Transcutaneous posterior tibial nerve stimulation for fecal incontinence in inflammatory bowel disease patients: a therapeutic option?

abstract：BACKGROUND:Assimilation of the preferred nutrient of enterocytes is mediated primarily by sodium (Na)-dependent cotransport (NGct) in the intestine. The predominant NGcT in villus cells, B0AT1, is inhibited secondary to a decrease in cotransporter numbers during chronic intestinal inflammation. In contrast, NGcT mediat...

journal_title：Inflammatory bowel diseases

authors： Arthur S,Saha P,Sundaram S,Kekuda R,Sundaram U

更新日期：2012-11-01 00:00:00

abstract：:Skin manifestations are common in patients suffering from inflammatory bowel disease (IBD) and can be associated with the disease itself, with nutritional deficiencies, or with therapy. All drugs currently used for treating IBD have the potential to cause dermatologic manifestations that can have a wide range of clini...

journal_title：Inflammatory bowel diseases

authors： Torres J,Buche S,Delaporte E,Colombel JF

更新日期：2013-04-01 00:00:00

abstract：:Restorative proctocolectomy with ileal-pouch anal anastomosis (RPC) is the operation of choice for ulcerative colitis (UC) patients requiring surgery. It is also used for patients with familial adenomatous polyposis (FAP). Pouchitis accounts for 10% of pouch failures. It is an idiopathic inflammatory condition that ma...

journal_title：Inflammatory bowel diseases

authors： Landy J,Al-Hassi HO,McLaughlin SD,Knight SC,Ciclitira PJ,Nicholls RJ,Clark SK,Hart AL

更新日期：2012-06-01 00:00:00

abstract：Background:Anastomotic recurrence is frequent in patients with Crohn's disease (CD) following ileocecal resection. The degree of endoscopic recurrence, quantified by the Rutgeerts score (RS), is correlated with the risk of clinical and surgical recurrence. Noninvasive modalities such as capsule endoscopy (CE), magnetic...

journal_title：Inflammatory bowel diseases

authors： Yung DE,Har-Noy O,Tham YS,Ben-Horin S,Eliakim R,Koulaouzidis A,Kopylov U

更新日期：2017-12-19 00:00:00

abstract：BACKGROUND:Substance use disorders (SUDs) impose a substantial individual and societal burden; however, the prevalence and associated factors in persons with inflammatory bowel disease (IBD) are largely unknown. We evaluated the prevalence and risk factors of SUD in an IBD cohort. METHODS:Inflammatory bowel disease pa...

journal_title：Inflammatory bowel diseases

authors： Carney H,Marrie RA,Bolton JM,Patten SB,Graff LA,Bernstein CN,Kowalec K

更新日期：2021-01-01 00:00:00

abstract：:: We evaluated retrospective smoking data reported by 221 patients with ulcerative colitis in 1984 and repeated in an identical questionnaire in 1989. Reported years of smoking initiation or smoking cessation agreed to a high extent; the difference between the two questionnaires was in mean (± SD) -0.1 ± 1.5 (median, ...

journal_title：Inflammatory bowel diseases

authors： Tysk C,Järnerot G

更新日期：1995-07-01 00:00:00

abstract：:Germ-free (GF) interleukin 10-deficient (IL-10) mice develop chronic colitis after colonization by normal enteric bacteria. Muc2 is the major structural component of the protective colonic mucus. Our aim was to determine whether primary or induced aberrations in Muc2 synthesis occur in GF IL-10 mice that develop colit...

journal_title：Inflammatory bowel diseases

authors： Schwerbrock NM,Makkink MK,van der Sluis M,Büller HA,Einerhand AW,Sartor RB,Dekker J

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Crohn's disease is a heterogeneous disease, and several classification systems have been developed to classify the patients in more homogeneous groups. Our aim was to assess the intra- and interobserver variation when classifying patients according to the widely used Vifenna classification. METHODS:Ten rand...

journal_title：Inflammatory bowel diseases

authors： Riis L,Munkholm P,Binder V,Skovgaard LT,Langholz E

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Mucosal expression of immunological mediators is modified in inflammatory bowel disease (IBD). Quantification of target gene messenger RNA (mRNA) transcripts depends on the normalization to a housekeeping or reference gene. Stability of housekeeping gene expression is critical for the accurate measurement of...

journal_title：Inflammatory bowel diseases

authors： Bamias G,Goukos D,Laoudi E,Balla IG,Siakavellas SI,Daikos GL,Ladas SD

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC) negatively affects health-related quality of life (HRQoL), but population-based and long-term data on this topic are scarce. Our aim was to determine the HRQoL in UC patients after a 10-year disease duration. METHODS:UC patients from a population-based inception cohort met at a presc...

journal_title：Inflammatory bowel diseases

authors： Hoivik ML,Moum B,Solberg IC,Cvancarova M,Hoie O,Vatn MH,Bernklev T,IBSEN Study Group.

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Granulocyte-macrophage colony-stimulating factor (GM-CSF) therapy is effective in treating some Crohn's disease (CD) patients and protects mice from colitis induced by dextran sulfate sodium (DSS) administration. However, its mechanisms of action remain elusive. We hypothesized that GM-CSF affects intestinal...

journal_title：Inflammatory bowel diseases

authors： Bernasconi E,Favre L,Maillard MH,Bachmann D,Pythoud C,Bouzourene H,Croze E,Velichko S,Parkinson J,Michetti P,Velin D

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease affects the quality of a patient's life in many ways, but no validated instrument for measuring disease-specific quality of life in these patients is available for use in Mainland China. The aim of our study was to develop and validate the Mainland Chinese translation of the Inflam...

journal_title：Inflammatory bowel diseases

authors： Ren WH,Lai M,Chen Y,Irvine EJ,Zhou YX

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Epithelial barrier disturbance is thought to contribute to the pathogenesis of inflammatory bowel diseases; however, it remains unclear whether it is a primary defect participating to the onset of inflammation or only a consequence of sustained inflammation. METHODS:A time course study of epithelial barrier...

journal_title：Inflammatory bowel diseases

authors： Suenaert P,Maerten P,Van Assche G,Van Driessche W,Geboes K,Bulteel V,Simaels J,Augustijns P,Ceuppens JL,Rutgeerts P,Perrier C

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel diseases (IBD) are believed to be driven by dysregulated interactions between the host and the gut microbiota. Our goal is to characterize and infer relationships between mucosal T cells, the host tissue environment, and microbial communities in patients with IBD who will serve as basis fo...

journal_title：Inflammatory bowel diseases

authors： Tang MS,Bowcutt R,Leung JM,Wolff MJ,Gundra UM,Hudesman D,Malter LB,Poles MA,Chen LA,Pei Z,Neto AG,Abidi WM,Ullman T,Mayer L,Bonneau RA,Cho I,Loke P

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Intestinal inflammation produces an induction of alkaline phosphatase (AP) activity that is attributable in part to augmented expression, accompanied by a change in isoform, in epithelial cells. METHODS:This study focuses on induction of AP in intestinal epithelial cells in vitro. RESULTS:Treatment with th...

journal_title：Inflammatory bowel diseases

authors： López-Posadas R,González R,Ballester I,Martínez-Moya P,Romero-Calvo I,Suárez MD,Zarzuelo A,Martínez-Augustin O,Sánchez de Medina F

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:A total of 254 senior consultant gastroenterologists with valid e-mail addresses were identified from the membership list of the British Society of Gastroenterology (BSG) 2007. METHODS:They were sent by e-mail a questionnaire which dealt with aspects of clinical practice and addressed cancer prevention in u...

journal_title：Inflammatory bowel diseases

authors： Mayberry H,Moshkovska T,Mayberry JF

更新日期：2009-02-01 00:00:00

abstract：:The principal investigator is responsible for everything involved in the conduct of a clinical research study. Prior to the initiation of any clinical trial, an investigator must become acquainted with the material requirements, personnel needs, and best practices involved in the conduct of the trial. Commitment to a ...

journal_title：Inflammatory bowel diseases

authors： Wolf DC,Katz S,Safdi MA,Sandler RS,Lewis JD

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) patients are at increased risk of venous thromboembolism (VTE), which is most pronounced during a disease flare. We explored the cost-effectiveness of pharmacological VTE prophylaxis in an outpatient setting. METHODS:Markov decision analysis was conducted from a societal per...

journal_title：Inflammatory bowel diseases

authors： Nguyen GC,Sharma S

更新日期：2013-09-01 00:00:00

abstract：:Ulcerative colitis (UC) and Crohn's disease (CD) may directly result in morbidity and rarely mortality from complications such as colorectal cancer or sepsis. Mortality rates compared with the matched general population, measured by standardized mortality ratio, may therefore be increased. This review examines the evi...

journal_title：Inflammatory bowel diseases

authors： Selinger CP,Leong RW

更新日期：2012-08-01 00:00:00

abstract：:Lymphocyte migration is at the heart of chronic inflammatory ailments, including inflammatory bowel disease (IBD). Whereas naïve lymphocytes migrate to all secondary lymphoid organs, they are mostly excluded from nonlymphoid peripheral tissues. Upon activation, lymphocytes change their pattern of adhesion receptors an...

journal_title：Inflammatory bowel diseases

authors： Mora JR

更新日期：2008-02-01 00:00:00

abstract：:Inflammatory bowel diseases (IBDs) are highly heterogeneous in disease phenotype, behavior, and response to therapy. Diagnostic and therapeutic decisions in IBD are based primarily on clinical and endoscopic severity and histopathologic analysis of intestinal biopsies. With this approach, however, only a minority of p...

journal_title：Inflammatory bowel diseases

authors： Haberman Y

更新日期：2020-09-18 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) patients have a high incidence of wound and overall postoperative complications. A totally laparoscopic approach could potentially reduce these risks. We adopted totally laparoscopic total proctocolectomy (TL-TPC) using the perineal wound for extraction as the procedure of ch...

journal_title：Inflammatory bowel diseases

authors： Holder-Murray J,Zoccali M,Hurst RD,Umanskiy K,Rubin M,Fichera A

更新日期：2012-05-01 00:00:00

abstract：Background:Patients requiring optimization of therapy for suboptimal response and/or targeting more robust outcomes may eventually reach high serum levels. Data evaluating the relationship between infliximab concentration and toxicity are limited. The aim of this study was to evaluate the frequency of adverse events (A...

journal_title：Inflammatory bowel diseases

authors： Greener T,Kabakchiev B,Steinhart AH,Silverberg MS

更新日期：2018-07-12 00:00:00

abstract：:Biologic treatments have revolutionized the way we treat inflammatory bowel disease patients (IBD). Anti-tumor necrosis factor (anti-TNF) antibodies are superior to conventional therapies to achieve sustained remission without steroids and mucosal healing. The objective of IBD treatment has evolved from symptom allevi...

journal_title：Inflammatory bowel diseases

authors： Louis E

更新日期：2018-03-19 00:00:00

abstract：:Inflammatory bowel diseases (IBD) include ulcerative colitis and Crohn's disease. The immune response in ulcerative colitis is different from the Crohn's disease. Accumulating evidence suggests that IBD results from an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host. Severa...

journal_title：Inflammatory bowel diseases

authors： Fonseca-Camarillo G,Yamamoto-Furusho JK

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Clinical observations or animal studies implicate enteric glial cells in motility disorders, irritable bowel syndrome, inflammatory bowel disease, gastrointestinal (GI) infections, postoperative ileus, and slow transit constipation. Mechanisms underlying glial responses to inflammation in human GI tract are ...

journal_title：Inflammatory bowel diseases

authors： Liñán-Rico A,Turco F,Ochoa-Cortes F,Harzman A,Needleman BJ,Arsenescu R,Abdel-Rasoul M,Fadda P,Grants I,Whitaker E,Cuomo R,Christofi FL

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:FTY720 is a novel reagent that possesses potent immunosuppressive activity. The immunosuppression induced by FTY720 is mediated by completely different mechanisms from those of conventional immunosuppressants, that is, by altering the tissue distribution of lymphocytes rather than inhibiting activation. In t...

journal_title：Inflammatory bowel diseases

authors： Mizushima T,Ito T,Kishi D,Kai Y,Tamagawa H,Nezu R,Kiyono H,Matsuda H

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Many chronic illnesses are accompanied by impaired cognitive functioning. In people with Inflammatory Bowel Disease (IBD), there is some research to suggest a decrement in verbal IQ (VIQ), when compared to people with Irritable Bowel Syndrome (IBS) and healthy controls. Although this is an important finding,...

journal_title：Inflammatory bowel diseases

authors： Dancey CP,Attree EA,Stuart G,Wilson C,Sonnet A

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:According to the Montreal Classification, upper gastrointestinal tract phenotype L4 is uncommon in Caucasian patients with Crohn's disease (CD) but carries excess risk of recurrence. We studied the clinical course of CD in Chinese patients presenting with the L4 phenotype and factors predicting its occurrenc...

journal_title：Inflammatory bowel diseases

authors： Chow DK,Sung JJ,Wu JC,Tsoi KK,Leong RW,Chan FK

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Though vedolizumab has received regulatory approval for the treatment of Crohn's disease (CD) and ulcerative colitis (UC) in adults, there is increasing off-label use in children. AIMS:To describe the experience with vedolizumab in pediatric inflammatory bowel disease (IBD) patients at 3 tertiary IBD center...

journal_title：Inflammatory bowel diseases

authors： Singh N,Rabizadeh S,Jossen J,Pittman N,Check M,Hashemi G,Phan BL,Hyams JS,Dubinsky MC

更新日期：2016-09-01 00:00:00