Effects of estradiol on the stimulation of dopamine turnover in mesolimbic and nigrostriatal systems by cocaine- and amphetamine-regulated transcript peptide in female rats.

abstract：:Tenascin-C is an extracellular matrix glycoprotein involved in cell adhesion and migration, and neurite outgrowth. Since these processes have been found to be under thyroid control in the developing rat brain, we have investigated the effect of congenital hypothyroidism on tenascin-C expression. At birth, in situ hybr...

journal_title：Neuroscience

authors： Alvarez-Dolado M,González-Sancho JM,Bernal J,Muñoz A

更新日期：1998-05-01 00:00:00

abstract：:Using indirect immunofluorescence technique combined with retrograde tracing as well as surgical lesions, a system of spinothalamic neurons containing both galanin- and cholecystokinin-like immunoreactivity has been defined. The cell bodies are located in the lumbar segments L1-L5 with a preferential localization dors...

journal_title：Neuroscience

authors： Ju G,Melander T,Ceccatelli S,Hökfelt T,Frey P

更新日期：1987-02-01 00:00:00

abstract：:Recent studies using DNA fragmentation assays suggest a role for apoptosis in cell death in Huntington's disease. In this study, we investigated the relationship between the degree of DNA fragmentation and the number of trinucleotide (CAG) repeats of the Huntington's disease gene in striatal tissue from Huntington's d...

journal_title：Neuroscience

authors： Butterworth NJ,Williams L,Bullock JY,Love DR,Faull RL,Dragunow M

更新日期：1998-11-01 00:00:00

abstract：:The distribution of the urea cycle enzyme, argininosuccinate synthetase, in the rat brain was determined using immunohistochemistry. This enzyme participates in the only known metabolic pathway for citrulline, its condensation with aspartate to form argininosuccinate, which can then be cleaved to fumarate and arginine...

journal_title：Neuroscience

authors： Arnt-Ramos LR,O'Brien WE,Vincent SR

更新日期：1992-12-01 00:00:00

abstract：:We have reported that hypoxia affects the hypothalamic-pituitary-adrenal (HPA) axis and behavior by driving the expression of central corticotropin-releasing hormone (CRH) and its receptors in adult mammals, and this effect is modulated by other factors. Here, we address whether or not intermittent hypoxia (IH) or res...

journal_title：Neuroscience

authors： Fan JM,Chen XQ,Jin H,Du JZ

更新日期：2009-04-10 00:00:00

abstract：:Hippocampal neurogenesis in adult mammals is influenced by many factors. Lesioning of the entorhinal cortex is a standard model used to study injury and repair in the hippocampus. Here we use bromodeoxyuridine (BrdU) labeling combined with immunohistochemical identification using cell type specific markers to follow t...

journal_title：Neuroscience

authors： Gama Sosa MA,Wen PH,De Gasperi R,Perez GM,Senturk E,Friedrich VL Jr,Elder GA

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Women are more prone to major depressive disorders (MDDs) and the incidence of MDD in women is almost twice that of men. Insular cortex abnormalities are a common finding in neuroanatomical studies of patients with MDD. However, it remains largely unclear whether female MDD patients at different clinical stag...

journal_title：Neuroscience

authors： Liu CH,Jing B,Ma X,Xu PF,Zhang Y,Li F,Wang YP,Tang LR,Wang YJ,Li HY,Wang CY

更新日期：2014-03-14 00:00:00

abstract：:Inflammation is crucially involved in many diseases of the CNS. Immune cells may attack the CNS, as in multiple sclerosis, and therefore be responsible for primary damage. Immune cells may also be activated by injury to the CNS, as for example in stroke or brain trauma, secondarily enhancing lesion growth. In general,...

journal_title：Neuroscience

authors： Wunder A,Klohs J,Dirnagl U

更新日期：2009-02-06 00:00:00

abstract：:Two types of GABAergic interneurone are known to express cholecystokinin-related peptides in the isocortex: basket cells, which preferentially innervate the somata and proximal dendrites of pyramidal cells; and double bouquet cells, which innervate distal dendrites and dendritic spines. In the hippocampus, cholecystok...

journal_title：Neuroscience

authors： Cope DW,Maccaferri G,Márton LF,Roberts JD,Cobden PM,Somogyi P

更新日期：2002-01-01 00:00:00

abstract：:We have recently reported on the efficacy of an NK1 tachykinin receptor antagonist in improving outcome following stroke, including reduced blood-brain barrier (BBB) disruption, reduced cerebral edema and improved functional outcome. The clinically approved stroke treatment, tissue plasminogen activator (tPA), has bee...

journal_title：Neuroscience

authors： Turner RJ,Vink R

更新日期：2012-09-18 00:00:00

abstract：:Physiological evidence has indicated that serotonin (5-hydroxytryptamine) could be a regulator of cerebral blood flow in various regions of the brain. In the present study, tryptophan hydroxylase immunocytochemistry was used to characterize, both at the light and electron microscopic levels, serotonergic nerve termina...

journal_title：Neuroscience

authors： Cohen Z,Ehret M,Maitre M,Hamel E

更新日期：1995-06-01 00:00:00

abstract：:Parkinson's disease (PD) is a motor disorder that involves death of dopaminergic neurons in the substantia nigra pars compacta. Parkin is an autosomal recessive gene that is mutated in early onset PD. We investigated the role of parkin and autophagic clearance in postmortem nigrostriatal tissues from 22 non-familial s...

journal_title：Neuroscience

authors： Lonskaya I,Hebron ML,Algarzae NK,Desforges N,Moussa CE

更新日期：2013-03-01 00:00:00

abstract：:In the present study we have investigated the possible role of gap junctions in the induction and manifestation of 4-aminopyridine-induced acute seizure activity both at the primary focus and at the mirror focus in anaesthetized rats by combining electrophysiological, pharmacological and molecular biological technique...

journal_title：Neuroscience

authors： Szente M,Gajda Z,Said Ali K,Hermesz E

更新日期：2002-01-01 00:00:00

abstract：:The effects of electrical stimulation of the hypothalamus paraventricular nucleus on the spontaneous firing of mitral and granule cells in the main olfactory bulb were examined in ovariectomized female rats under urethane anaesthesia. High-frequency stimulation (0.5-1.0 mA, 10-20 pulses at 100 Hz) of the paraventricul...

journal_title：Neuroscience

authors： Yu GZ,Kaba H,Okutani F,Takahashi S,Higuchi T,Seto K

更新日期：1996-06-01 00:00:00

abstract：:In adult females many of the effects of the neuropeptide oxytocin are steroid, and especially estrogen dependent. Here we demonstrate for the first time that neonatal manipulation of oxytocin can affect the expression of estrogen receptor alpha. On the first day of postnatal life male and female prairie voles (Microtu...

journal_title：Neuroscience

authors： Yamamoto Y,Carter CS,Cushing BS

更新日期：2006-01-01 00:00:00

abstract：:The presence of mRNAs in synaptic terminals and their regulated translation are important factors in neuronal communication and plasticity. Heterogeneous nuclear ribonucleoprotein (hnRNP) complexes are involved in the translocation, stability, and subcellular localization of mRNA and the regulation of its translation....

journal_title：Neuroscience

authors： Lico DT,Lopes GS,Brusco J,Rosa JC,Gould RM,De Giorgis JA,Larson RE

更新日期：2015-08-06 00:00:00

abstract：:3-Nitropropionic acid (3-NP), an irreversible inhibitor of succinate dehydrogenase, induced ATP depletion and both necrosis and apoptosis in human NT2-N neurons. Necrosis occurred predominantly within the first two days, and increased in a dose-dependent fashion with the concentration of 3-NP, whereas apoptosis was ob...

journal_title：Neuroscience

authors： Lee WT,Itoh T,Pleasure D

更新日期：2002-01-01 00:00:00

abstract：:The area postrema has been implicated as a major station for the processing of visceral sensory information, involved primarily in eliciting rapid homeostatic responses to fluid and nutrient imbalances. Yet the precise relationship of efferent projections from the area postrema to medullary motor and relay nuclei invo...

journal_title：Neuroscience

authors： Cunningham ET Jr,Miselis RR,Sawchenko PE

更新日期：1994-02-01 00:00:00

abstract：:The main projection neurones of the dorsal cochlear nucleus, termed pyramidal, bipolar or fusiform cells, have an apical dendritic arbor approaching the ependymal surface of the nucleus and a basal arbor oppositely directed. In Golgi-Del Rio-Hortega material these neurones were studied, with the light microscope, in n...

journal_title：Neuroscience

authors： Blackstad TW,Osen KK,Mugnaini E

更新日期：1984-11-01 00:00:00

abstract：:Cerebral ischemia is the most common cause of stroke with high morbidity, disability and mortality. Sirtuin-2 (Sirt2), a vitally important NAD+-dependent deacetylase which has been widely researched in central nervous system diseases, has also been identified as a promising treatment target using its specific inhibito...

journal_title：Neuroscience

authors： Wu D,Lu W,Wei Z,Xu M,Liu X

更新日期：2018-03-15 00:00:00

abstract：:Reg-2 is a secreted protein that is expressed de novo in motoneurons, sympathetic neurons, and dorsal root ganglion (DRG) neurons after nerve injury and which can act as a Schwann cell mitogen. We now show that Reg-2 is also upregulated by DRG neurons in inflammation with a very unusual expression pattern. In a rat mo...

journal_title：Neuroscience

authors： Averill S,Inglis JJ,King VR,Thompson SW,Cafferty WB,Shortland PJ,Hunt SP,Kidd BL,Priestley JV

更新日期：2008-09-09 00:00:00

abstract：:The postnatal development of GABAB binding sites in rat brain was studied by quantitative receptor autoradiography using [3H]GABA under selective conditions. Binding levels peak at regionally specific times during the first three weeks of life and then decline to adult levels. GABAB binding peaked in the globus pallid...

journal_title：Neuroscience

authors： Turgeon SM,Albin RL

更新日期：1994-09-01 00:00:00

abstract：:Experiments in a variety of preparations have indicated that excessive activation of receptors for the excitatory amino acids glutamate and aspartate may mediate irreversible anoxic neuronal injury. We investigated this hypothesis in the in vitro hippocampal slice. Rat hippocampal slices perfused for 40 min with buffe...

journal_title：Neuroscience

authors： Clark GD,Rothman SM

更新日期：1987-06-01 00:00:00

abstract：:Locomotion involves complex combinations of translational and rotational head movements. For gaze stability, this necessitates the interplay of angular and linear vestibulo-ocular reflexes (VOR) as well as the integration of visual feedback about the desired viewing distance. Furthermore, gaze stabilizing systems must...

journal_title：Neuroscience

authors： Dietrich H,Wuehr M

更新日期：2019-06-01 00:00:00

abstract：:Treatment of P19 embryonal carcinoma cells with retinoic acid induces their differentiation into a population of cells consisting of neurons and other cell types normally derived from neuroectoderm. We used immunohistological and histochemical techniques to identify some of the neurotransmitters in the P19-derived neu...

journal_title：Neuroscience

authors： Staines WA,Morassutti DJ,Reuhl KR,Ally AI,McBurney MW

更新日期：1994-02-01 00:00:00

abstract：:Migraine attacks are typically described as unilateral, throbbing pain that is usually accompanied by nausea, vomiting, and exaggerated sensitivities to light, noise and smell. The headache phase of a migraine attack is mediated by activation of the trigeminovascular pathway; a nociceptive pathway that originates in t...

journal_title：Neuroscience

authors： Kagan R,Kainz V,Burstein R,Noseda R

更新日期：2013-09-17 00:00:00

abstract：:The function of N-methyl-d-aspartate (NMDA) receptors in primary afferents remains controversial, in particular regarding their ability to evoke substance P release in the spinal cord. The objective of this study was, first, to confirm that substance P release evoked by NMDA is mediated by NMDA receptors in primary af...

journal_title：Neuroscience

authors： Chen W,Zhang G,Marvizón JC

更新日期：2010-03-31 00:00:00

abstract：:The neuronal uptake and laminar distribution of cortically injected tritium-labeled gamma-aminobutyrate (GABA), aspartic acid, glutamate and glycine was examined in the prestriate cortex of squirrel monkeys. The intent of this investigation was not to examine the role of these amino acids as neurotransmitters, but to ...

journal_title：Neuroscience

authors： Carroll EW,Wong-Riley M

更新日期：1987-08-01 00:00:00

abstract：:Substance P and calcitonin gene-related peptide (CGRP) are present in nerve fibers innervating the submandibular gland. Radiotherapy of tumors in the head and neck region usually embraces the salivary glands in the irradiated field and consequently a dramatic decrease in salivary function is seen. In this study, the s...

journal_title：Neuroscience

authors： Forsgren S,Franzén L,Funegård U,Gustafsson H,Henriksson R

更新日期：1992-01-01 00:00:00

abstract：:p53 and parkin are involved in mitochondrial quality control. The present study aimed to characterize the functional significance of parkin/p53 in the development of mitochondrial dysfunction and the pathophysiology of neuropathic pain in type I diabetes. Type I diabetes was induced in mice (N = 170) using streptozoto...

journal_title：Neuroscience

authors： Yamashita A,Matsuoka Y,Matsuda M,Kawai K,Sawa T,Amaya F

更新日期：2019-09-15 00:00:00