Role of the cholinergic system in the pathology and treatment of schizophrenia.

abstract：:Cognitive dysfunction (CD) affects 40-65% of multiple sclerosis (MS) patients and can have a great functional impact. It can be detected in all the disease phenotypes from the early stages of the disease and tends to progress over time. Memory, complex attention, information processing speed and executive functions ar...

journal_title：Expert review of neurotherapeutics

authors： Amato MP,Zipoli V,Portaccio E

更新日期：2008-10-01 00:00:00

abstract：INTRODUCTION:Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS). The modern treatment era for MS witnessed a growing pool of drugs now available for use in clinical practice. These therapies work at different levels, however there is a lack of treatments acting on the neurode...

journal_title：Expert review of neurotherapeutics

authors： Ruggieri S,Tortorella C,Gasperini C

更新日期：2017-11-01 00:00:00

abstract：:Introduction: Headache is the fifth most common reason to visit an emergency department (ED). In most of the cases, headache is benign and has a primary origin, with migraine as the most common diagnosis. Inappropriate use of ED for non-emergency conditions causes overcrowding, unnecessary testing, and increased medic...

journal_title：Expert review of neurotherapeutics

authors： Luciani M,Negro A,Spuntarelli V,Bentivegna E,Martelletti P

更新日期：2021-01-04 00:00:00

abstract：:Chronic inflammatory demyelinating polyradiculoneuropathy is a neuromuscular disorder for which immunological factors are undoubtedly important in the etiopathogenesis. As clinical recognition of this disorder has improved, immunosuppressive and immunomodulating treatments have emerged as the treatments of choice and ...

journal_title：Expert review of neurotherapeutics

authors： Kaplan RL,Albers JW

更新日期：2003-03-01 00:00:00

abstract：:Genetic analysis is providing new information on the biological basis of epilepsy at a rapid pace; this article identifies factors acting as major barriers to use of these data for therapy development. Disease heterogeneity is a primary obstacle since so many genes can cause or predispose to epilepsy and the clinical ...

journal_title：Expert review of neurotherapeutics

authors： Ferraro TN

更新日期：2016-01-01 00:00:00

abstract：:Introduction: Alzheimer's Disease (AD) is a progressive neurodegenerative pathology characterized by the presence of neuritic plaques and neurofibrillary tangles. The most important markers in AD pathology include excessive accumulation of amyloid beta (Aβ42) and phosphorylated tau (P-tau) proteins. One of the possibl...

journal_title：Expert review of neurotherapeutics

authors： Baranowska-Wójcik E,Szwajgier D

更新日期：2020-03-01 00:00:00

abstract：:Lennox-Gastaut syndrome is a relatively rare epilepsy syndrome that usually begins in early-mid childhood and is characterized by multiple seizure types, particularly generalized seizures, which are often resistant to antiepileptic drug medication. Rufinamide is a new antiepileptic drug approved as adjunctive therapy ...

journal_title：Expert review of neurotherapeutics

authors： Ferrie CD

更新日期：2010-06-01 00:00:00

abstract：INTRODUCTION:Chronic inflammatory neuropathies are disorders caused by an immune response to peripheral nerve. They include chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and neuropathy associated with anti-MAG IgM monoclonal gammopathy and other less frequent neurop...

journal_title：Expert review of neurotherapeutics

authors： Nobile-Orazio E,Gallia F,Terenghi F,Bianco M

更新日期：2017-08-01 00:00:00

abstract：:The increasing prevalence of chronic pain with its major societal impact and the escalating use of opioids in managing it, along with their misuse, abuse, associated fatalities and costs, are epidemics in modern medicine. Over the past two decades, multiple lessons have been learned addressing various issues of abuse....

journal_title：Expert review of neurotherapeutics

authors： Manchikanti L,Boswell MV,Hirsch JA

更新日期：2013-05-01 00:00:00

abstract：INTRODUCTION:Spinal muscular atrophy (SMA) is an autosomal recessive degenerative neuromuscular disorder characterized by loss of spinal motor neurons leading to muscle weakness. This review article focuses on a novel antisense oligonucleotide treatment, first ever approved for SMA (nusinersen, SpinrazaTM) and describe...

journal_title：Expert review of neurotherapeutics

authors： Chiriboga CA

更新日期：2017-10-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive and generally well-tolerated method of focally stimulating brain regions. It has been shown to be efficacious in the treatment for depression, but only to a limited degree. It has also been investigated for the treatment of some anxiety disorders, pa...

journal_title：Expert review of neurotherapeutics

authors： Pigot M,Loo C,Sachdev P

更新日期：2008-10-01 00:00:00

abstract：:Introduction: Almotriptan (ALT), a serotonin 5-HT1B/1D agonist has been used in the acute treatment of migraine with or without aura for 20 years, accumulating data on more than 15,000 patients in studies and from an estimated >150 million treated migraine attacks in daily clinical practice. The last major review of A...

journal_title：Expert review of neurotherapeutics

authors： Pascual J,Vila C

更新日期：2019-08-01 00:00:00

abstract：:Estrogens fluctuations, particularly their premenstrual fall, are currently regarded as the main triggers of menstrual migraine (MM). MM presents in two clinical forms: pure MM, where attacks are confined to the perimenstrual period (PMP), and menstrually related migraine, where attacks always occur during, but are no...

journal_title：Expert review of neurotherapeutics

authors： Allais G,Castagnoli Gabellari I,De Lorenzo C,Mana O,Benedetto C

更新日期：2007-09-01 00:00:00

abstract：:Understanding of the structure and function of the endocannabinoid system is rapidly evolving. Physiological and pharmacological manipulations based on cannabinoid receptors, ligands and endocannabinoids have explained some medicinal attributes of cannabinoids as used across the world for thousands of years. Plant-der...

journal_title：Expert review of neurotherapeutics

authors： Holdcroft A,Patel P

更新日期：2001-09-01 00:00:00

abstract：:The saga of harmful administration of levodopa (LD) in the treatment of Parkinson's disease (PD) resulted from outcomes of animal trials and cell culture studies. They were initiated after the clinical observation of onset of motor complications related to the short plasma half-life of the drug in PD patients. This di...

journal_title：Expert review of neurotherapeutics

authors： Müller T

更新日期：2008-06-01 00:00:00

abstract：:Glatiramer acetate (GA; Copaxone(®), Teva Pharmaceuticals Inc.), approved in the USA in 1996 and EU in 2001 as first-line treatment for relapsing-remitting multiple sclerosis, is now available in 51 countries and recently gained approval for delaying conversion to clinically definite multiple sclerosis in patients wit...

journal_title：Expert review of neurotherapeutics

authors： Johnson KP

更新日期：2012-04-01 00:00:00

abstract：:Dystonia may be a sign or symptom, that is comprised of complex abnormal and dynamic movements of different etiologies. A specific cause is identified in approximately 28% of patients, which only occasionally results in specific treatment. In most cases, treatment is symptomatic and designed to relieve involuntary mov...

journal_title：Expert review of neurotherapeutics

authors： Bhidayasiri R,Tarsy D

更新日期：2006-06-01 00:00:00

abstract：UNLABELLED:Pediatric bipolar disorder (PBD) presents with severe affect dysregulation characterized by elated mood, irritability and depressive symptoms, often in the form of a mixed episode. Early recognition of the external clinical features and the underlying emotional processing circuitry will help us understand th...

journal_title：Expert review of neurotherapeutics

authors： Pavuluri MN,Passarotti A

更新日期：2008-09-01 00:00:00

abstract：:Neurostimulation therapy involves the use of peripheral or central nerve electrical stimulation approaches for the treatment of medically intractable headache. Currently, for peripheral stimulation the main approach is that of occipital nerve stimulation, while for central stimulation deep-brain approaches with the ta...

journal_title：Expert review of neurotherapeutics

authors： Goadsby PJ

更新日期：2007-12-01 00:00:00

abstract：:Memory problems are generally quite prominent in dementia and they have a significant impact on everyday functioning. Medication developed for Alzheimer's disease, for example, acetylcholinesterase inhibitors, can slow down the increase of cognitive impairment for a while. In addition to pharmacotherapy, psychosocial ...

journal_title：Expert review of neurotherapeutics

authors： Dröes RM,van der Roest HG,van Mierlo L,Meiland FJ

更新日期：2011-12-01 00:00:00

abstract：:Median survival of patients with malignant glioma (MG) from time of diagnosis is approximately 1 year, despite surgery, irradiation and conventional chemotherapy. Improving patient outcome relies on our ability to develop more effective therapies that are directed against the unique molecular aberrations within a pati...

journal_title：Expert review of neurotherapeutics

authors： Thaker NG,Pollack IF

更新日期：2009-12-01 00:00:00

abstract：:Major depression and depressive symptoms are highly prevalent and there is a need for different forms of psychological treatments that can be delivered from a distance at a low cost. In the present review the authors contrast face-to-face and Internet-delivered cognitive behavior therapy (ICBT) for depression. A total...

journal_title：Expert review of neurotherapeutics

authors： Andersson G,Topooco N,Havik O,Nordgreen T

更新日期：2016-01-01 00:00:00

abstract：:Research has shown that structural variation in the human genome, including rare copy number variations (CNVs), contributes to genetic susceptibility to psychiatric diseases, such as schizophrenia, a devastating complex disorder with a high genetic load. The study by Vacic et al. applied a genome-wide approach to dete...

journal_title：Expert review of neurotherapeutics

authors： Nieratschker V,Meyer-Lindenberg A,Witt SH

更新日期：2011-07-01 00:00:00

abstract：:Sumatriptan 85 mg with naproxen sodium 500 mg, a combination tablet for the acute treatment of migraine, is approved in the USA. It is likely that triptan/NSAID combination benefits are a class effect, although the majority of data are on sumatriptan and naproxen sodium. The combination tablet demonstrated superior ef...

journal_title：Expert review of neurotherapeutics

authors： Cleves C,Tepper SJ

更新日期：2008-09-01 00:00:00

abstract：INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron degeneration in the brain and spinal cord. Treatment development for ALS is complicated by complex underlying disease factors. Areas covered: Numerous tested drug compounds have shown no benefits in ALS p...

journal_title：Expert review of neurotherapeutics

authors： Garbuzova-Davis S,Thomson A,Kurien C,Shytle RD,Sanberg PR

更新日期：2016-12-01 00:00:00

abstract：:Cortical spreading depression (CSD) has been at the center stage of migraine pathophysiology for approximately six decades. Reanalysis of CSD reveals several major unbridgeable gaps in this experimental neurophysiologic concept for migraine. Key phenotypic and pharmacological features of migraine challenge the assumed...

journal_title：Expert review of neurotherapeutics

authors： Gupta VK

更新日期：2009-11-01 00:00:00

abstract：:Attention deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder characterized by symptoms of inattention, hyperactivity and impulsivity. There is an ongoing discussion whether symptoms of emotional dysregulation should be added to the conceptualization of ADHD in order to describe the psychopathology ...

journal_title：Expert review of neurotherapeutics

authors： Retz W,Stieglitz RD,Corbisiero S,Retz-Junginger P,Rösler M

更新日期：2012-10-01 00:00:00

abstract：:There is great concern over cardiovascular disease in the schizophrenic population owing to the high incidence of cardiovascular mortality. Increased cardiovascular mortality is related to lifestyle choices (e.g., smoking and sedentary lifestyle) and a high prevalence of comorbid medical conditions, including dyslipid...

journal_title：Expert review of neurotherapeutics

authors： Michelsen JW,Meyer JM

更新日期：2007-07-01 00:00:00

abstract：:With advances in stereotactic and neuroimaging techniques, various minimally invasive image-guided techniques have gained widespread acceptance in the field of neuro-oncology. Laser interstitial thermal therapy (LITT) is an image-guided technique that involves generation of high temperatures using a laser fiber, to ab...

journal_title：Expert review of neurotherapeutics

authors： Sharma M,Balasubramanian S,Silva D,Barnett GH,Mohammadi AM

更新日期：2016-01-01 00:00:00

abstract：:Central pain, which follows brain and spinal cord injury remains an ill-treated entity affecting approximately 1-2 million people worldwide. When oral drugs fail, either immediately or in the long run, the only therapeutic option is neuromodulation, via either electrical or chemical means. The whole spectrum of neurom...

journal_title：Expert review of neurotherapeutics

authors： Canavero S,Bonicalzi V

更新日期：2003-09-01 00:00:00