CSD, BBB and MMP-9 elevations: animal experiments versus clinical phenomena in migraine.

abstract：:Introduction: Alzheimer's disease (AD), a commonly encountered neurodegenerative disorder, causes cognitive decline and has a devastating effect on the quality of life. AD occurs mainly through abnormal amyloid β peptide (Aβ) and tau protein (tau) activity around/in neurons. Aβ-based therapeutic techniques have been s...

journal_title：Expert review of neurotherapeutics

authors： Kuo YC,Rajesh R

更新日期：2019-07-01 00:00:00

abstract：:Cyclooxygenase-2 specific inhibitors have anti-inflammatory and analgesic properties, and are effective in managing a wide range of chronic and acute painful conditions such as adult rheumatoid arthritis, osteoarthritis, migraine, primary dysmenorrhea and postoperative pain. Valdecoxib, an orally administered cyclooxy...

journal_title：Expert review of neurotherapeutics

authors： Joshi GP

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Patients with multiple sclerosis (MS) may suffer from spasticity and pain during their disease course. Baclofen, dantrolene, diazepam and gabapentin have been used as first-line options to treat these conditions, with modest results. Medical use of marijuana smoking has bypassed traditional clinical trials...

journal_title：Expert review of neurotherapeutics

authors： Fragoso YD,Carra A,Macias MA

更新日期：2020-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is a prevalent and currently incurable brain disease whose impact will continue to rise as the population ages. With limited treatment options, a variety of experimental therapies are currently in clinical trials. EVP-6124 (encenicline) is an α7 nicotinic acetylcholine receptor partial agonist...

journal_title：Expert review of neurotherapeutics

authors： Deardorff WJ,Shobassy A,Grossberg GT

更新日期：2015-01-01 00:00:00

abstract：:Alzheimer's disease is the most common form of neurodegenerative dementia and poses considerable health challenges to both patients and their families. Rivastigmine is a powerful slow-reversible, noncompetitive carbamate cholinesterase inhibitor that is approved for the treatment of mild-to-moderate Alzheimer's diseas...

journal_title：Expert review of neurotherapeutics

authors： Desai AK,Grossberg GT

更新日期：2005-09-01 00:00:00

abstract：INTRODUCTION:The underlying etiology of tension type headache (TTH) is not understood. The current paper highlights the etiologic role of muscle trigger points (TrPs) to the development and maintenance of central sensitization in TTH and its clinical repercussion for proper management of these patients. Areas covered: ...

journal_title：Expert review of neurotherapeutics

authors： Fernández-De-Las-Peñas C,Arendt-Nielsen L

更新日期：2017-09-01 00:00:00

abstract：:Pain is one of the most troublesome sequelae of stroke, occurring in 19-74% of patients. A portion of this post-stroke pain is caused by the brain lesion itself; this is called 'central post-stroke pain' (CPSP). Although the prevalence of CPSP among stroke patients is low (1-8%), the persistent, often treatment-refrac...

journal_title：Expert review of neurotherapeutics

authors： Kim JS

更新日期：2009-05-01 00:00:00

abstract：:Sumatriptan subcutaneous administration is the fastest and most effective of the triptans for relief of acute migraine headache. This occurs even when the patient has already developed symptoms related to central sensitization, a key parameter in determining the effectiveness of these agents. In patients whose migrain...

journal_title：Expert review of neurotherapeutics

authors： Freitag FG

更新日期：2011-04-01 00:00:00

abstract：:Background: Triptanophobia is the excessive and inadequately justified concern about potential risks of triptans. We evaluated causes and consequences of nonuse of triptans in chronic migraine (CM) Methods: Case-control study. We included CM patients firstly referred to aheadache unit. Patients were cases or controls ...

journal_title：Expert review of neurotherapeutics

authors： Martínez-Pías E,García-Azorín D,Minguez-Olaondo A,Trigo J,Sierra Á,Ruiz M,Guerrero ÁL

更新日期：2021-01-01 00:00:00

abstract：:Central pain, which follows brain and spinal cord injury remains an ill-treated entity affecting approximately 1-2 million people worldwide. When oral drugs fail, either immediately or in the long run, the only therapeutic option is neuromodulation, via either electrical or chemical means. The whole spectrum of neurom...

journal_title：Expert review of neurotherapeutics

authors： Canavero S,Bonicalzi V

更新日期：2003-09-01 00:00:00

abstract：:Anaplastic glioma (AG) is divided into three morphology-based groups (anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma) as well as three molecular groups (glioma-CpG island methylation phenotype [G-CIMP] negative, G-CIMP positive non-1p19q codeleted tumors and G-CIMP positive codeleted...

journal_title：Expert review of neurotherapeutics

authors： Le Rhun E,Taillibert S,Chamberlain MC

更新日期：2015-06-01 00:00:00

abstract：:Spontaneous (non-traumatic) symptomatic intracerebral hemorrhage is a devastating form of stroke, with very high overall mortality and morbidity. Even with the best current medical or surgical treatment, outcomes still remain poor. By contrast with ischemic stroke, the incidence of intracerebral hemorrhage is not decr...

journal_title：Expert review of neurotherapeutics

authors： Wilson D,Charidimou A,Werring DJ

更新日期：2014-06-01 00:00:00

abstract：:With increasing life expectancy, the early diagnosis and treatment of Alzheimer's disease has become critical in sustaining a healthy society. Noninvasive markers of disease progression starting from the earliest stages of pathologic involvement are required for determining the effectiveness of putative disease-modify...

journal_title：Expert review of neurotherapeutics

authors： Kantarci K

更新日期：2005-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia and is characterized by an insidious onset and slow deterioration in cognition, activities of daily living (ADL), mood stability and social functioning. The cholinesterase inhibitors (ChEIs), developed based on the cholinergic hypothesis, are currently cons...

journal_title：Expert review of neurotherapeutics

authors： Tsuno N

更新日期：2009-05-01 00:00:00

abstract：:Epilepsy is the most common serious neurological disorder in the elderly after stroke and dementia. It may be more important for elderly people because it is intermittent and unpredictable. There is no reliable diagnostic test and so its diagnosis and management requires clinical acumen and experience. The situation i...

journal_title：Expert review of neurotherapeutics

authors： Johnston A,Smith PE

更新日期：2010-12-01 00:00:00

abstract：:Neurostimulation therapy involves the use of peripheral or central nerve electrical stimulation approaches for the treatment of medically intractable headache. Currently, for peripheral stimulation the main approach is that of occipital nerve stimulation, while for central stimulation deep-brain approaches with the ta...

journal_title：Expert review of neurotherapeutics

authors： Goadsby PJ

更新日期：2007-12-01 00:00:00

abstract：INTRODUCTION:The increasing development and availability of portable and wearable technologies is rapidly expanding the field of technology-based objective measures (TOMs) in neurological disorders, including Parkinson disease (PD). Substantial challenges remain in the recognition of disease phenomena relevant to patie...

journal_title：Expert review of neurotherapeutics

authors： Merola A,Sturchio A,Hacker S,Serna S,Vizcarra JA,Marsili L,Fasano A,Espay AJ

更新日期：2018-11-01 00:00:00

abstract：:Research into what works in depression is in trouble. All treatments appear equally effective and what happens in research trials does not seem to translate into clinical practice or, to put it another way, clinical practice is not reflected in randomized controlled trials. We run the risk of designing cosmetic trials...

journal_title：Expert review of neurotherapeutics

authors： Hatcher S

更新日期：2006-01-01 00:00:00

abstract：:The most successful approach for treating people with Alzheimer's disease to date has been by improving cholinergic transmission using cholinesterase inhibitors. Many of these drugs selectively inhibit acetylcholinesterase but some agents inhibit both acetylcholinesterase and butyrylcholinesterase. Recent evidence fro...

journal_title：Expert review of neurotherapeutics

authors： Tasker A,Perry EK,Ballard CG

更新日期：2005-01-01 00:00:00

abstract：:Major depression and depressive symptoms are highly prevalent and there is a need for different forms of psychological treatments that can be delivered from a distance at a low cost. In the present review the authors contrast face-to-face and Internet-delivered cognitive behavior therapy (ICBT) for depression. A total...

journal_title：Expert review of neurotherapeutics

authors： Andersson G,Topooco N,Havik O,Nordgreen T

更新日期：2016-01-01 00:00:00

abstract：:In different study populations, several studies have shown that modest C-reactive protein elevation, in the range of apparently healthy individuals, is a strong predictor of future vascular events. Willcox and colleagues summarize the epidemiological and clinical observations that have led to the enthusiastic suggesti...

journal_title：Expert review of neurotherapeutics

authors： Di Napoli M,Papa F

更新日期：2004-07-01 00:00:00

abstract：INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron degeneration in the brain and spinal cord. Treatment development for ALS is complicated by complex underlying disease factors. Areas covered: Numerous tested drug compounds have shown no benefits in ALS p...

journal_title：Expert review of neurotherapeutics

authors： Garbuzova-Davis S,Thomson A,Kurien C,Shytle RD,Sanberg PR

更新日期：2016-12-01 00:00:00

abstract：:This article proposes a revision of the historical evolution of the concepts of generalized anxiety disorder (GAD). Currently, Darwin's evolutionary theory is the hegemonic paradigm for modern science and influences research on mental disorders. Throughout the 20th Century, the editions of the Diagnostic and Statistic...

journal_title：Expert review of neurotherapeutics

authors： Coutinho FC,Dias GP,do Nascimento Bevilaqua MC,Gardino PF,Pimentel Rangé B,Nardi AE

更新日期：2010-08-01 00:00:00

abstract：INTRODUCTION:Therapy with current antiepileptic drugs aims at reducing the likelihood of seizure occurrence rather than influencing the underlying disease process. Therefore, antiepileptic drugs have an anticonvulsant rather than antiepileptic property. Areas covered: The increasing identification of genetic causes for...

journal_title：Expert review of neurotherapeutics

authors： Reif PS,Tsai MH,Helbig I,Rosenow F,Klein KM

更新日期：2017-04-01 00:00:00

abstract：:Introduction: Headache is the fifth most common reason to visit an emergency department (ED). In most of the cases, headache is benign and has a primary origin, with migraine as the most common diagnosis. Inappropriate use of ED for non-emergency conditions causes overcrowding, unnecessary testing, and increased medic...

journal_title：Expert review of neurotherapeutics

authors： Luciani M,Negro A,Spuntarelli V,Bentivegna E,Martelletti P

更新日期：2021-01-04 00:00:00

abstract：:Research has shown that structural variation in the human genome, including rare copy number variations (CNVs), contributes to genetic susceptibility to psychiatric diseases, such as schizophrenia, a devastating complex disorder with a high genetic load. The study by Vacic et al. applied a genome-wide approach to dete...

journal_title：Expert review of neurotherapeutics

authors： Nieratschker V,Meyer-Lindenberg A,Witt SH

更新日期：2011-07-01 00:00:00

abstract：:Advances in neuroscience have led to an expanded and improved understanding of neurobiological changes associated with rehabilitation and exercise in Parkinson's disease (PD). This knowledge has led to a direct clinical impact of increased referral for early and continuous exercise programs for individuals with PD (ph...

journal_title：Expert review of neurotherapeutics

authors： Sapir S,Ramig LO,Fox CM

更新日期：2011-06-01 00:00:00

abstract：:Generalized cognitive impairments are stable deficits linked to schizophrenia and key factors associated with functional disability in the disorder. Preclinical data suggest that second-generation antipsychotics could potentially reduce cognitive impairments; however, recent large clinical trials indicate only modest ...

journal_title：Expert review of neurotherapeutics

authors： Hill SK,Bishop JR,Palumbo D,Sweeney JA

更新日期：2010-01-01 00:00:00

abstract：:Translation of the analgesic efficacy of investigational neurotherapeutics from pre-clinical pain models into clinical trial phases is associated with a high risk of failure. Application of human pain biomarkers in early stages of clinical trials can potentially enhance the rate of successful translation, which would ...

journal_title：Expert review of neurotherapeutics

authors： Arendt-Nielsen L,Nielsen TA,Gazerani P

更新日期：2014-03-01 00:00:00

abstract：:Cognitive dysfunction (CD) affects 40-65% of multiple sclerosis (MS) patients and can have a great functional impact. It can be detected in all the disease phenotypes from the early stages of the disease and tends to progress over time. Memory, complex attention, information processing speed and executive functions ar...

journal_title：Expert review of neurotherapeutics

authors： Amato MP,Zipoli V,Portaccio E

更新日期：2008-10-01 00:00:00