mean. We also demonstrate that the conventional cross-interval histogram is an asymptotic linear MMSE estimator with an inappropriate initial value. Finally, simulations of both nonlinear and linear (Kalman filter) estimate demonstrate that the true connectivity values are approached asymptotically.
journal_name
Biol Cybernjournal_title
Biological cyberneticsauthors
Yang X,Shamma SAdoi
10.1007/BF00198088subject
Has Abstractpub_date
1991-01-01 00:00:00pages
171-9issue
3eissn
0340-1200issn
1432-0770journal_volume
65pub_type
杂志文章abstract::Movement of multiple segment limbs requires generation of appropriate joint torques which include terms arising from dynamic interactions among the moving segments as well as from such external forces as gravity. The interaction torques, arising from inertial, centripetal, and Coriolis forces, are not present for sing...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00353957
更新日期:1982-01-01 00:00:00
abstract::Since the seminal works of Bernstein (The coordination and regulation of movements. Pergamon Press, Oxford, 1967) several authors have supported the idea that, to produce a goal-oriented movement in general, and a movement of the organs responsible for the production of speech sounds in particular, individuals activat...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-018-0749-y
更新日期:2018-06-01 00:00:00
abstract::We develop a novel optimal control algorithm to change the phase of an oscillator using a minimum energy input, which also minimizes the oscillator's transversal distance to the uncontrolled periodic orbit. Our algorithm uses a two-dimensional reduction technique based on both isochrons and isostables. We develop a no...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-018-0764-z
更新日期:2019-04-01 00:00:00
abstract::We extend a quantitative model for low-voltage, slow-wave excitability based on the T-type calcium current (Wang et al. 1991) by juxtaposing it with a Hodgkin-Huxley-like model for fast sodium spiking in the high voltage regime to account for the distinct firing modes of thalamic neurons. We employ bifurcation analysi...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00239616
更新日期:1994-01-01 00:00:00
abstract::This paper concerns the use of tracking studies to test a theoretical account of the information processing performed by the human CNS during control of movement. The theory provides a bridge between studies of reaction time and continuous tracking. It is proposed that the human CNS includes neuronal circuitry to comp...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00364156
更新日期:1988-01-01 00:00:00
abstract::The conductance-based refractory density (CBRD) approach is an efficient tool for modeling interacting neuronal populations. The model describes the firing activity of a statistical ensemble of uncoupled Hodgkin-Huxley-like neurons, each receiving individual Gaussian noise and a common time-varying deterministic input...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-017-0727-9
更新日期:2017-12-01 00:00:00
abstract::We consider the description of a nonlinear stochastic transduction in terms of its input/output distribution. We construct a sequence of approximating maximum-entropy estimates from a finite set of input/output observations. This procedure extends the Wiener theory to the analysis of nonlinear stochastic transducers a...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00318425
更新日期:1986-01-01 00:00:00
abstract::The stoichiometric and kinetic details of transmitter-receptor interaction (the number of conformations and the rate constants of conformation changes( in synaptic transmission have been investigated analyzing postsynaptic membrane noises by the aid of the fluctuation-dissipation theorem of stochastic chemical kinetic...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00337450
更新日期:1979-02-02 00:00:00
abstract::The correspondence between afferent discharges and sinusoidal length modulations (0.2--10 cps, under 10% of the natural length variations) was studied in isolated fast-adapting stretch receptor organs (FAO) of crayfish, largely using average displays of rate vs. length (or derivatives) along the cycle. Rate modulation...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00336926
更新日期:1983-01-01 00:00:00
abstract::A new association scheme which can still recall appropriate data when some key elements are missing (blank) is presented. The traditional associative memory models are designed to deal with complete (memorized) keys, but in the real world, key elements are often missing due to error, equipment failure, observation dif...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00317975
更新日期:1982-01-01 00:00:00
abstract::Fast as possible (time optimal) single joint movements throughout the body are characterized by the triphasic (3 pulse) pattern of activation in the agonist and antagonist muscles. Simulation studies using a sixth order, non-linear model were undertaken to determine the relationship between time optimal movement and t...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00338824
更新日期:1987-01-01 00:00:00
abstract::Flies have the capability to visually track small moving targets, even across cluttered backgrounds. Previous computational models, based on figure detection (FD) cells identified in the fly, have suggested how this may be accomplished at a neuronal level based on information about relative motion between the target a...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-004-0518-y
更新日期:2004-12-01 00:00:00
abstract::Isolated and cultured neonatal cardiac myocytes contract spontaneously and cyclically, and have the properties of a non-linear oscillator. In this study, we have analyzed the relationship between the fluctuation of contraction rhythm of spontaneously beating cultured cardiac myocytes, and the coupling strength among t...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-001-0285-y
更新日期:2002-02-01 00:00:00
abstract::Stable signal transmission is crucial for information processing by the brain. Synfire-chains, defined as feed-forward networks of spiking neurons, are a well-studied class of circuit structure that can propagate a packet of single spikes while maintaining a fixed packet profile. Here, we studied the stable propagatio...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-008-0246-9
更新日期:2008-08-01 00:00:00
abstract::A system of coupled bistable Hopf oscillators with an external periodic input source was used to model the ability of interacting neural populations to synchronize and desynchronize in response to variations of the input signal. We propose that, in biological systems, the settings of internal and external coupling str...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s004220050023
更新日期:2000-03-01 00:00:00
abstract::Response patterns recorded with 30 microelectrodes from area 17 of anaesthetized monkeys are analysed. A proportion of the patterns are used to define prototype response patterns. These in turn are used to recognize the stimulus from further non-averaged response patterns. In comparison, recognition by a feedforward '...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00194921
更新日期:1996-04-01 00:00:00
abstract::Neurons in sensory cortices are often assumed to be "feature detectors", computing simple and then successively more complex features out of the incoming sensory stream. These features are somehow integrated into percepts. Despite many years of research, a convincing candidate for such a feature in primary auditory co...
journal_title:Biological cybernetics
pub_type: 杂志文章,评审
doi:10.1007/s00422-003-0445-3
更新日期:2003-11-01 00:00:00
abstract::This paper develops a novel control system for functional electrical stimulation (FES) locomotion, which aims to generate normal locomotion for paraplegics via FES. It explores the possibility of applying ideas from biology to engineering. The neural control mechanism of the biological motor system, the central patter...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-006-0107-3
更新日期:2007-01-01 00:00:00
abstract::A neural model is proposed for the spatiotemporal properties of simple cells in the visual cortex. In the model, several cortical cells are arranged on a ring, with mutual excitatory or inhibitory connections. The cells also receive excitatory inputs either from lagged and nonlagged cells of the lateral geniculate nuc...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s004220050383
更新日期:1997-10-01 00:00:00
abstract::It is shown how field potentials due to neuronal membrane processes can be computed by means of a digital computer system. The essence of the method consists in evaluating a discrete expression for the field potential as a function of membrane potentials. This expression is considered as a three-dimensional convolutio...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00347640
更新日期:1980-01-01 00:00:00
abstract::Reported here are the results from two experiments designed to investigate Mateeff and Gourevich's (1983, 1984) claim that adult observers make large constant errors when judging the direction of briefly presented peripheral targets, with respect to a continuously visible scale. Experiment 1 involved a virtually exact...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00204123
更新日期:1989-01-01 00:00:00
abstract::There are interesting oscillatory phenomena associated with excitable cells that require theoretical insight. Some of these phenomena are: the threshold low amplitude oscillations before bursting in neuronal cells, the damped burst observed in muscle cells, the period-adding bifurcations without chaos in pancreatic be...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00198918
更新日期:1994-01-01 00:00:00
abstract::We present a general neural model for supervised learning of pattern categories which can resolve pattern classes separated by nonlinear, essentially arbitrary boundaries. The concept of a pattern class develops from storing in memory a limited number of class elements (prototypes). Associated with each prototype is a...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00387211
更新日期:1982-01-01 00:00:00
abstract::Neurons transmit information as action potentials or spikes. Due to the inherent randomness of the inter-spike intervals (ISIs), probabilistic models are often used for their description. Cumulative damage (CD) distributions are a family of probabilistic models that has been widely considered for describing time-relat...
journal_title:Biological cybernetics
pub_type: 杂志文章,评审
doi:10.1007/s00422-015-0651-9
更新日期:2015-10-01 00:00:00
abstract::In primates, it is well known that there is a consistent relationship between the duration, peak velocity and amplitude of saccadic eye movements, known as the 'main sequence'. The reason why such a stereotyped relationship evolved is unknown. We propose that a fundamental constraint on the deployment of foveal vision...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-006-0064-x
更新日期:2006-07-01 00:00:00
abstract::Simulations of neural activity are commonly based on differential equations. We address the question what can be achieved with a simplified discrete model. The proposed model resembles artificial neural networks enriched with additional biologically inspired features. A neuron has several states, and the state transit...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-020-00826-w
更新日期:2020-06-01 00:00:00
abstract::In vision of everyday scenes, features requiring detection are frequently observed in the presence of suprathreshold background structures. Detection of such features is a contrast discrimination task and is often necessary for the subsequent process of recognition. In order to provide a description of this task, cont...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00326678
更新日期:1981-01-01 00:00:00
abstract::Between the extreme views concerning ontogenesis (genetic vs. environmental determination), we use a moderate approach: a somehow pre-established neuronal model network reacts to activity deviations (reflecting input to be compensated), and stabilizes itself during a complex feed-back process. Morphogenesis is based o...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00318417
更新日期:1986-01-01 00:00:00
abstract::Brain resonance phenomena and induced rhythms in the brain recently gained importance in electroencephalographic, magnetoencephalographic and cellular studies (Başar and Bullock 1992). It was hypothesized that evoked potentials are superpositions of induced rhythms caused by resonance phenomena in neural populations (...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00205980
更新日期:1994-01-01 00:00:00
abstract::A receptive field constitutes a region in the visual field where a visual cell or a visual operator responds to visual stimuli. This paper presents a theory for what types of receptive field profiles can be regarded as natural for an idealized vision system, given a set of structural requirements on the first stages o...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-013-0569-z
更新日期:2013-12-01 00:00:00