Abstract:
:The NZB mouse is genetically predisposed to the development of autoimmune disease that resembles the human autoimmune systemic lupus erythematosus and autoimmune hemolytic anemia, with increased titers of anti-DNA, and Coombs' autoantibodies. The various autoimmune traits are controlled separately by a limited number of genes. Genetic studies have shown that several immune loci are involved in autoimmunity: T cell abnormalities, H-2 complex and immunoglobulin genes have been implicated. In this report, we present evidence for a significant correlation of NZB V kappa 1 haplotype defined by restriction fragment length polymorphism analysis with anti-erythrocyte autoantibodies in NZB x 129/J and NZB x SM/J recombinant inbred lines.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Bailey NC,Bona A,Dikman S,Bonilla F,Alt FW,Bona Cdoi
10.1002/eji.1830210415subject
Has Abstractpub_date
1991-04-01 00:00:00pages
959-65issue
4eissn
0014-2980issn
1521-4141journal_volume
21pub_type
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